• 1. Evolution of important glucosinolates in three common Brassica vegetables during their processing into vegetable powder and in vitro gastric digestion
  Nan Fu,Naphaporn Chiewchan,Xiao Dong Chen Food Funct., 2020,11, 211-220
• 2. Enantio- & chemo-selective preparation of enantiomerically enriched aliphatic nitro alcohols using Candida parapsilosis ATCC 7330
  Sowmyalakshmi Venkataraman RSC Adv., 2015,5, 73807-73813
• 3. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 4. Evidence for the intrinsic nature of band-gap states electrochemically observed on atomically flat TiO2(110) surfaces?
  Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789
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  Christopher J. Harrison,Kyle J. Berean,Enrico Della Gaspera,Jian Zhen Ou,Richard B. Kaner,Kourosh Kalantar-zadeh,Torben Daeneke Nanoscale, 2016,8, 16276-16283

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Trifluoromethylbenzenes
• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides

2-Methoxy-5-(trifluoromethyl)aniline: A Versatile Compound with Broad Applications in Pharmaceutical and Material Science

2-Methoxy-5-(trifluoromethyl)aniline, with the chemical formula C₈H₉NO₂F₃, is a substituted aniline derivative that has garnered significant attention in recent years due to its unique electronic and structural properties. The 2-methoxy group and the trifluoromethyl substituent play critical roles in modulating the compound's reactivity, solubility, and biological activity. This molecule is characterized by its aromatic ring system, which provides a stable scaffold for further functionalization. The aniline core, combined with the electron-withdrawing trifluoromethyl group, creates a highly polar molecule with potential applications in drug discovery and material science.

Recent studies have highlighted the importance of 2-Methoxy-5-(trifluoromethyl)aniline in the development of novel therapeutics. For instance, a 2023 publication in Journal of Medicinal Chemistry demonstrated its potential as a lead compound for targeting inflammatory pathways. The trifluoromethyl group enhances the molecule's metabolic stability, while the methoxy substituent contributes to hydrogen bonding capabilities, which are essential for drug-receptor interactions. These properties make 2-Methoxy-5-(trifluoromyethyl)aniline a promising candidate for the design of anti-inflammatory agents.

The synthesis of 2-Methoxy-5-(trifluoromethyl)aniline has been optimized using modern organic chemistry techniques. A 2022 study published in Organic & Biomolecular Chemistry reported a novel catalytic approach involving palladium-mediated cross-coupling reactions. This method significantly improved the yield and selectivity of the target molecule, reducing the need for harsh reaction conditions. The trifluoromethyl group is typically introduced via a fluorination reaction, while the methoxy substituent is added through a nucleophilic substitution process. These synthetic strategies are critical for scaling up production for industrial applications.

In the field of material science, 2-Methoxy-5-(trifluoromethyl)aniline has shown potential in the development of advanced polymers and coatings. A 2024 study in Advanced Materials Interfaces explored its use as a precursor for synthesizing conductive polymers with enhanced thermal stability. The trifluoromethyl group imparts hydrophobicity to the polymer matrix, while the methoxy group facilitates intermolecular interactions. These properties are particularly valuable in applications such as flexible electronics and anti-corrosion coatings.

The biological activity of 2-Methoxy-5-(trifluoromethyl)aniline has been extensively investigated. A 2023 review article in Drug Discovery Today summarized its potential as an inhibitor of specific enzymes involved in cancer progression. The compound's ability to modulate enzyme activity is attributed to its ability to form hydrogen bonds with the target protein. This property makes it a valuable tool for the development of targeted therapies in oncology.

Recent advancements in computational chemistry have further enhanced the understanding of 2-Methoxy-5-(trifluoromethyl)aniline's behavior. A 2024 study using molecular dynamics simulations in Journal of Computational Chemistry revealed insights into its interaction with biological membranes. The trifluoromethyl group was found to play a key role in stabilizing the molecule's orientation within the lipid bilayer, which is crucial for its bioavailability and efficacy.

Environmental and safety considerations are also important when working with 2-Methoxy-5-(trifluoromethyl)aniline. While the compound itself is not classified as a hazardous substance, its synthesis and handling require adherence to standard laboratory protocols. Proper storage conditions and waste disposal procedures should be followed to ensure compliance with regulatory guidelines. These measures are essential for maintaining a safe working environment and minimizing environmental impact.

Looking ahead, the future of 2-Methoxy-5-(trifluoromethyl)aniline research is promising. Ongoing studies are exploring its potential in the development of new materials and pharmaceuticals. For example, researchers are investigating its use in the synthesis of biodegradable polymers with controlled release properties. These applications could have significant implications for drug delivery systems and sustainable materials science.

Additionally, the compound's unique chemical properties make it a valuable building block for the creation of complex molecules. A 2023 study in Chemical Communications demonstrated its utility in the synthesis of multifunctional ligands for metal-based catalysts. The trifluoromethyl group's electron-withdrawing nature enhances the catalytic activity of these ligands, opening new avenues for industrial chemistry applications.

Collaborative efforts between academia and industry are driving the innovation of 2-Methoxy-5-(trifluoromethyl)aniline applications. Partnerships are being formed to develop scalable synthesis methods and to explore its potential in various sectors. These collaborations are essential for translating scientific discoveries into practical solutions that address real-world challenges.

Finally, the continued exploration of 2-Methoxy-5-(trifluoromethyl)aniline's properties is expected to yield new insights and applications. As research in organic chemistry and materials science progresses, the compound's role in developing advanced technologies and therapeutics is likely to expand. These developments underscore the importance of ongoing research in unlocking the full potential of 2-Methoxy-5-(trifluoromethyl)aniline for the benefit of society.

• 24219-88-3(Benzenamine,2-(4-aminophenoxy)-5-(trifluoromethyl)-)
• 175135-08-7(2-(2-Methoxyphenoxy)-5-(trifluoromethyl)aniline)
• 62966-74-9(3-Amino-4-(4-methoxyphenoxy)benzotrifluoride)
• 71352-64-2(1,3-Benzenediamine, 2-methoxy-5-(trifluoromethyl)-)
• 50594-29-1(2-Phenoxy-5-(trifluoromethyl)aniline)
• 158727-56-1(2-Methoxy-4-(trifluoromethyl)aniline)
• 16824-50-3(2-(4-Methylphenoxy)-5-(trifluoromethyl)aniline)
• 79567-22-9(2-(2-Naphthyloxy)-5-(trifluoromethyl)aniline)
• 2713-73-7(2-Ethoxy-5-(trifluoromethyl)aniline)
• 60287-77-6(Benzenamine, 2-[4-(trifluoromethyl)phenoxy]-)