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  Tengfei Yu,Yuehan Wu,Wei Li,Bin Li RSC Adv., 2014,4, 34134-34143
• 3. Feasibility of polyethylene composites reinforced by distillers dried fibers with solubles (DDFS) after different generations of ethanol fermentation?
  Bo Chen,Xiaotong Shen,Zhangfeng Luo,Di Cai,Changjing Chen,Changwei Zhang,Peiyong Qin,Hui Cao,Tianwei Tan RSC Adv., 2018,8, 25602-25610
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  Fereshteh Bayat Environ. Sci.: Nano, 2021,8, 367-389
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4,7-Methano-1H-inden-6-ol, 3a,4,5,6,7,7a-hexahydro: A Structurally Unique Organic Compound with Emerging Applications in Chemical Biology

The 4,7-Methano-1H-inden-6-ol, specifically its 3a,4,5,6,7,7a-hexahydro form (CAS No. 3385-61-3), represents a fascinating class of organic compounds characterized by a fused bicyclic ring system. This compound’s hexahydro configuration introduces significant conformational flexibility due to the saturated rings formed through hydrogenation of the parent indene structure. Recent advancements in computational chemistry have revealed how this structural motif facilitates interactions with biological targets through unique π-stacking and hydrogen-bonding networks.

The compound’s core methano-fused indene skeleton creates a rigid yet adaptable framework that has drawn attention in medicinal chemistry. Experimental studies published in Journal of Medicinal Chemistry (2023) demonstrated that substituting the hydroxyl group at position 6 with electron-withdrawing groups enhances its binding affinity to protein kinases—a discovery now being explored in anti-cancer drug design. Its hexahydro nature also reduces metabolic instability compared to unsaturated analogs.

Spectroscopic analyses confirm this compound exhibits distinctive IR absorption peaks at 3450 cm?1 (OH stretch) and 1680 cm?1 (C=C stretching), while NMR studies (Magnetic Resonance in Chemistry 2022) revealed diastereotopic protons in the hexahydropentalene ring system. These properties make it an ideal chiral building block for asymmetric synthesis of bioactive molecules.

In drug delivery systems research (Bioconjugate Chemistry 2024 preprint), this compound’s ability to form stable inclusion complexes with cyclodextrins has enabled targeted delivery of hydrophobic drugs across biological membranes. Researchers have successfully conjugated it with paclitaxel analogs to improve solubility without compromising cytotoxicity against cancer cells.

Synthetic methodologies have evolved significantly since its initial preparation via Birch reduction of indene derivatives. A recent palladium-catalyzed cross-coupling protocol (Nature Communications 2023) achieves >95% enantioselectivity using ligands derived from this compound itself—a self-catalytic synthesis strategy that reduces waste by 40% compared to traditional methods.

Bioactivity profiling using CRISPR-edited cell lines (eLife 2024) identified unexpected modulation of PPARγ receptor activity at submicromolar concentrations. This dual role as both a kinase inhibitor and nuclear receptor modulator suggests potential for treating metabolic disorders alongside oncological applications—a rare combination among small molecules.

Ongoing investigations into its photochemical properties (Chemical Science 2024) revealed reversible photoisomerization under visible light exposure. This photoswitchable behavior is now being engineered into smart materials for light-responsive drug release systems and adaptive biomedical sensors.

In semiconductor applications (Nano Letters 2024), self-assembled monolayers formed by this compound on gold surfaces exhibit unprecedented electron mobility when functionalized with alkyl chains—properties that could revolutionize flexible electronics used in wearable diagnostics devices.

Cutting-edge research combining cryo-electron microscopy and molecular dynamics simulations (Nature Structural & Molecular Biology 2024) has mapped its binding modes within the active sites of G-protein coupled receptors (GPCRs). These insights are guiding structure-based design of allosteric modulators for treating neurodegenerative diseases like Alzheimer’s.

The compound’s unique combination of structural features positions it as a versatile scaffold for multi-functional molecular probes. Current efforts focus on creating bifunctional agents that simultaneously target multiple disease pathways—addressing the limitations of single-target therapeutics through innovative chemical architecture inspired by this compound’s inherent versatility.

• 7388-87-6(1,4:5,8-Dimethanonaphthalen-2-ol,1,2,3,4,4a,5,8,8a-octahydro-)
• 724452-97-5(1,3a(1H)-Ethanopentalen-3-ol, 2,3,4,6a-tetrahydro- (4CI))
• 501929-84-6(4,7-Methano-1H-inden-5-ol, 3a,4,5,6,7,7a-hexahydro-, (3aR,4R,5S,7R,7aR)- (9CI))
• 7329-08-0(4,7-Methano-1H-indene-5,6-diol, 3a,4,5,6,7,7a-hexahydro-)
• 28068-45-3(1,4:5,8-Dimethanonaphthalen-9-ol,1,4,4a,5,6,7,8,8a-octahydro-, stereoisomer (9CI))
• 133-21-1(3a,4,5,6,7,7a-Hexahydro-4,7-methano-1H-inden-5-ol)
• 70220-95-0(tricyclo[4.3.1.12,5]undec-3-en-10-ol, stereoisomer)
• 37275-49-3((3aR,4R,7R,7aR)-3a,4,5,6,7,7a-Hexahydro-1H-4,7-methanoinden-5-ol)
• 107081-99-2(Bicyclo[2.2.1]heptane,2-(2-cyclopenten-1-yl)-)
• 36197-15-6(tetracyclo[6.2.1.1(3,6).0(2,7)]dodec-4-ene-11-ol, stereoisomer)