Cas no 3416-26-0 (Lidoflazine)
Lidoflazine is a calcium channel blocker belonging to the diphenylpiperazine class, primarily recognized for its vasodilatory effects. It functions by inhibiting calcium ion influx across cell membranes, leading to relaxation of vascular smooth muscle and subsequent coronary artery dilation. This mechanism makes it relevant in research contexts involving myocardial perfusion and angina management. Lidoflazine exhibits selectivity for vascular tissue, with minimal direct cardiac effects, distinguishing it from other calcium antagonists. Its pharmacokinetic profile includes moderate lipophilicity and prolonged action, supporting sustained pharmacological activity. The compound has been studied for potential applications in ischemia-reperfusion injury due to its ability to modulate cellular calcium homeostasis.
Lidoflazine structure
Product Name:Lidoflazine
CAS No:3416-26-0
MF:C30H35F2N3O
MW:491.615214586258
MDL:MFCD00057353
CID:306452
PubChem ID:3926
Update Time:2025-10-29
Lidoflazine Chemical and Physical Properties
Names and Identifiers
-
- 1-Piperazineacetamide,4-[4,4-bis(4-fluorophenyl)butyl]-N-(2,6-dimethylphenyl)-
- Lidoflazine
- 2-[4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl]-N-(2,6-dimethylphenyl)acetamide
- 4-[4,4-Bis(4-fluorophenyl)butyl]-N-(2,6-dimethylphenyl)-1-piperazineacetamide
- NCGC00016627-02
- 1-(4,4-Bis(4-fluorofenil)butil)-4-((2,6-dimetilanilinocarbonil)metil)piperazina
- HMS3372I14
- 4-(4,4-Bis(p-fluorophenyl)butyl)-1-piperazineaceto-2',6'-xylidide
- D04733
- DTXSID6045377
- LIDOFLAZINE [MART.]
- BSPBio_000561
- CHEMBL92870
- LIDOFLAZINE [INN]
- EINECS 222-312-8
- Corflazine
- NCGC00016627-04
- Lidoflazin
- Prestwick2_000381
- BRD-K62996583-001-03-8
- MCN-JR-7904
- Lidoflazina [Italian]
- Lidoflazine (USAN/INN)
- J4ZHN3HBTE
- Angex
- Lidoflazina [INN-Spanish]
- Klinium
- HMS1569M03
- CS-0043285
- BDBM23619
- Angex (TN)
- ZBIAKUMOEKILTF-UHFFFAOYSA-N
- Prestwick3_000381
- Lidoflazine [USAN:INN:BAN]
- SPBio_002482
- Prestwick1_000381
- NS00010627
- HMS2096M03
- 5-23-02-00297 (Beilstein Handbook Reference)
- Lidoflazine, >=98% (HPLC), powder
- Clinium
- Prestwick0_000381
- HMS2232O16
- Q6543740
- Tox21_110533_1
- LIDOFLAZINE [USAN]
- SCHEMBL79037
- Lidoflazinum
- CCG-220381
- 2-{4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl}-N-(2,6-dimethylphenyl)acetamide
- 2-(4-[4,4-Bis(4-fluorophenyl)butyl]-1-piperazinyl)-N-(2,6-dimethylphenyl)acetamide #
- LIDOFLAZINE [MI]
- 1-Piperazineacetamide, 4-(4,4-bis(4-fluorophenyl)butyl)-N-(2,6-dimethylphenyl)-
- R-7904
- McN-JR 7904
- Lidoflazinum [INN-Latin]
- EN300-25890807
- Lidoflazina
- SR-01000841235
- LIDOFLAZINE [WHO-DD]
- 3416-26-0
- CHEBI:93095
- MLS002153793
- HY-112075
- Tox21_110533
- 1-(4,4-Bis(4-fluorofenil)butil)-4-((2,6-dimetilanilinocarbonil)metil)piperazina [Italian]
- DB13766
- UNII-J4ZHN3HBTE
- Ordiflazine
- BRN 0904339
- R 7904
- HMS3713M03
- AKOS040741955
- BPBio1_000619
- MFCD00057353
- J-019473
- Prestwick_700
- 1-Piperazineacetamide, 4-[4,4-bis(4-fluorophenyl)butyl]-N-(2,6-dimethylphenyl)-
