Cas no 3445-11-2 (1-(2-Hydroxyethyl)pyrrolidin-2-one)

1-(2-Hydroxyethyl)pyrrolidin-2-one is a versatile cyclic amide derivative with a hydroxyl-functionalized side chain, offering unique solvation and reactivity properties. Its polar structure, combining a pyrrolidinone ring and a hydroxyethyl group, enhances solubility in both aqueous and organic media, making it valuable as a solvent or intermediate in pharmaceutical and chemical synthesis. The compound’s dual functionality allows for further derivatization, enabling applications in polymer modification, drug delivery systems, and specialty chemical formulations. Its stability under mild conditions and compatibility with a range of reagents underscore its utility in controlled reactions. The product is particularly noted for its low toxicity and favorable environmental profile compared to traditional solvents.
1-(2-Hydroxyethyl)pyrrolidin-2-one structure
3445-11-2 structure
Product Name:1-(2-Hydroxyethyl)pyrrolidin-2-one
CAS No:3445-11-2
MF:C6H11NO2
MW:129.157041788101
MDL:MFCD00014103
CID:44168
PubChem ID:76980
Update Time:2025-05-23

1-(2-Hydroxyethyl)pyrrolidin-2-one Chemical and Physical Properties

Names and Identifiers

    • 1-(2-Hydroxyethyl)pyrrolidin-2-one
    • N-HYDROXYETHYL PYRROLIDONE
    • 1-(2-HYDROXYETHYL)-2-PYRROLIDINONE
    • 1-(2-HYDROXYETHYL)-2-PYRROLIDONE
    • (2-hydroxyethyl)-2-pyrrolidone
    • 1-(2-hydroxyethyl)-2-pyrrolidinon
    • 2-Pyrrolidinone, 1-(2-hydroxyethyl)-
    • N-2-Hydroxyethylpyrrolidin-2-one-
    • N-(2-hydroxyethyl)-2-Pyrrolidinone
    • 2-Pyrrolidinone,1-(2-hydroxyethyl)
    • EINECS 222-359-4
    • N-(2-hydroxyethyl)-2-oxo-pyrrolidine
    • N-(2-Hydroxyethyl)-2-pyrrolidone
    • N-(2-hydroxyethyl)-pyrrolidinone
    • N-2-Hydroxyethylpyrrolidin-2-one
    • WDQFELCEOPFLCZ-UHFFFAOYSA-N
    • 297G099QOU
    • 1-(2-hydroxy-ethyl)-pyrrolidin-2-one
    • n-hydroxyethylpyrrolidone
    • DSSTox_RID_80588
    • DSSTox_CID_24922
    • DSSTox_GSID_44922
    • KSC494Q8L
    • 2-hydoxyethyl-pyrrolidin-2-one
    • 2-(2-pyr
    • N-(2-hydroxyethyl)-pyrrolidin-2-one
    • ?N-(2-Hydroxyethyl)-2-pyrrolidone
    • 1-(2-HYDROXYETHYL)-2-OXOPYRROLIDINE
    • N-(.BETA.-HYDROXYETHYL)-2-PYRROLIDINONE
    • 2-hydroxy-ethyl-pyrrolidin-2-one
    • 1-(2-Hydroxyethyl)-2-pyrrolidone, 98%
    • InChI=1/C6H11NO2/c8-5-4-7-3-1-2-6(7)9/h8H,1-5H2
    • BRN 0112181
    • FG-0408
    • 2-(2-pyrrolidon-1-yl)ethanol
    • 2-(2-oxo-pyrrolidin-1-yl)-ethanol
    • DTXCID5024922
    • 1-(2-HYDROXYLETHYL)-2-PYRROLIDONE
    • N-(.BETA.-HYDROXYETHYL)-2-PYRROLIDONE
    • N-(2-HYDROXYETHYL)PYRROLIDONE
    • CAS-3445-11-2
    • NCGC00256132-01
    • Q27254401
    • AKOS000119587
    • FT-0629136
    • EN300-20494
    • UNII-297G099QOU
    • CHEMBL3185308
    • 1-(.BETA.-HYDROXYETHYL)-2-PYRROLIDONE
    • WDQFELCEOPFLCZ-UHFFFAOYSA-
    • 1-(2-hydroxyethyl)-pyrrolidin-2-one
    • HYDROXYETHYL)-2-PYRROLIDINONE, 1-(2-
    • MFCD00014103
    • SCHEMBL39045
    • 1-(2-hydroxy-ethyl)-2-pyrrolidone
    • AT12426
    • NS00005193
    • 2-Pyrrolidinone, 1-(2-hydroxyethyl)
    • A822241
    • CS-W009539
    • Z104478410
    • H0408
    • EC 222-359-4
    • SY031232
    • W-106735
    • 2-(2-oxopyrrolidin-1-yl)ethanol
    • 3445-11-2
    • Tox21_301700
    • DTXSID7044922
    • 5-21-06-00341 (Beilstein Handbook Reference)
    • N(2Hydroxyethyl)2pyrrolidone
    • N-(BETA-HYDROXYETHYL)-2-PYRROLIDONE
    • N-(BETA-HYDROXYETHYL)-2-PYRROLIDINONE
    • 1(2Hydroxyethyl)pyrrolidin2one
    • 2Pyrrolidinone, 1(2hydroxyethyl)
    • 1-(BETA-HYDROXYETHYL)-2-PYRROLIDONE
    • 1(2Hydroxyethyl)2pyrrolidone
    • ALBB-014609
    • N2Hydroxyethylpyrrolidin2one
    • DB-030069
    • FH38965
    • MDL： MFCD00014103
    • Inchi： 1S/C6H11NO2/c8-5-4-7-3-1-2-6(7)9/h8H,1-5H2
    • InChI Key： WDQFELCEOPFLCZ-UHFFFAOYSA-N
    • SMILES： O=C1CCCN1CCO
    • BRN： 0112181

