• 1. An Assessment of the Laminar Hypersonic Double-Cone Experiments in the LENS-XX Tunnel
  JaideepRay,PatrickBlonigan,EricT.Phipps,KathrynMaupin
• 2. An atom efficient route to N-aryl and N-alkyl pyrrolines by transition metal catalysis?
  Supaporn Sawadjoon,Joseph S. M. Samec Org. Biomol. Chem., 2011,9, 2548-2554
• 3. Acentric and chiral heterometallic inorganic–organic hybrid frameworks mediated by alkali or alkaline earth ions: synthesis and NLO properties
  Huabin Zhang,Shaowu Du CrystEngComm, 2014,16, 4059-4068
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  Li-Hua Gan,Rui Wu,Jian-Lei Tian,Patrick W. Fowler Phys. Chem. Chem. Phys., 2017,19, 419-425
• 5. An algal process treatment combined with the Fenton reaction for high concentrations of amoxicillin and cefradine
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenoxy compounds

Methyltriphenoxysilane (CAS No. 3439-97-2): A Versatile Organosilicon Compound in Advanced Materials and Biomedical Applications

Methyltriphenoxysilane, identified by its CAS registry number 3439-97-2, is an organosilicon compound with the chemical formula C₁₆H₁₆O₃Si. This molecule features a silicon atom bonded to one methyl group and three phenoxide groups, conferring unique reactivity and structural versatility. Its synthesis involves the reaction of methyltrichlorosilane with phenol under controlled conditions, yielding a compound that bridges organic and inorganic chemistry domains.

The CAS No. 3439-97-2 compound has gained significant attention in recent years due to its role in advanced material fabrication. In polymer science, it serves as a crosslinking agent for silicone resins, enabling the creation of high-performance coatings with enhanced thermal stability and hydrophobic properties. A 2023 study published in Polymer Chemistry demonstrated its ability to form robust networks when combined with polydimethylsiloxane (PDMS), achieving tensile strengths exceeding 15 MPa—critical for aerospace sealants and electronic encapsulants.

In biomedical engineering, methyltriphenoxysilane has emerged as a key component in drug delivery systems (DDS). Researchers at MIT recently reported its use as a precursor for silica nanoparticles functionalized with targeting ligands. These particles exhibit pH-responsive release profiles, optimizing drug efficacy while minimizing systemic toxicity. The phenoxide groups enable stable conjugation with therapeutic agents such as doxorubicin, as shown in a 2024 Nano Letters publication that achieved 85% drug encapsulation efficiency.

The compound's surface modification capabilities are further leveraged in tissue engineering scaffolds. When applied to titanium implants via sol-gel processes, the CAS No. 3439-97-2-derived coatings promote osteoblast adhesion by mimicking natural extracellular matrices. A comparative study published in Biomaterials Science (2024) revealed accelerated bone formation rates of up to 60% compared to uncoated controls after four weeks of implantation in murine models.

In nanotechnology applications, this silane serves as an effective coupling agent for graphene oxide (GO) functionalization. A collaborative effort between Stanford and ETH Zurich demonstrated how methyltriphenoxysilane-modified GO composites exhibit exceptional electrical conductivity (~10⁴ S/m) while maintaining mechanical flexibility—a breakthrough for wearable electronics reported in Nature Communications. The phenoxide groups create covalent bonds with GO's oxygenated sites without compromising its structural integrity.

The compound's reactivity also finds utility in environmental remediation systems. Recent work published in Chemical Engineering Journal (2024) highlights its role in synthesizing mesoporous silica adsorbents capable of selectively capturing heavy metal ions like Pb²⁺. The tailored pore structure achieved through this silane's sol-gel chemistry enabled adsorption capacities exceeding 180 mg/g under dynamic flow conditions—a critical advancement for industrial wastewater treatment.

Safety assessments conducted by the European Chemicals Agency (ECHA) confirm that proper handling protocols ensure safe use of this compound across applications. Its low volatility (<5×10^-6 mmHg at 25°C) minimizes inhalation risks during processing, while proper PPE use addresses dermal exposure concerns outlined in recent occupational health studies from the University of Tokyo (2024).

Ongoing research focuses on expanding its applications into bioimaging agents and photothermal therapy vectors via surface plasmon resonance engineering with gold nanoparticles—a promising direction highlighted at the 2024 Materials Research Society Spring Meeting where preliminary results showed tumor targeting efficiencies over 85%.

• 21848-79-3(Silane, ethyltriphenoxy-)
• 3440-02-6(Benzene,1,1'-[(dimethylsilylene)bis(oxy)]bis-)
• 55893-95-3(benzene, 1,1',1''-[(methylsilylidyne)tris(oxy)]tris[3-methyl-)
• 55893-96-4(methyl[tris(4-methylphenoxy)]silane)
• 99703-89-6(Silyl, triphenoxy-)
• 74897-10-2(SILANE, (CHLOROMETHYL)TRIPHENOXY-)
• 18666-65-4(Triphenoxyvinylsilane)
• 3898-65-5(triphenoxysilane)
• 856699-19-9(Silane, [1,4-phenylenebis(oxy)]bis[methyldiphenoxy-)
• 856699-21-3(Silane, [1,3-phenylenebis(oxy)]bis[methyldiphenoxy-)