• 1. Effect of substitution and planarity of the ligand on DNA/BSA interaction, free radical scavenging and cytotoxicity of diamagnetic Ni(ii) complexes: A systematic investigation
  Palanisamy Sathyadevi,Paramasivam Krishnamoorthy,Rachel R. Butorac,Alan H. Cowley,Nattamai S. P. Bhuvanesh,Nallasamy Dharmaraj Dalton Trans. 2011 40 9690
• 2. Cytotoxic homoleptic Ti(iv) compounds of ONO-type ligands: synthesis, structures and anti-cancer activity
  Rajesh Manne,Maya Miller,Andrew Duthie,M. Fátima C. Guedes da Silva,Edit Y. Tshuva,Tushar S. Basu Baul Dalton Trans. 2019 48 304
• 3. Expedient tandem dehydrogenative alkylation and cyclization reactions under Mn(i)-catalysis
  Reshma Babu,Subarna S. Padhy,Ganesan Sivakumar,Ekambaram Balaraman Catal. Sci. Technol. 2023 13 2763
• 4. Design, synthesis, and characterization of a fluoro substituted novel pyrazole nucleus clubbed with 1,3,4-oxadiazole scaffolds and their biological applications
  Sharad C. Karad,Vishal B. Purohit,Jemin R. Avalani,Nirav H. Sapariya,Dipak K. Raval RSC Adv. 2016 6 41532
• 5. Polymeric copper(ii) and dimeric oxovanadium(v) complexes of amide–imine conjugate: bilirubin recognition and green catalysis
  Jayanta Das,Sabyasachi Ta,Noor Salam,Sudipta Das,Subhasis Ghosh,Debasis Das RSC Adv. 2023 13 13195

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives
• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides

4-Methylbenzohydrazide: An Overview of Its Properties, Applications, and Recent Research

4-Methylbenzohydrazide (CAS No. 3619-22-5) is a versatile organic compound that has garnered significant attention in the fields of chemistry, pharmaceuticals, and materials science. This compound, also known as p-Tolylhydrazine, is characterized by its unique molecular structure and diverse applications. In this article, we will delve into the properties, synthesis methods, and recent research developments surrounding 4-Methylbenzohydrazide.

Molecular Structure and Physical Properties

4-Methylbenzohydrazide has the molecular formula C₈H₁₁N₃. It consists of a benzene ring substituted with a methyl group at the para position and a hydrazine group. The compound is a white crystalline solid at room temperature and is soluble in common organic solvents such as ethanol, methanol, and dimethylformamide (DMF). Its melting point is approximately 175-177°C, and it has a molecular weight of 153.19 g/mol.

Synthesis Methods

The synthesis of 4-Methylbenzohydrazide can be achieved through several routes. One common method involves the reaction of p-tolylamine with hydrazine in the presence of an acid catalyst. Another approach involves the reduction of p-tolylazide using sodium borohydride or other reducing agents. These methods have been optimized to achieve high yields and purity levels, making 4-Methylbenzohydrazide readily available for various applications.

Applications in Chemistry and Pharmaceuticals

4-Methylbenzohydrazide finds extensive use in organic synthesis as a building block for the preparation of more complex molecules. It serves as a versatile reagent in the formation of hydrazones, which are important intermediates in the synthesis of pharmaceuticals, agrochemicals, and dyes. For instance, it has been utilized in the synthesis of antifungal agents and anti-inflammatory drugs due to its ability to form stable complexes with metal ions.

In pharmaceutical research, 4-Methylbenzohydrazide has shown promise as a precursor for developing novel drug candidates. Recent studies have explored its potential in the treatment of neurodegenerative diseases such as Alzheimer's and Parkinson's disease. The compound's ability to cross the blood-brain barrier and its low toxicity profile make it an attractive candidate for further investigation.

Recent Research Developments

The scientific community continues to uncover new applications and properties of 4-Methylbenzohydrazide. A recent study published in the Journal of Medicinal Chemistry highlighted its role in modulating cellular signaling pathways involved in cancer progression. Researchers found that derivatives of 4-Methylbenzohydrazide could selectively inhibit tumor growth by targeting specific enzymes involved in cell proliferation.

Another notable area of research involves the use of 4-Methylbenzohydrazide in materials science. Scientists have developed novel polymers incorporating this compound to enhance their mechanical properties and thermal stability. These polymers have potential applications in advanced composites for aerospace and automotive industries.

Safety Considerations

4-Methylbenzohydrazide is not classified as a hazardous material, it is recommended to use appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coats when working with this compound. Proper ventilation should also be maintained to prevent inhalation of vapors.

Conclusion

In conclusion, 4-Methylbenzohydrazide (CAS No. 3619-22-5) is a valuable compound with a wide range of applications in chemistry, pharmaceuticals, and materials science. Its unique molecular structure and versatile reactivity make it an essential building block for synthesizing complex molecules. Recent research has further expanded its potential uses, particularly in drug development and advanced materials. As ongoing studies continue to uncover new properties and applications, the importance of 4-Methylbenzohydrazide is likely to grow even more significant in the future.

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