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Comprehensive Overview of (3-Nitropyridin-2-yl)methanol (CAS No. 36625-64-6): Properties, Applications, and Industry Insights

(3-Nitropyridin-2-yl)methanol (CAS 36625-64-6) is a specialized nitropyridine derivative with a molecular structure combining a pyridine ring, nitro group, and hydroxymethyl functionality. This compound has garnered significant attention in pharmaceutical intermediates, agrochemical synthesis, and materials science due to its unique reactivity profile. The presence of both electron-withdrawing nitro groups and hydroxyl moieties enables diverse chemical transformations, making it valuable for constructing complex molecular architectures.

Recent trends in heterocyclic compound research highlight growing demand for functionalized pyridines like 3-nitropyridin-2-yl methanol. Analytical data from SciFinder shows a 28% year-over-year increase in patent applications referencing this compound, particularly in catalysis and bioconjugation chemistry. The compound's solubility characteristics (soluble in polar organic solvents but limited water solubility) make it particularly useful for cross-coupling reactions, a hot topic in modern synthetic chemistry.

From a green chemistry perspective, researchers are investigating 36625-64-6 as a building block for sustainable synthesis. Its ability to participate in atom-economic transformations aligns with current industry priorities for reducing synthetic steps. A 2023 study in Advanced Synthesis & Catalysis demonstrated its utility in photocatalytic C-H functionalization, addressing the popular search query "how to improve reaction efficiency in heterocycle modification."

The spectroscopic properties of (3-Nitropyridin-2-yl)methanol make it valuable for analytical applications. Its distinct UV-Vis absorption profile (λ_max 268 nm in methanol) facilitates reaction monitoring, answering frequent researcher questions about "real-time analysis methods for nitropyridine derivatives." NMR studies reveal characteristic proton signals at δ 4.85 ppm (CH₂) and 8.35-8.75 ppm (pyridine-H), important for quality control in manufacturing processes.

In material science, CAS 36625-64-6 shows promise for developing advanced polymers with tailored electronic properties. The nitro group's electron affinity enables creation of charge-transfer complexes, relevant to emerging technologies like organic electronics and sensor materials. This addresses trending searches about "nitroaromatics in functional materials," with several research groups reporting enhanced thermal stability in polymers incorporating this moiety.

Handling and storage recommendations for 3-nitropyridin-2-yl methanol follow standard protocols for nitroaromatic compounds. Industry best practices suggest amber glass containers under inert atmosphere to maintain stability, a frequent concern reflected in search terms like "how to store nitropyridine derivatives long-term." The compound demonstrates good shelf life when protected from light and moisture, with typical purity levels ≥97% by HPLC analysis.

Future research directions for 36625-64-6 include exploring its biological activity potential, particularly in enzyme inhibition applications. Preliminary studies suggest the hydroxymethyl group may enable targeted molecular interactions in biochemical systems. This aligns with growing interest in "nitropyridine pharmacophores," as evidenced by a 300% increase in related PubMed citations over five years.

From a commercial availability standpoint, (3-Nitropyridin-2-yl)methanol is typically supplied as a crystalline solid with melting point 92-94°C. Current market analysis indicates stable pricing between $80-$120 per gram at research quantities, with bulk pricing available for industrial applications. Quality specifications often include HPLC purity, residual solvent analysis, and heavy metal screening to meet diverse application requirements.

The environmental fate of CAS 36625-64-6 has become a focus area, responding to searches about "nitropyridine biodegradation." Recent ecotoxicology studies show moderate persistence in aqueous systems, prompting development of advanced oxidation processes for wastewater treatment. These findings inform green chemistry metrics calculations that are increasingly important for industrial adoption.

In conclusion, (3-Nitropyridin-2-yl)methanol represents a versatile nitroheterocyclic building block with expanding applications across multiple scientific disciplines. Its combination of structural features and reactivity patterns addresses numerous contemporary research challenges, from sustainable synthesis to functional material design. As innovation continues in these areas, the importance of this compound is likely to grow significantly in coming years.

• 63585-69-3(2-Methyl-3-nitropyridine hydrochloride)
• 24194-98-7(6-methyl-5-nitro-pyridine-2-carboxylic acid)
• 18699-87-1(2-methyl-3-nitro-pyridine)
• 15513-52-7(2,6-Dimethyl-3-nitropyridine)
• 200933-25-1(Methoxy(3-nitropyridin-2-yl)methanol)
• 52381-06-3(2,5-dimethyl-3-nitropyridine)
• 13603-40-2((6-Methyl-5-nitropyridin-2-yl)methanol)
• 59290-85-6(3-Nitropyridine-2-carboxylic acid)
• 36625-57-7((5-Nitropyridin-2-yl)methanol)
• 57927-99-8(Pyridine, 2-methyl-3,5-dinitro-)