- SR-01000841235-2
- 1-Piperazineaceto-2',6'-xylidide, 4-(4,4-bis(p-fluorophenyl)butyl)-
- DTXCID4025377
- 2-[4-[4,4-bis(4-fluorophenyl)butyl]-1-piperazinyl]-N-(2,6-dimethylphenyl)acetamide
- CAS-3416-26-0
- NCGC00016627-01
- SMR001233173
- McN-JR-7094
- Lidoflazine,98.5%
- BRD-K62996583-001-10-3
-
- MDL： MFCD00057353
- Inchi： 1S/C30H35F2N3O/c1-22-5-3-6-23(2)30(22)33-29(36)21-35-19-17-34(18-20-35)16-4-7-28(24-8-12-26(31)13-9-24)25-10-14-27(32)15-11-25/h3,5-6,8-15,28H,4,7,16-21H2,1-2H3,(H,33,36)
- InChI Key： ZBIAKUMOEKILTF-UHFFFAOYSA-N
- SMILES： FC1C=CC(=CC=1)C(C1C=CC(=CC=1)F)CCCN1CCN(CC(NC2C(C)=CC=CC=2C)=O)CC1
Computed Properties
- Exact Mass: 491.27500
- Monoisotopic Mass: 491.275
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 5
- Heavy Atom Count: 36
- Rotatable Bond Count: 9
- Complexity: 623
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 35.6A^2
- XLogP3: 6
Experimental Properties
- Density: 1.1322 (estimate)
- Melting Point: 159-161°
- Boiling Point: 632.6°Cat760mmHg
- Flash Point: 336.4°C
- Refractive Index: 1.581
- Solubility: DMSO: ≥10mg/mL
- PSA: 35.58000
- LogP: 5.69880
Lidoflazine Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| TRC | L397820-10mg |
Lidoflazine |
3416-26-0 | 10mg |
$ 201.00 | 2023-04-15 | ||
| TRC | L397820-50mg |
Lidoflazine |
3416-26-0 | 50mg |
$ 810.00 | 2023-04-15 | ||
| TRC | L397820-100mg |
Lidoflazine |
3416-26-0 | 100mg |
$ 1568.00 | 2023-04-15 | ||
| ChemScence | CS-0043285-10mg |
Lidoflazine |
3416-26-0 | >98.0% | 10mg |
$860.0 | 2022-04-27 | |
| SHANG HAI TAO SHU Biotechnology Co., Ltd. | T15755-10 mg |
Lidoflazine |
3416-26-0 | 10mg |
￥14060.00 | 2022-04-26 | ||
| MedChemExpress | HY-112075-10mg |
Lidoflazine |
3416-26-0 | 10mg |
￥16500 | 2023-08-31 | ||
| Enamine | EN300-25890807-0.05g |
3416-26-0 | 95% | 0.05g |
$636.0 | 2024-06-18 | ||
| SHENG KE LU SI SHENG WU JI SHU | sc-255253-5 mg |
Lidoflazine, |
3416-26-0 | ≥98% | 5mg |
￥1,354.00 | 2023-07-10 | |
| MedChemExpress | HY-112075-1mg |
Lidoflazine |
3416-26-0 | 1mg |
￥4124 | 2024-04-18 | ||
| MedChemExpress | HY-112075-5mg |
Lidoflazine |
3416-26-0 | 5mg |
￥10312 | 2023-08-31 |
Lidoflazine Suppliers
Amadis Chemical Company Limited
Gold Member
Audited Supplier
(CAS:3416-26-0)Lidoflazine
Order Number:A1026817
Stock Status:in Stock
Quantity:1mg
Purity:99%
Pricing Information Last Updated:Thursday, 29 August 2024 15:34
Price ($):517.0
Email:[email protected]
Lidoflazine Related Literature
-
A. H. Stead,R. Gill,T. Wright,J. P. Gibbs,A. C. Moffat Analyst 1982 107 1106
-
2. Coated wire ion-selective electrodes. Principles and practiceH. Freiser J. Chem. Soc. Faraday Trans. 1 1986 82 1217
-
3. Synthesis of lactam and ketone precursors of 2,7-substituted octahydro-pyrrolo[1,2-a]pyrazines and octahydro-2H-pyrido[1,2-a]pyrazinesStefan Van den Branden,Frans Compernolle,Georges J. Hoornaert J. Chem. Soc. Perkin Trans. 1 1992 1035
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Recommended suppliers
Amadis Chemical Company Limited
(CAS:3416-26-0)Lidoflazine
Purity:99%
Quantity:1mg
Price ($):517.0