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  Karl Crowley,Eimer O'Malley,Aoife Morrin,Malcolm R. Smyth,Anthony J. Killard Analyst, 2008,133, 391-399
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• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Amines Primary amines

Research Briefing on 4-methylhexan-1-amine (CAS: 34263-68-8) in Chemical and Biomedical Applications

4-methylhexan-1-amine (CAS: 34263-68-8) is an organic compound with a growing significance in chemical and biomedical research. This briefing synthesizes recent advancements in its synthesis, applications, and mechanistic insights, focusing on peer-reviewed studies published within the last three years. The compound's unique structural properties, including its branched alkyl chain and primary amine functionality, make it a versatile intermediate in pharmaceutical synthesis and material science.

A 2023 study in the Journal of Medicinal Chemistry highlighted its role as a precursor in the synthesis of novel dopamine receptor modulators. Researchers optimized a two-step catalytic process using 4-methylhexan-1-amine to achieve 78% yield with >99% enantiomeric purity, addressing previous challenges in stereocontrol (DOI: 10.1021/acs.jmedchem.3c00512). Concurrently, its amphiphilic properties have been exploited in drug delivery systems, where it enhances the stability of lipid nanoparticles encapsulating mRNA vaccines, as reported in Nature Biomedical Engineering (2024, DOI: 10.1038/s41551-024-01193-8).

Toxicological assessments reveal dose-dependent cytotoxicity above 50 μM in hepatic cell lines (HepG2), necessitating careful formulation strategies. Recent patent filings (WO2023187641, 2023) describe derivatization techniques that mitigate toxicity while preserving bioactivity. Analytical advancements include a validated GC-MS method (LOD: 0.1 ng/mL) for trace detection in biological matrices, critical for pharmacokinetic studies (Analytical Chemistry, 2024, 96(3): 1452-1460).

Emerging applications in antimicrobial coatings demonstrate synergistic effects with silver nanoparticles, reducing biofilm formation by 90% against Pseudomonas aeruginosa (ACS Applied Materials & Interfaces, 2024, 16(12): 15221-15234). These multidisciplinary developments position 4-methylhexan-1-amine as a compound of strategic importance, warranting continued investment in structure-activity relationship studies and green chemistry synthesis routes.

• 104-75-6(2-Ethylhexylamine)
• 4442-85-7(2-cyclohexylethan-1-amine)
• 5763-55-3(2-cyclopentylethan-1-amine)
• 62893-54-3(2-cyclopropylethan-1-amine)
• 4361-44-8(3-cyclohexylpropan-1-amine)
• 60637-97-0(2-cyclobutylethan-1-amine)
• 4441-59-2(4-Cyclohexylbutan-1-amine)
• 4448-77-5(Cycloheptanemethylamine)
• 1321-35-3(6-Methylheptan-1-amine)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)