• 1. Knock-on synthesis of tritopic calix[4]pyrrole host for enhanced anion interactions
  Mandeep K. Chahal,Jan Labuta,Václav B?ezina,Paul A. Karr,Yoshitaka Matsushita,Whitney A. Webre,Daniel T. Payne,Katsuhiko Ariga,Francis D'Souza,Jonathan P. Hill Dalton Trans. 2019 48 15583

• Solvents and Organic Chemicals Organic Compounds Heterocyclic Compounds
• Solvents and Organic Chemicals Organic Compounds cyanides/Cyanides

5,6-Diaminopyrazine-2,3-dicarbonitrile (CAS No. 36023-58-2): A Comprehensive Overview

5,6-Diaminopyrazine-2,3-dicarbonitrile (CAS No. 36023-58-2) is a versatile organic compound that has garnered significant attention in the fields of medicinal chemistry and materials science. This compound, also known as DAPDC, is characterized by its unique molecular structure and diverse chemical properties, making it a valuable component in various research and industrial applications.

The molecular formula of 5,6-Diaminopyrazine-2,3-dicarbonitrile is C₆H₄N₆, and its molecular weight is approximately 152.12 g/mol. The compound features a pyrazine core with two amino groups and two cyano groups, which contribute to its reactivity and potential for functionalization. The presence of these functional groups allows for a wide range of chemical transformations and interactions, making DAPDC a promising candidate for the development of new materials and pharmaceuticals.

In recent years, the study of 5,6-Diaminopyrazine-2,3-dicarbonitrile has been driven by its potential applications in the development of novel drugs. Research has shown that compounds derived from DAPDC exhibit promising biological activities, including antitumor, anti-inflammatory, and antimicrobial properties. For instance, a study published in the Journal of Medicinal Chemistry reported that derivatives of DAPDC demonstrated significant cytotoxic activity against various cancer cell lines, suggesting their potential as lead compounds for anticancer drug development.

Beyond its pharmaceutical applications, 5,6-Diaminopyrazine-2,3-dicarbonitrile has also been explored for its use in materials science. The compound's ability to form stable complexes with metal ions makes it a valuable ligand in the synthesis of coordination polymers and metal-organic frameworks (MOFs). These materials have found applications in gas storage, catalysis, and sensing technologies. A recent study in the Journal of Materials Chemistry A highlighted the use of DAPDC-based MOFs for efficient carbon dioxide capture and separation, demonstrating their potential in addressing environmental challenges.

The synthesis of 5,6-Diaminopyrazine-2,3-dicarbonitrile typically involves a multi-step process that includes the condensation of appropriate precursors followed by functional group modifications. One common synthetic route involves the reaction of 1H-pyrazine-2,3-dicarbonitrile with ammonia or an equivalent amine source under controlled conditions. The optimization of these synthetic methods has been a focus of recent research efforts to improve yield and purity while minimizing environmental impact.

The physical properties of 5,6-Diaminopyrazine-2,3-dicarbonitrile, such as its melting point (approximately 180°C) and solubility in polar solvents like dimethyl sulfoxide (DMSO) and dimethylformamide (DMF), make it suitable for various analytical techniques. These properties are crucial for characterizing the compound and monitoring its behavior in different environments. Techniques such as nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS) are commonly employed to confirm the structure and purity of DAPDC.

In addition to its chemical properties, the safety profile of 5,6-Diaminopyrazine-2,3-dicarbonitrile is an important consideration for both researchers and industrial users. While the compound is generally considered safe when handled properly, it is essential to follow standard laboratory safety protocols to minimize any potential risks. This includes wearing appropriate personal protective equipment (PPE) such as gloves and goggles, working in well-ventilated areas or fume hoods, and disposing of waste materials according to local regulations.

The future prospects for 5,6-Diaminopyrazine-2,3-dicarbonitrile are promising across multiple fields. In medicinal chemistry, ongoing research aims to identify more potent derivatives with improved pharmacological profiles. In materials science, the development of advanced MOFs based on DAPDC

In conclusion, 5,6-Diaminopyrazine-2,3-dicarbonitrile (CAS No. 36023-58-2)DAPDC

• 123188-99-8(2,3-Pyrazinedicarbonitrile,5-amino-6-(ethylamino)-)
• 75063-64-8(2,3-Pyrazinedicarbonitrile, 5-amino-6-methyl-)
• 58091-66-0(Pyrazinecarbonitrile, 3-amino-5-methyl-)
• 150960-06-8(2,3-Pyrazinedicarbonitrile,5,6-bis(methylamino)-)
• 53114-83-3(5,6-dimethylpyrazine-2,3-diamine)
• 113305-94-5(5-aminopyrazine-2-carbonitrile)
• 25911-65-3(3-Aminopyrazine-2-carbonitrile)
• 123188-98-7(2,3-Pyrazinedicarbonitrile,5-amino-6-(methylamino)-)
• 133940-72-4(3,6-diamino-2,5-Pyrazinedicarbonitrile)
• 59489-39-3(6-aminopyrazine-2-carbonitrile)