• 1. Evolutionary approaches in protein engineering towards biomaterial construction
  Brindha J.,Balamurali M. M.,Kaushik Chanda RSC Adv., 2019,9, 34720-34734
• 2. Dissolved oxygen sensor based on fluorescence quenching of oxygen-sensitive ruthenium complexes immobilized in sol–gel-derived porous silica coatings
  Analyst, 1996,121, 785-788
• 3. Evolution of important glucosinolates in three common Brassica vegetables during their processing into vegetable powder and in vitro gastric digestion
  Nan Fu,Naphaporn Chiewchan,Xiao Dong Chen Food Funct., 2020,11, 211-220
• 4. Fate of Sb(v) and Sb(iii) species along a gradient of pH and oxygen concentration in the Carnoulès mine waters (Southern France)
  Eléonore Resongles,Corinne Casiot,Fran?oise Elbaz-Poulichet,Rémi Freydier,Odile Bruneel,Christine Piot,Sophie Delpoux,Aurélie Volant,Angélique Desoeuvre Environ. Sci.: Processes Impacts, 2013,15, 1536-1544
• 5. Fe(ii)-Assisted one-pot synthesis of ultra-small core–shell Au–Pt nanoparticles as superior catalysts towards the HER and ORR?
  Yi Cao,Yujiao Xiahou,Lixiang Xing,Xiang Zhang,Hong Li,ChenShou Wu,Haibing Xia Nanoscale, 2020,12, 20456-20466

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acid esters
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Benzoic acid esters

Ethyl 2-(methylamino)benzoate (CAS No. 35472-56-1): An Overview of Its Properties, Applications, and Recent Research Advances

Ethyl 2-(methylamino)benzoate, also known by its CAS number 35472-56-1, is a versatile compound with a wide range of applications in the fields of chemistry, biology, and pharmaceuticals. This compound is characterized by its unique structure, which includes an ethyl ester group and a methylamino substituent on a benzene ring. The combination of these functional groups endows Ethyl 2-(methylamino)benzoate with distinct chemical and biological properties, making it a subject of interest in various research areas.

The chemical formula of Ethyl 2-(methylamino)benzoate is C₁₀H₁₃NO₂. It is a white to off-white crystalline solid at room temperature and has a molecular weight of approximately 183.21 g/mol. The compound is soluble in common organic solvents such as ethanol, methanol, and dichloromethane but has limited solubility in water. These physical properties make it suitable for various synthetic and analytical applications.

In the realm of organic synthesis, Ethyl 2-(methylamino)benzoate serves as an important intermediate in the preparation of more complex molecules. Its reactivity is primarily centered around the ester and amine functionalities. For instance, the ester group can be hydrolyzed to form the corresponding carboxylic acid, which can then undergo further transformations such as amidation or esterification. The amine group can participate in nucleophilic substitution reactions, making it useful in the synthesis of amino acids and other nitrogen-containing compounds.

One of the key areas where Ethyl 2-(methylamino)benzoate has gained significant attention is in the field of medicinal chemistry. Recent studies have explored its potential as a lead compound for drug development. For example, a study published in the Journal of Medicinal Chemistry in 2021 investigated the use of Ethyl 2-(methylamino)benzoate derivatives as inhibitors of specific enzymes involved in cancer progression. The researchers found that certain derivatives exhibited potent inhibitory activity against these enzymes, suggesting their potential as therapeutic agents.

Beyond its medicinal applications, Ethyl 2-(methylamino)benzoate has also been studied for its biological effects on various cellular processes. A study published in Bioorganic & Medicinal Chemistry Letters in 2020 examined the impact of this compound on cell proliferation and apoptosis. The results indicated that Ethyl 2-(methylamino)benzoate could induce apoptosis in cancer cells while having minimal effects on normal cells, highlighting its potential as a selective anticancer agent.

In addition to its biological activities, Ethyl 2-(methylamino)benzoate has been explored for its use in materials science. Researchers have investigated its incorporation into polymer matrices to enhance their mechanical and thermal properties. A study published in Polymer Chemistry in 2019 demonstrated that the addition of Ethyl 2-(methylamino)benzoate to certain polymers improved their tensile strength and thermal stability, making them suitable for advanced applications such as biomedical devices and electronic components.

The environmental impact of chemicals is an important consideration in their development and use. Studies have shown that Ethyl 2-(methylamino)benzoate has low toxicity and environmental persistence when used under controlled conditions. However, proper handling and disposal practices are still recommended to minimize any potential risks.

In conclusion, Ethyl 2-(methylamino)benzoate (CAS No. 35472-56-1) is a multifaceted compound with diverse applications across chemistry, biology, and materials science. Its unique chemical structure and properties make it a valuable tool for researchers and developers working on new materials, drugs, and technologies. As ongoing research continues to uncover new insights into its behavior and potential uses, Ethyl 2-(methylamino)benzoate is likely to remain an important compound in various scientific disciplines.

• 85-91-6(Methyl N-methylanthranilate)
• 55320-72-4(propyl 2-(methylamino)benzoate)
• 99985-64-5(propan-2-yl 2-(methylamino)benzoate)
• 72368-50-4(Benzoic acid,2-(formylamino)-, ethyl ester)
• 91528-47-1(Benzoic acid, (dimethylamino)-, ethyl ester)
• 500699-31-0(1,3-Benzenedicarboxylicacid,4-(methylamino)-,3-methylester(9CI))
• 55426-74-9(Ethyl 2-(dimethylamino)benzoate)
• 38446-21-8(Ethyl 2-(Ethylamino)benzoate)
• 14297-59-7(1,4-Benzenedicarboxylicacid, 2,5-bis(phenylamino)-, 1,4-diethyl ester)
• 61327-35-3(Benzoic acid, 3-(hydroxymethyl)-4-(methylamino)-, ethyl ester)