• 1. Emerging investigator series: heterogeneous reactions of sulfur dioxide on mineral dust nanoparticles: from single component to mixed components?
  Tao Wang,Yangyang Liu,Yue Deng,Hongbo Fu,Jianmin Chen Environ. Sci.: Nano, 2018,5, 1821-1833
• 2. EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis?
  Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739
• 3. Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals?
  Eric Besson,Stéphane Gastaldi,Emily Bloch,Selma Aslan,Hakim Karoui,Olivier Ouari,Micael Hardy Analyst, 2019,144, 4194-4203
• 4. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
  Alexandre Vimont,Arnaud Travert,Philippe Bazin,Jean-Claude Lavalley,Marco Daturi,Christian Serre,Gérard Férey,Sandrine Bourrelly,Philip L. Llewellyn Chem. Commun., 2007, 3291-3293
• 5. Emerging 2D hybrid nanomaterials: towards enhanced sensitive and selective conductometric gas sensors at room temperature
  Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126

Comprehensive Overview of Ethyl 5-chloro-4-methylisoxazole-3-carboxylate (CAS No. 3356-96-5): Properties, Applications, and Industry Insights

Ethyl 5-chloro-4-methylisoxazole-3-carboxylate (CAS No. 3356-96-5) is a specialized organic compound belonging to the isoxazole family, a heterocyclic scaffold widely recognized for its versatility in pharmaceutical and agrochemical applications. This compound features a chloro substituent at the 5-position and a methyl group at the 4-position, coupled with an ethyl carboxylate moiety at the 3-position, making it a valuable intermediate in synthetic chemistry. Its molecular formula, C₇H₈ClNO₃, and precise structural attributes contribute to its reactivity and utility in diverse industrial processes.

In recent years, the demand for isoxazole derivatives like Ethyl 5-chloro-4-methylisoxazole-3-carboxylate has surged due to their role in developing bioactive molecules. Researchers and manufacturers frequently inquire about its synthesis methods, purity standards, and scalability for commercial production. The compound’s thermal stability and solubility profiles (e.g., in organic solvents like ethanol or dichloromethane) are also critical for optimizing reaction conditions, a topic often explored in peer-reviewed journals and patent literature.

From an application standpoint, CAS No. 3356-96-5 serves as a key building block for crop protection agents and pharmaceutical intermediates. Its incorporation into herbicides and fungicides aligns with the growing emphasis on sustainable agriculture, addressing global challenges such as food security and resistance management. Additionally, its potential in drug discovery—particularly for anti-inflammatory and antimicrobial agents—has sparked interest among medicinal chemists, as evidenced by its mention in recent PubMed publications and ACS symposiums.

Quality control and regulatory compliance are paramount for users of Ethyl 5-chloro-4-methylisoxazole-3-carboxylate. Analytical techniques such as HPLC, GC-MS, and NMR spectroscopy are routinely employed to verify its purity (>98%), ensuring consistency in downstream applications. Suppliers often highlight batch-to-batch reproducibility and certificates of analysis (CoA) to meet stringent industry standards, a practice highly valued by buyers in fine chemical markets.

Emerging trends, such as green chemistry and flow synthesis, have further influenced the production and use of this compound. Innovations in catalysis and waste reduction aim to minimize environmental impact while maintaining cost-efficiency—a balance increasingly demanded by ESG-conscious investors and regulators. For instance, solvent-free reactions or biocatalytic routes for synthesizing isoxazole carboxylates are gaining traction, as noted in ScienceDirect articles and industry whitepapers.

In summary, Ethyl 5-chloro-4-methylisoxazole-3-carboxylate (CAS No. 3356-96-5) exemplifies the intersection of synthetic utility and industrial relevance. Its applications span agrochemicals, pharmaceuticals, and material science, driven by ongoing research and technological advancements. For professionals seeking detailed technical data sheets or custom synthesis options, engaging with certified suppliers and academic collaborators remains essential to unlocking its full potential.

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