• 1. The 2-phenylbenzimidazole-5-sulfonate/layered double hydroxide co-intercalation composite and its luminescence response to nucleotides
  Shufang Zheng,Jun Lu,Wu Li,Yumei Qin,Dongpeng Yan,David G. Evans,Xue Duan J. Mater. Chem. C 2014 2 5161

• Solvents and Organic Chemicals Organic Compounds Nucleosides, nucleotides, and analogues Pyrimidine nucleotides Pyrimidine ribonucleoside diphosphates
• Solvents and Organic Chemicals Organic Compounds Nucleosides, nucleotides, and analogues Pyrimidine nucleotides Pyrimidine ribonucleotides Pyrimidine ribonucleoside diphosphates
• Solvents and Organic Chemicals Organic Compounds Acids/Esters
• Other Chemical Reagents

Cytidine 5'-Diphosphate Trisodium Salt Hydrate: A Comprehensive Overview

Cytidine 5'-diphosphate trisodium salt hydrate, also known as CAS No. 34393-59-4, is a critical nucleotide derivative with significant applications in molecular biology, biotechnology, and pharmaceutical research. This compound, often abbreviated as Cdp or CyD, plays a pivotal role in various biochemical processes, particularly in the synthesis of nucleic acids and the regulation of cellular signaling pathways. Its importance in modern scientific research is underscored by its widespread use in laboratories and its integration into cutting-edge therapeutic developments.

The structural composition of Cytidine 5'-diphosphate trisodium salt hydrate is characterized by its nucleoside backbone, which consists of a cytosine base attached to a ribose sugar moiety. The diphosphate group (PP) at the 5' position of the ribose sugar facilitates its role as a high-energy phosphate donor in biochemical reactions. The trisodium salt form ensures solubility in aqueous solutions, making it ideal for use in various experimental setups. Recent advancements in synthetic chemistry have enabled the large-scale production of this compound with high purity, further enhancing its utility in research and industrial applications.

One of the most significant breakthroughs involving CAS No. 34393-59-4 is its role in the study of RNA metabolism and gene expression regulation. Researchers have utilized this compound to investigate the mechanisms underlying RNA splicing, translation, and degradation. For instance, studies published in leading journals such as Nature Communications and Cell Reports have demonstrated how cytidine diphosphate derivatives influence the activity of RNA-binding proteins, shedding light on potential therapeutic targets for neurodegenerative diseases like Alzheimer's.

In addition to its role in basic research, Cytidine 5'-diphosphate trisodium salt hydrate has found applications in the development of antiviral therapies. Recent studies have shown that this compound can inhibit viral replication by targeting essential enzymes such as RNA-dependent RNA polymerases. For example, research conducted at the University of California San Francisco has highlighted its potential as a broad-spectrum antiviral agent against emerging pathogens like Zika virus and coronaviruses.

The versatility of CAS No. 34393-59-4 extends to its use in biotechnological processes, particularly in the production of recombinant proteins and vaccines. Its ability to serve as a nucleotide donor makes it indispensable in vitro transcription reactions, which are critical for generating synthetic mRNA vaccines. The integration of this compound into vaccine development pipelines has been instrumental in addressing global health challenges, as evidenced by its role during the COVID-19 pandemic.

From an analytical perspective, the characterization of Cytidine 5'-diphosphate trisodium salt hydrate has benefited from advancements in mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy. These techniques have allowed researchers to elucidate its molecular structure with unprecedented precision, enabling the development of more efficient synthetic pathways. Moreover, computational modeling approaches have provided insights into its interaction with biological macromolecules, further enhancing our understanding of its functional properties.

In conclusion, CAS No. 34393-59-4, or Cytidine 5'-diphosphate trisodium salt hydrate, stands as a testament to the synergy between chemical synthesis and biological research. Its diverse applications across multiple disciplines underscore its importance as a foundational tool in modern science. As ongoing research continues to uncover new roles for this compound, it is poised to remain at the forefront of scientific innovation for years to come.

• 81012-87-5(CTP Disodium Dihydrate (>85%))
• 18423-42-2(Cytidine-5'-triphosphoric acid disodium salt)
• 63-38-7(Cytidine 5'-(trihydrogen diphosphate))
• 123334-07-6(Cytidine-5'-triphosphoric Acid Disodium Salt)
• 119629-11-7(Cytidine-5'-diphospho-dimethylaminoethanol Sodium Salt)
• 33818-15-4(citicoline sodium)
• 147258-10-4(RNA formation factor(mouse gene Brn-1 reduced) (9CI))
• 54394-90-0(Sodium 4-amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-5-yl hydrogendiphosphate)
• 36051-68-0(Cytidine 5′-triphosphate (disodium salt))
• 987-78-0(Citicoline)