• 1. An integrated chip for immunofluorescence and its application to analyze lysosomal storage disorders
  Jie Shen,Ying Zhou,Tu Lu,Junya Peng,Zhixiang Lin,Yuhong Pang,Li Yu Lab Chip, 2012,12, 317-324
• 2. An anti-leakage liquid metal thermal interface material
  Kaiyuan Huang,Wangkang Qiu,Meilian Ou,Xiaorui Liu,Zenan Liao,Sheng Chu RSC Adv., 2020,10, 18824-18829
• 3. An amphoteric reactivity of a mixed-valent bis(μ-oxo)dimanganese(iii,iv) complex acting as an electrophile and a nucleophile?
  Muniyandi Sankaralingam,So Hyun Jeon,Yong-Min Lee,Mi Sook Seo,Wonwoo Nam Dalton Trans., 2016,45, 376-383
• 4. An ATP-selective, lanthanide complex luminescent probe?
  Xiao Liu,Jun Xu,Yinyun Lv,Wenyu Wu,Weisheng Liu,Yu Tang Dalton Trans., 2013,42, 9840-9846
• 5. An ionic liquid-based synergistic extraction strategy for rare earths?
  Yingbo Li,Nada Mehio,Huizhou Liu,Sheng Dai Green Chem., 2015,17, 2981-2993

2,6-Diamino-4-hydroxy-5-nitrosopyrimidine (CAS No. 3346-23-4)

2,6-Diamino-4-hydroxy-5-nitrosopyrimidine is a heterocyclic organic compound with the CAS registry number 3346-23-4. This compound belongs to the class of pyrimidines, which are six-membered aromatic rings containing two nitrogen atoms at positions 1 and 3. The structure of 2,6-diamino-4-hydroxy-5-nitrosopyrimidine is characterized by the presence of amino groups (-NH?) at positions 2 and 6, a hydroxyl group (-OH) at position 4, and a nitroso group (-N=O) at position 5. These functional groups contribute to its unique chemical properties and reactivity.

The synthesis of 2,6-diamino-4-hydroxy-5-nitrosopyrimidine involves various methods, including condensation reactions and nitrosation processes. Recent studies have explored the use of microwave-assisted synthesis to enhance reaction efficiency and yield. This approach has shown promise in producing high-purity samples of the compound for further applications.

One of the most significant applications of 2,6-diamino-4-hydroxy-5-nitrosopyrimidine is in the field of medicinal chemistry. The compound serves as an intermediate in the synthesis of various bioactive molecules, including potential drug candidates for treating diseases such as cancer and neurodegenerative disorders. For instance, researchers have investigated its role in the development of inhibitors for key enzymes involved in cell signaling pathways.

Recent advancements in computational chemistry have enabled detailed studies of the electronic structure and reactivity of 2,6-diamino-4-hydroxy-5-nitrosopyrimidine. Density functional theory (DFT) calculations have provided insights into the molecule's π-electron distribution and its ability to undergo redox reactions. These findings are crucial for understanding its behavior in biological systems and its potential as a pharmacophore.

In addition to its medicinal applications, 2,6-diamino-4-hydroxy-5-nitrosopyrimidine has been studied for its role in materials science. The compound exhibits interesting optical properties due to its conjugated π-system, making it a candidate for use in organic semiconductors and light-emitting diodes (LEDs). Recent experiments have demonstrated its potential as a building block for constructing novel materials with tailored electronic properties.

The stability and degradation pathways of 2,6-diamino-4-hydroxy-5-nitrosopyrimidine under various conditions have also been investigated. Studies have shown that the compound is relatively stable under neutral conditions but undergoes hydrolysis in acidic or basic environments. Understanding these degradation mechanisms is essential for ensuring the safety and shelf life of products containing this compound.

From an environmental perspective, researchers have assessed the biodegradability and toxicity of 2,6-diamino-4-hydroxy-5-nitrosopyrimidine. Results indicate that the compound has low acute toxicity but may pose risks to aquatic organisms under certain conditions. These findings highlight the need for responsible handling and disposal practices when working with this compound.

In conclusion, 2,6-diamino-4-hydroxy-5-nitrosopyrimidine (CAS No. 3346-23-4) is a versatile compound with applications spanning medicinal chemistry, materials science, and environmental studies. Its unique structure and functional groups make it a valuable building block for developing new compounds with diverse functionalities. Ongoing research continues to uncover new insights into its properties and potential uses, underscoring its importance in modern chemical research.

• 3137-55-1(4(3H)-Pyrimidinone,6-hydrazinyl-5-nitro-)
• 4214-85-1(2-amino-6-methyl-5-nitro-3,4-dihydropyrimidin-4-one)
• 801156-87-6(Acetaldehyde,2-[(2-amino-1,6-dihydro-1-methyl-5-nitro-6-oxo-4-pyrimidinyl)amino]-)
• 299916-90-8(Acetamide,N-(1,6-dihydro-4-methyl-5-nitro-6-oxo-2-pyrimidinyl)-)
• 880-89-7(4(3H)-Pyrimidinone,6-amino-2-(dimethylamino)-5-nitro-)
• 70700-44-6(2-Dimethylamino-4-hydroxy-5-nitroso-6-aminopyrimidine)
• 1004-75-7(2,5,6-triamino-1,4-dihydropyrimidin-4-one)
• 219543-69-8(4-Hydroxy-5-nitropyrimidine)
• 2387-48-6(2,6-Diamino-4-hydroxy-5-nitrosopyrimidine)
• 7254-29-7(2-Amino-5-nitropyrimidin-4(1H)-one)