Computed Properties

  • Exact Mass: 129.07900
  • Monoisotopic Mass: 129.079
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 9
  • Rotatable Bond Count: 2
  • Complexity: 114
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: 2
  • XLogP3: -0.8
  • Topological Polar Surface Area: 40.5

Experimental Properties

  • Color/Form: Yellow solid or liquid
  • Density: 1.143?g/mL?at 25?°C(lit.)
  • Melting Point: 19-21°C
  • Boiling Point: 175°C/10mmHg(lit.)
  • Flash Point: Fahrenheit: 212 ° f
    Celsius: 100 ° c
  • Refractive Index: n20/D 1.496(lit.)
  • Stability/Shelf Life: Stable. Incompatible with strong oxidizing agents
  • PSA: 40.54000
  • LogP: -0.46100
  • Solubility: Not determined

1-(2-Hydroxyethyl)pyrrolidin-2-one Security Information

  • Symbol: GHS07
  • Prompt：warning
  • Signal Word：Warning
  • Hazard Statement： H315,H319,H335
  • Warning Statement： P261,P305+P351+P338
  • Hazardous Material transportation number：NONH for all modes of transport
  • WGK Germany：2
  • Hazard Category Code： 36/37/38
  • Safety Instruction： S26-S36
  • RTECS：UY5776500
  • Hazardous Material Identification： Xi
  • Safety Term：S26
  • HazardClass：IRRITANT
  • Risk Phrases：R36/37/38
  • Storage Condition：Keep it tightly closed. Store in a cool, dry place.

1-(2-Hydroxyethyl)pyrrolidin-2-one Customs Data

  • HS CODE：2933790090
  • Customs Data：

    China Customs Code:

    2933790090

    Overview:

    2933790090 Other lactams. VAT:17.0% Tax refund rate:9.0% Regulatory conditions:nothing MFN tariff:9.0% general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

1-(2-Hydroxyethyl)pyrrolidin-2-one Pricemore >>

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1-(2-Hydroxyethyl)pyrrolidin-2-one Suppliers

Tiancheng Chemical (Jiangsu) Co., Ltd
Gold Member
Audited Supplier Audited Supplier
(CAS:3445-11-2)N-(2-Hydroxyethyl)-2-pyrrolidone
Order Number:LE8494;LE2473149
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 11:59
Price ($):discuss personally

1-(2-Hydroxyethyl)pyrrolidin-2-one Related Literature

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Additional information on 1-(2-Hydroxyethyl)pyrrolidin-2-one

Comprehensive Overview of 1-(2-Hydroxyethyl)pyrrolidin-2-one (CAS No. 3445-11-2): Properties, Applications, and Industry Trends

1-(2-Hydroxyethyl)pyrrolidin-2-one (CAS No. 3445-11-2), also known as HEP, is a versatile organic compound widely utilized in pharmaceuticals, cosmetics, and industrial applications. This pyrrolidone derivative is gaining attention due to its unique solvent properties, biocompatibility, and role in enhancing drug delivery systems. With the increasing demand for green solvents and sustainable chemicals, researchers are exploring its potential as an eco-friendly alternative to traditional solvents like N-methyl-2-pyrrolidone (NMP).

