• 1. Acentric and chiral heterometallic inorganic–organic hybrid frameworks mediated by alkali or alkaline earth ions: synthesis and NLO properties
  Huabin Zhang,Shaowu Du CrystEngComm, 2014,16, 4059-4068
• 2. Aggregation-induced chiral symmetry breaking of a naphthalimide–cyanostilbene dyad?
  Xin Li,Liangliang Zhu,Sai Duan,Yanli Zhao,Hans ?gren Phys. Chem. Chem. Phys., 2014,16, 23854-23860
• 3. Aluminium alkyl and aryloxide complexes of pyrazine and bipyridines: synthesis and structure?
  Doug Ogrin,Laura H. van Poppel,Simon G. Bott,Andrew R. Barron Dalton Trans., 2004, 3689-3694
• 4. An atom efficient route to N-aryl and N-alkyl pyrrolines by transition metal catalysis?
  Supaporn Sawadjoon,Joseph S. M. Samec Org. Biomol. Chem., 2011,9, 2548-2554
• 5. An assessment of strategies for the development of solid-state adsorbents for vehicular hydrogen storage
  Mark D. Allendorf,Alauddin Ahmed,Tom Autrey,Jeffrey Camp,Eun Seon Cho,Maciej Haranczyk,Abhi Karkamkar,Di-Jia Liu,Katie R. Meihaus,Iffat H. Nayyar,Roman Nazarov,Donald J. Siegel,Vitalie Stavila,Jeffrey J. Urban,Srimukh Prasad Veccham,Brandon C. Wood Energy Environ. Sci., 2018,11, 2784-2812

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Benzoic acids

3,4-Dichlorobenzoic-d3 Acid: A Comprehensive Overview

3,4-Dichlorobenzoic-d3 Acid, also known as d3-3,4-Dichlorobenzoic Acid, is a specialized compound with the CAS number 350818-53-0. This compound is a deuterated derivative of 3,4-dichlorobenzoic acid, where three hydrogen atoms have been replaced with deuterium atoms. The substitution of hydrogen with deuterium is a common practice in various scientific fields, particularly in analytical chemistry and pharmaceutical research, to enhance the compound's stability and improve its detectability in spectroscopic analyses.

The structure of 3,4-Dichlorobenzoic-d3 Acid consists of a benzoic acid backbone with two chlorine atoms attached at the 3 and 4 positions of the benzene ring. The deuterium substitution occurs at specific positions on the molecule, which can influence its physical and chemical properties. This compound is widely used in research settings due to its unique properties and applications in areas such as drug metabolism studies, environmental analysis, and material science.

Recent advancements in the synthesis and application of d3-3,4-Dichlorobenzoic Acid have been documented in various scientific journals. For instance, researchers have explored its potential as a stable isotopic tracer in pharmacokinetic studies. By incorporating deuterium into the molecule, scientists can track the compound's behavior within biological systems more accurately. This has significant implications for drug development, where understanding the metabolism and elimination pathways of compounds is crucial.

In addition to its role in pharmaceutical research, 3,4-Dichlorobenzoic-d3 Acid has found applications in environmental science. It is used as a reference standard in mass spectrometry-based analyses to detect and quantify trace levels of pollutants in water and soil samples. The deuterium substitution enhances the compound's stability under harsh analytical conditions, making it an ideal choice for these applications.

The synthesis of d3-3,4-Dichlorobenzoic Acid involves a multi-step process that typically includes chlorination of benzoic acid followed by deuteration at specific positions. Recent studies have focused on optimizing these synthesis pathways to improve yield and purity. For example, researchers have employed novel catalysts and reaction conditions to achieve higher efficiency in the deuteration step.

The physical properties of 3,4-Dichlorobenzoic-d3 Acid include a melting point of approximately 210°C and a molecular weight of 216.5 g/mol. Its solubility characteristics make it suitable for use in various solvents commonly employed in analytical chemistry. The compound is also known for its thermal stability, which is advantageous for long-term storage and repeated use in experiments.

In terms of safety considerations, while d3-3,4-Dichlorobenzoic Acid is not classified as a hazardous material under normal handling conditions, it is essential to follow standard laboratory protocols when working with this compound. Proper ventilation and personal protective equipment should be used to minimize exposure risks.

The demand for 3,4-Dichlorobenzoic-d3 Acid has grown significantly due to its versatility across multiple scientific disciplines. Its role as a stable isotopic tracer has made it indispensable in modern research environments. As technological advancements continue to refine its synthesis and application methods, this compound will likely remain a valuable tool for scientists worldwide.

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