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  Masrudin Md Yusoff,Muggundha Raoov,Noorfatimah Yahaya,Noorashikin Md Salleh RSC Adv., 2017,7, 35832-35844
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Trifluoromethylbenzenes

2,4-Bis-(trifluoromethyl)fluorobenzene: A Comprehensive Overview

2,4-Bis-(trifluoromethyl)fluorobenzene (CAS No. 36649-94-2) is a versatile organic compound with significant applications in the fields of chemistry, biology, and pharmaceuticals. This compound is characterized by its unique molecular structure, which includes two trifluoromethyl groups and a fluorine atom attached to a benzene ring. The presence of these functional groups imparts specific chemical and physical properties that make it a valuable intermediate in various synthetic processes.

The chemical formula of 2,4-Bis-(trifluoromethyl)fluorobenzene is C₉H₅F₃, and its molecular weight is 188.13 g/mol. The compound is a colorless liquid at room temperature with a boiling point of approximately 150°C. Its solubility in water is low, but it is highly soluble in organic solvents such as dichloromethane, acetone, and ethyl acetate. These properties make it suitable for use in a wide range of chemical reactions and processes.

In the realm of synthetic chemistry, 2,4-Bis-(trifluoromethyl)fluorobenzene serves as a key building block for the synthesis of various pharmaceuticals and agrochemicals. The trifluoromethyl groups are known to enhance the metabolic stability and lipophilicity of molecules, which are crucial factors in drug design. Recent studies have shown that compounds derived from 2,4-Bis-(trifluoromethyl)fluorobenzene exhibit promising biological activities, including anti-inflammatory, antiviral, and anticancer properties.

A notable example of its application in drug development is the synthesis of novel antiviral agents. Researchers have utilized 2,4-Bis-(trifluoromethyl)fluorobenzene as a starting material to develop compounds that target viral replication mechanisms. These compounds have shown efficacy against a variety of viruses, including influenza and hepatitis C virus (HCV). The trifluoromethyl groups contribute to the high binding affinity and selectivity of these antiviral agents, making them potential candidates for further clinical evaluation.

In addition to its role in pharmaceuticals, 2,4-Bis-(trifluoromethyl)fluorobenzene has found applications in the development of agrochemicals. The compound's unique structure allows it to be used as an intermediate in the synthesis of herbicides and fungicides with improved efficacy and reduced environmental impact. For instance, studies have demonstrated that derivatives of 2,4-Bis-(trifluoromethyl)fluorobenzene can effectively control weeds and fungal pathogens while minimizing toxicity to non-target organisms.

The environmental fate and safety profile of 2,4-Bis-(trifluoromethyl)fluorobenzene are also important considerations. Research has shown that the compound degrades slowly in the environment but does not bioaccumulate significantly in aquatic organisms. This characteristic makes it a relatively safe choice for industrial applications compared to other halogenated compounds. However, proper handling and disposal practices should always be followed to minimize any potential risks.

In conclusion, 2,4-Bis-(trifluoromethyl)fluorobenzene (CAS No. 36649-94-2) is a valuable compound with diverse applications in chemistry, biology, and pharmaceuticals. Its unique molecular structure provides a foundation for the development of novel drugs and agrochemicals with enhanced properties. Ongoing research continues to uncover new possibilities for this versatile compound, further solidifying its importance in modern scientific advancements.

• 64248-61-9(2,4-Difluorobenzotrifluoride)
• 158364-83-1(2-Fluoro-4-methylbenzotrifluoride)
• 62927-56-4(Benzene, fluoro(trifluoromethyl)-)
• 122030-04-0(2,4,6-Trifluorobenzotrifluoride)
• 793-92-0(perfluoro(1,3,5-trimethylbenzene))
• 1214331-63-1(2-Fluoro-1-methyl-3-(trifluoromethyl)benzene)
• 392-85-8(1-Fluoro-2-trifluoromethylbenzene)
• 887268-09-9(2,6-Bis(trifluoromethyl)fluorobenzene)
• 64248-60-8(2,6-Difluorobenzotrifluoride)
• 393-38-4(2,5-Difluorobenzotrifluoride)