• 1. Evolution of dealloying induced strain in nanoporous gold crystals?
  Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693
• 2. Fate of Sb(v) and Sb(iii) species along a gradient of pH and oxygen concentration in the Carnoulès mine waters (Southern France)
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• 3. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
  Alexandre Vimont,Arnaud Travert,Philippe Bazin,Jean-Claude Lavalley,Marco Daturi,Christian Serre,Gérard Férey,Sandrine Bourrelly,Philip L. Llewellyn Chem. Commun., 2007, 3291-3293
• 4. Excimer–monomer switch: a reaction-based approach for selective detection of fluoride?
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• 5. Ester-directed orthogonal dual C–H activation and ortho aryl C–H alkenylation via distal weak coordination?
  Manickam Bakthadoss,Tadiparthi Thirupathi Reddy,Vishal Agarwal,Duddu S. Sharada Chem. Commun., 2022,58, 1406-1409

Comprehensive Guide to 1-(1-Phenylethyl)-1H-pyrazol-5-amine (CAS No. 3524-13-8): Properties, Applications, and Market Insights

1-(1-Phenylethyl)-1H-pyrazol-5-amine (CAS No. 3524-13-8) is a specialized organic compound that has garnered significant attention in pharmaceutical and agrochemical research. This pyrazole derivative features a unique molecular structure combining a phenyl group and an amine functionality, making it valuable for various synthetic applications. With the growing interest in heterocyclic compounds for drug discovery, this substance has become a subject of increasing scientific and industrial focus.

The compound's molecular formula is C₁₁H₁₃N₃, with a molecular weight of 187.24 g/mol. Its structural features include a pyrazole ring substituted at the 1-position with a 1-phenylethyl group and at the 5-position with an amino group. This configuration contributes to its potential as a building block in medicinal chemistry, particularly for developing kinase inhibitors and other bioactive molecules. Researchers are particularly interested in its potential as a precursor for pharmaceutical intermediates due to its versatile reactivity.

Recent studies have explored the application of 1-(1-Phenylethyl)-1H-pyrazol-5-amine in the development of novel therapeutic agents. The compound's structural similarity to known bioactive molecules makes it promising for targeting various biological pathways. In the context of current pharmaceutical trends focusing on personalized medicine and targeted therapies, this pyrazole derivative offers interesting possibilities for drug design and optimization.

From a synthetic chemistry perspective, 3524-13-8 serves as an important intermediate in organic synthesis. Its reactivity allows for various transformations, including coupling reactions and functional group interconversions. The presence of both aromatic and amine functionalities makes it particularly valuable for creating diverse molecular architectures. Many researchers are investigating its use in multi-component reactions, which are currently a hot topic in green chemistry and sustainable synthesis methodologies.

The agrochemical industry has also shown interest in 1-(1-Phenylethyl)-1H-pyrazol-5-amine derivatives for developing new crop protection agents. With increasing global concerns about food security and sustainable agriculture, compounds with this structural motif are being evaluated for their potential pesticidal or herbicidal activities. The pyrazole core is known to impart favorable properties to agrochemicals, including stability and bioavailability.

Market analysis indicates growing demand for specialized heterocyclic building blocks like 3524-13-8, particularly in the pharmaceutical and biotechnology sectors. The compound's commercial availability has increased in recent years to meet research needs, with several specialty chemical suppliers now offering it in various quantities. Current pricing trends reflect its status as a research-grade material with potential for scale-up as applications develop.

Quality control aspects of 1-(1-Phenylethyl)-1H-pyrazol-5-amine are crucial for research applications. Analytical methods typically employed include HPLC for purity assessment and NMR for structural confirmation. The compound is generally supplied as a solid with specified purity levels, and proper storage conditions are essential to maintain its stability over time. These quality considerations are particularly important given the compound's use in sensitive pharmaceutical research.

From a regulatory perspective, CAS 3524-13-8 is not currently classified under major chemical control regulations, making it accessible for research purposes. However, researchers should always consult local regulations and implement appropriate safety measures when handling any laboratory chemicals. The compound's safety profile is typical of aromatic amines, requiring standard laboratory precautions.

The future outlook for 1-(1-Phenylethyl)-1H-pyrazol-5-amine appears promising, with potential applications expanding as research continues. The growing interest in small molecule therapeutics and the continuous need for novel chemical entities in drug discovery suggest that this compound and its derivatives will remain relevant in medicinal chemistry. Additionally, its potential applications in materials science and other specialized fields may emerge as research progresses.

For researchers working with pyrazole derivatives, understanding the properties and potential of 3524-13-8 can provide valuable insights for project development. The compound represents an interesting case study in how relatively simple heterocyclic structures can serve as versatile platforms for diverse applications across multiple scientific disciplines.

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