Cas no 335196-05-9 (2-chloro-8-ethylquinoline-3-carbaldehyde)

2-Chloro-8-ethylquinoline-3-carbaldehyde is a versatile quinoline derivative with a reactive aldehyde functional group at the 3-position and a chloro substituent at the 2-position, along with an ethyl group at the 8-position. This compound serves as a valuable intermediate in organic synthesis, particularly in the preparation of pharmaceuticals, agrochemicals, and functional materials. Its distinct substitution pattern enhances reactivity in condensation and nucleophilic addition reactions, making it useful for constructing complex heterocyclic frameworks. The chloro and aldehyde groups offer multiple sites for further functionalization, enabling tailored modifications for specific applications. High purity and stability under controlled conditions ensure consistent performance in synthetic workflows.
2-chloro-8-ethylquinoline-3-carbaldehyde structure
335196-05-9 structure
Product Name:2-chloro-8-ethylquinoline-3-carbaldehyde
CAS No:335196-05-9
MF:C12H10ClNO
MW:219.666902065277
MDL:MFCD02587932
CID:851967
PubChem ID:11287449
Update Time:2025-11-01

2-chloro-8-ethylquinoline-3-carbaldehyde Chemical and Physical Properties

Names and Identifiers

    • 3-Quinolinecarboxaldehyde, 2-chloro-8-ethyl-
    • 2-Chloro-8-ethyl-quinoline-3-carbaldehyde
    • 2-chloro-8-ethylquinoline-3-carbaldehyde
    • 2-Chloro-8-ethylquinoline-3-carboxaldehyde
    • 2-chloro-8-ethyl-3-formylquinoline
    • 335196-05-9
    • MFCD02587932
    • AKOS000301582
    • Y10256
    • AS-65203
    • 2-chloro-8-ethyl-quinoline-3-carbaldehyde, AldrichCPR
    • DTXSID40461257
    • AB11895
    • EN300-703670
    • CS-0061461
    • SCHEMBL1881135
    • MDL： MFCD02587932
    • Inchi： 1S/C12H10ClNO/c1-2-8-4-3-5-9-6-10(7-15)12(13)14-11(8)9/h3-7H,2H2,1H3
    • InChI Key： OCNAMDQJNZGZIH-UHFFFAOYSA-N
    • SMILES： ClC1=C(C=O)C=C2C=CC=C(CC)C2=N1

Computed Properties

  • Exact Mass: 219.04500
  • Monoisotopic Mass: 219.0450916g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 15
  • Rotatable Bond Count: 2
  • Complexity: 234
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 3.4
  • Topological Polar Surface Area: 30?2

Experimental Properties

  • PSA: 29.96000
  • LogP: 3.26310

2-chloro-8-ethylquinoline-3-carbaldehyde Security Information

  • Hazard Category Code： 22-36
  • Safety Instruction： 26
  • Hazardous Material Identification： Xi
  • HazardClass：IRRITANT

2-chloro-8-ethylquinoline-3-carbaldehyde Customs Data

  • HS CODE：2933499090
  • Customs Data：

    China Customs Code:

    2933499090

    Overview:

    2933499090. Other compounds containing quinoline or isoquinoline ring system [but not further fused]. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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2-chloro-8-ethylquinoline-3-carbaldehyde Suppliers

Amadis Chemical Company Limited
Gold Member
Audited Supplier Audited Supplier
(CAS:335196-05-9)2-chloro-8-ethylquinoline-3-carbaldehyde
Order Number:A1085508
Stock Status:in Stock
Quantity:1g/5g/10g
Purity:99%
Pricing Information Last Updated:Thursday, 29 August 2024 19:24
Price ($):317.0/957.0/1616.0

2-chloro-8-ethylquinoline-3-carbaldehyde Related Literature

Additional information on 2-chloro-8-ethylquinoline-3-carbaldehyde

2-Chloro-8-Ethylquinoline-3-Carbaldehyde: A Comprehensive Overview

2-Chloro-8-Ethylquinoline-3-Carbaldehyde, also known by its CAS number 335196-05-9, is a compound of significant interest in the fields of organic chemistry and pharmacology. This compound belongs to the quinoline family, which has long been recognized for its diverse applications in drug discovery, material science, and chemical synthesis. The structure of 2-Chloro-8-Ethylquinoline-3-Carbaldehyde features a quinoline ring system with a chlorine substituent at position 2, an ethyl group at position 8, and a carbonyl group (aldehyde) at position 3. These functional groups contribute to its unique chemical properties and reactivity.

The synthesis of 2-Chloro-8-Ethylquinoline-3-Carbaldehyde typically involves multi-step organic reactions, often starting from simpler precursors like o-chloroaniline or related aromatic compounds. Recent advancements in catalytic methods and green chemistry have enabled more efficient and environmentally friendly routes for its preparation. For instance, researchers have explored the use of transition metal catalysts to facilitate key steps such as alkylation and oxidation, thereby improving yield and purity.

One of the most promising applications of 2-Chloro-8-Ethylquinoline-3-Carbaldehyde lies in its potential as a building block for drug development. Quinoline derivatives are known for their ability to modulate various biological targets, including enzymes, receptors, and ion channels. Recent studies have demonstrated that this compound exhibits selective inhibitory activity against certain kinases involved in cancer cell proliferation. This finding has sparked interest in exploring its role as a lead compound for anti-cancer therapeutics.

In addition to its pharmacological applications, 2-Chloro-8-Ethylquinoline-3-Carbaldehyde has shown promise in materials science. Its conjugated π-system and functional groups make it a candidate for use in organic electronics, such as light-emitting diodes (LEDs) and photovoltaic devices. Researchers have investigated its ability to act as an electron transport layer or as a component in hybrid materials that enhance device performance.

The chemical stability of 2-Chloro-8-Ethylquinoline-3-Carbaldehyde under various conditions is another area of active research. Understanding its degradation pathways is crucial for optimizing its synthesis, storage, and application. Recent studies have employed computational chemistry techniques to predict the compound's reactivity under different pH levels and temperatures, providing valuable insights for practical use.

In conclusion, 2-Chloro-8-Ethylquinoline-3-Carbaldehyde, with its unique structure and versatile properties, continues to be a focal point in both academic research and industrial applications. As new synthetic methods emerge and its biological and material properties are further elucidated, this compound is expected to play an increasingly important role in advancing science and technology.

335196-05-9 (2-chloro-8-ethylquinoline-3-carbaldehyde) Related Products

Recommended suppliers
Amadis Chemical Company Limited
(CAS:335196-05-9)2-chloro-8-ethylquinoline-3-carbaldehyde
A1085508
Purity:99%/99%/99%
Quantity:1g/5g/10g
Price ($):317.0/957.0/1616.0
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