The molecular structure of 1-(2-Hydroxyethyl)pyrrolidin-2-one combines a pyrrolidone ring with a hydroxyethyl group, granting it exceptional solubility for polar and non-polar compounds. This dual functionality makes it invaluable in pharmaceutical formulations, where it acts as a penetration enhancer for topical creams and transdermal patches. Recent studies highlight its efficacy in improving the bioavailability of poorly soluble APIs, aligning with the industry's focus on drug solubility enhancement techniques.

In the cosmetic industry, HEP is prized for its humectant properties and low irritation potential. As consumers prioritize clean beauty and hypoallergenic ingredients, formulators are incorporating this compound into serums and moisturizers. Its ability to stabilize emulsions while maintaining skin hydration responds to trending searches for "non-comedogenic moisturizing agents" and "vegan-friendly cosmetic additives."

Industrial applications leverage 1-(2-Hydroxyethyl)pyrrolidin-2-one as a high-boiling-point solvent for polymer processing and coating formulations. With the rise of electric vehicles (EVs), its role in battery electrolyte systems is under investigation, particularly for lithium-ion battery components. This aligns with global searches for "energy storage materials" and "EV battery innovations."

Synthetic routes to produce CAS No. 3445-11-2 typically involve the reaction of 2-pyrrolidinone with ethylene oxide, followed by purification. Manufacturers are optimizing processes to meet REACH compliance standards, addressing the growing demand for transparent supply chains in specialty chemicals. Analytical techniques like HPLC and GC-MS ensure batch-to-batch consistency, crucial for GMP-certified production.

Emerging research explores HEP's potential in biodegradable plastics and 3D printing resins, responding to circular economy initiatives. Its low volatility and high thermal stability make it suitable for high-temperature applications, a feature frequently queried in technical forums about "heat-resistant solvent alternatives." Environmental studies confirm its readily biodegradable nature per OECD 301 standards.

Quality specifications for 1-(2-Hydroxyethyl)pyrrolidin-2-one typically require ≥98% purity, with strict limits on residual solvents. Storage recommendations emphasize protection from moisture and oxidation, using nitrogen-blanketed containers for long-term stability. These protocols address common purchaser inquiries about "chemical shelf life extension" and "best practices for hygroscopic compounds."

The global market for pyrrolidone derivatives is projected to grow at 5.8% CAGR through 2030, driven by Asia-Pacific pharmaceutical expansion. Regulatory landscapes continue evolving, with 1-(2-Hydroxyethyl)pyrrolidin-2-one being evaluated under EPA Safer Choice criteria. This positions the compound favorably against searches for "EPA-approved green chemistry solutions."

Future applications may include agricultural adjuvants and biocatalyst media, leveraging its amphiphilic character. Patent analyses reveal growing IP activity around HEP-based formulations, particularly for ophthalmic drug delivery systems. These developments answer niche queries about "ocular penetration enhancers" in medical research communities.

In summary, CAS No. 3445-11-2 represents a multifunctional chemical bridging pharmaceutical innovation and industrial sustainability. Its alignment with green chemistry principles and formulation science advancements ensures continued relevance across multiple high-growth sectors, making it a compound of significant scientific and commercial interest.

3445-11-2 (1-(2-Hydroxyethyl)pyrrolidin-2-one) Related Products

Recommended suppliers
Tiancheng Chemical (Jiangsu) Co., Ltd
(CAS:3445-11-2)N-(2-Hydroxyethyl)-2-pyrrolidone
LE8494;LE2473149
Purity:99%/99%
Quantity:25KG,200KG,1000KG/25KG,200KG,1000KG
Price ($):Inquiry/Inquiry
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