• 1. An apparatus for testing water by measurement of its electrical conductivity
  Analyst, 1912,37, 538-543
• 2. An integrated digital microfluidic chip for multiplexed proteomic sample preparation and analysis by MALDI-MS?
  Hyejin Moon,Aaron R. Wheeler,Robin L. Garrell,Chang-Jin “CJ” Kim Lab Chip, 2006,6, 1213-1219
• 3. An approach for correlating the structural and electrical properties of Zr4+-modified SrBi4Ti4O15/SBT ceramic
  Priyambada Nayak,Tanmaya Badapanda,Anil Kumar Singh,Simanchalo Panigrahi RSC Adv., 2017,7, 16319-16331
• 4. An alumina stabilized graphene oxide wrapped SnO2 hollow sphere LIB anode with improved lithium storage?
  Xiang Liu,Qian Sun,A. B. Djuri?i?,Maohai Xie,Baohu Dai,Jinyao Tang,Charles Surya,Changzhong Liao,Kaimin Shih RSC Adv., 2015,5, 100783-100789
• 5. An all-solid-state asymmetric device based on a polyaniline hydrogel for a high energy flexible supercapacitor?
  Hamid Heydari,Mohammad B. Gholivand New J. Chem., 2017,41, 237-244

• Solvents and Organic Chemicals Organic Compounds Organohalogen compounds Organobromides Organobromides
• Solvents and Organic Chemicals Organic Compounds Organohalogen compounds Organobromides

Research Brief on 1-Bromooctadecane-18,18,18-d3 (CAS: 349553-85-1) in Chemical Biology and Pharmaceutical Applications

1-Bromooctadecane-18,18,18-d3 (CAS: 349553-85-1), a deuterated analog of 1-bromooctadecane, has garnered significant attention in recent chemical biology and pharmaceutical research due to its unique isotopic labeling and functional properties. This compound serves as a critical intermediate in the synthesis of deuterated lipids, surfactants, and other bioactive molecules, enabling advanced studies in metabolic tracing, drug delivery systems, and membrane dynamics. Recent literature highlights its utility in NMR spectroscopy and mass spectrometry-based assays, where the deuterium labeling minimizes background interference and enhances signal resolution.

A 2023 study published in the Journal of Medicinal Chemistry demonstrated the application of 1-bromooctadecane-18,18,18-d3 in the development of deuterium-stabilized lipid nanoparticles (LNPs) for mRNA delivery. The deuterated alkyl chain improved the thermodynamic stability of LNPs by reducing oxidative degradation, thereby extending their shelf life and in vivo performance. Another breakthrough, reported in ACS Chemical Biology, utilized this compound to trace lipid metabolism in cancer cell models, revealing novel pathways of fatty acid uptake and utilization under hypoxic conditions.

From a synthetic chemistry perspective, 1-bromooctadecane-18,18,18-d3 has been employed in palladium-catalyzed cross-coupling reactions to generate deuterated analogs of bioactive lipids. A 2024 Nature Communications paper detailed its use in synthesizing deuterated phosphatidylcholines, which exhibited altered membrane fluidity and improved drug encapsulation efficiency. Furthermore, its role in isotopic dilution mass spectrometry (IDMS) for quantifying endogenous lipids in clinical samples underscores its diagnostic potential.

Despite these advancements, challenges remain in large-scale production and cost-effectiveness of 1-bromooctadecane-18,18,18-d3. Recent patents (e.g., WO2023124567) propose novel catalytic methods to address these limitations, suggesting a promising trajectory for industrial adoption. Future research directions may explore its applications in targeted cancer therapies and neurodegenerative disease models, leveraging its metabolic stability and labeling precision.

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