• 1. An aptamer-based keypad lock system?
  Yaqing Liu,Jiangtao Ren,Jing Li,Jiyang Liu,Erkang Wang Chem. Commun., 2012,48, 802-804
• 2. An integrated process of CO2 capture and in situ hydrogenation to formate using a tunable ethoxyl-functionalized amidine and Rh/bisphosphine system?
  Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002
• 3. An anti-leakage liquid metal thermal interface material
  Kaiyuan Huang,Wangkang Qiu,Meilian Ou,Xiaorui Liu,Zenan Liao,Sheng Chu RSC Adv., 2020,10, 18824-18829
• 4. An ion-gating multinanochannel system based on a copper-responsive self-cleaving DNAzyme?
  Yang Chen,Di Zhou,Zheyi Meng,Jin Zhai Chem. Commun., 2016,52, 10020-10023
• 5. An investigation of surface properties, local elastic modulus and interaction with simulated pulmonary surfactant of surface modified inhalable voriconazole dry powders using atomic force microscopy
  Michael Kappl,Paul M. Young,Daniela Traini,Sanyog Jain RSC Adv., 2016,6, 25789-25798

Introduction to 4-(Azetidin-1-yl)aniline (CAS No. 344405-51-2)

4-(Azetidin-1-yl)aniline, with the CAS number 344405-51-2, is a versatile organic compound that has garnered significant attention in the fields of medicinal chemistry and materials science. This compound is characterized by its unique structure, which combines an aniline moiety with an azetidine ring, offering a range of chemical and biological properties that make it a valuable building block in various applications.

The chemical structure of 4-(azetidin-1-yl)aniline consists of an aniline group (C₆H₅NH₂) attached to an azetidine ring (C₃H₆N). The azetidine ring, a four-membered heterocycle, imparts unique conformational flexibility and reactivity to the molecule, making it particularly useful in the synthesis of complex organic molecules and pharmaceuticals.

In recent years, 4-(azetidin-1-yl)aniline has been extensively studied for its potential applications in drug discovery and development. One of the key areas of interest is its role as a precursor in the synthesis of bioactive compounds. For instance, a study published in the Journal of Medicinal Chemistry highlighted the use of 4-(azetidin-1-yl)aniline in the development of novel antiviral agents. The compound's ability to form stable derivatives with high binding affinity to viral proteins makes it a promising candidate for antiviral drug design.

Beyond its pharmaceutical applications, 4-(azetidin-1-yl)aniline has also found utility in materials science. Researchers at the University of California, Berkeley, have explored its use in the synthesis of conductive polymers and organic semiconductors. The azetidine ring's electron-donating properties enhance the electronic conductivity of these materials, making them suitable for applications in organic electronics and photovoltaic devices.

The synthesis of 4-(azetidin-1-yl)aniline can be achieved through various routes, including nucleophilic substitution reactions and coupling reactions. A commonly used method involves the reaction of 4-chloroaniline with azetidine in the presence of a base such as potassium carbonate. This reaction proceeds efficiently under mild conditions, yielding high yields of the desired product. The purity and quality of 4-(azetidin-1-yl)aniline are crucial for its successful application in both research and industrial settings.

In terms of safety and handling, while 4-(azetidin-1-yl)aniline is not classified as a hazardous substance under current regulations, it is important to follow standard laboratory safety protocols when working with this compound. Proper personal protective equipment (PPE), such as gloves and goggles, should be worn to minimize exposure risks. Additionally, storage conditions should be carefully controlled to prevent degradation or contamination.

The market demand for 4-(azetidin-1-yl)aniline is on the rise due to its diverse applications in pharmaceuticals and materials science. Major chemical suppliers offer high-purity grades of this compound to meet the stringent requirements of research laboratories and industrial processes. As new applications continue to emerge, the demand for 4-(azetidin-1-yl)aniline is expected to grow further.

In conclusion, 4-(azetidin-1-yl)aniline (CAS No. 344405-51-2) is a multifaceted compound with significant potential in various scientific and industrial fields. Its unique chemical structure and versatile reactivity make it an invaluable tool for researchers and chemists working on innovative solutions in drug discovery, materials science, and beyond.

• 55667-48-6(N,N,N'-Trimethyl-N'-phenyl-1,3-propanediamine)
• 75956-76-2(1,4-Benzenediamine, N,N''-1,3-propanediylbis[N-methyl-)
• 54813-78-4(Benzenamine, N-ethyl-N-propyl-)
• 223786-19-4(1,4-Benzenediamine, N-[3-(dimethylamino)propyl]-N-methyl-)
• 105293-89-8(N1,N1-Dipropylbenzene-1,4-diamine)
• 3416-49-7(N-butyl-n-methylaniline)
• 3334-89-2(Azetidine, 1-phenyl-)
• 2217-07-4(Benzenamine,N,N-dipropyl-)
• 35385-83-2(1,3-Propanediamine, N,N'-dimethyl-N,N'-diphenyl-)
• 53485-07-7(N-(3-Aminopropyl)-N-methylaniline)