Cas no 33282-15-4 (5-(4-hydroxyphenyl)-1,2-oxazole-3-carboxylic acid)

5-(4-Hydroxyphenyl)-1,2-oxazole-3-carboxylic acid is a heterocyclic compound featuring a 1,2-oxazole (isoxazole) core substituted with a carboxylic acid group at the 3-position and a 4-hydroxyphenyl moiety at the 5-position. This structure confers versatility in synthetic applications, particularly as an intermediate in pharmaceutical and agrochemical research. The presence of both hydroxyl and carboxylic acid functional groups enhances its reactivity, enabling further derivatization or coordination chemistry. Its rigid aromatic framework contributes to stability, while the polar substituents improve solubility in protic solvents. This compound is valued for its potential in designing biologically active molecules, including enzyme inhibitors or metal-chelating agents, due to its balanced electronic and steric properties.
5-(4-hydroxyphenyl)-1,2-oxazole-3-carboxylic acid structure
33282-15-4 structure
Product Name:5-(4-hydroxyphenyl)-1,2-oxazole-3-carboxylic acid
CAS No:33282-15-4
MF:C10H7NO4
MW:205.166882753372
MDL:MFCD05237205
CID:852236
PubChem ID:1090983
Update Time:2025-05-20

5-(4-hydroxyphenyl)-1,2-oxazole-3-carboxylic acid Chemical and Physical Properties

Names and Identifiers

    • 5-(4-Hydroxyphenyl)isoxazole-3-carboxylic acid
    • AKOS B022853
    • 5-(4-HYDROXY-PHENYL)-ISOXAZOLE-3-CARBOXYLIC ACID
    • ART-CHEM-BB B022853
    • TIMTEC-BB SBB007150
    • 5-(4-hydroxyphenyl)-1,2-oxazole-3-carboxylic acid
    • CS-0085268
    • 5-(4-hydroxyphenyl)isoxazole-3-carboxylicacid
    • 33282-15-4
    • PSQJYQJRWKEMEC-UHFFFAOYSA-N
    • 5-(4-hydroxyphenyl)-isoxazole-3-carboxylic acid
    • STK346753
    • SR-01000367140
    • Z1245633797
    • AKOS000266172
    • HMS2632B07
    • EN300-83742
    • CHEMBL1327656
    • SMR000277667
    • MLS000716150
    • 5-(4-hydroxy-phenyl)-isoxazole-3-carboxylic acid, AldrichCPR
    • SY015161
    • BBL010113
    • SR-01000367140-1
    • 5-(4-HYDROXYPHENYL)-3-ISOXAZOLECARBOXYLIC ACID
    • DA-18255
    • TimTec1_004694
    • HMS1547F08
    • F1984-0183
    • SCHEMBL72786
    • ALBB-007391
    • MFCD05237205
    • AS-31710
    • MDL: MFCD05237205
    • Inchi: 1S/C10H7NO4/c12-7-3-1-6(2-4-7)9-5-8(10(13)14)11-15-9/h1-5,12H,(H,13,14)
    • InChI Key: PSQJYQJRWKEMEC-UHFFFAOYSA-N
    • SMILES: O1C(=CC(C(=O)O)=N1)C1C=CC(=CC=1)O

Computed Properties

  • Exact Mass: 205.03800
  • Monoisotopic Mass: 205.03750770g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 15
  • Rotatable Bond Count: 2
  • Complexity: 238
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 1.6
  • Topological Polar Surface Area: 83.6?2

Experimental Properties

  • Boiling Point: 492.4±35.0℃ at 760 mmHg
  • PSA: 83.56000
  • LogP: 1.74540

5-(4-hydroxyphenyl)-1,2-oxazole-3-carboxylic acid Security Information

  • Hazardous Material Identification: Xi
  • HazardClass:IRRITANT

5-(4-hydroxyphenyl)-1,2-oxazole-3-carboxylic acid Customs Data

  • HS CODE:2934999090
  • Customs Data:

    China Customs Code:

    2934999090

    Overview:

    2934999090. Other heterocyclic compounds. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Additional information on 5-(4-hydroxyphenyl)-1,2-oxazole-3-carboxylic acid

Comprehensive Overview of 5-(4-hydroxyphenyl)-1,2-oxazole-3-carboxylic acid (CAS No. 33282-15-4)

5-(4-hydroxyphenyl)-1,2-oxazole-3-carboxylic acid, with the CAS number 33282-15-4, is a specialized organic compound that has garnered significant attention in pharmaceutical and biochemical research. This compound, characterized by its unique oxazole ring and hydroxyphenyl moiety, serves as a critical intermediate in the synthesis of various bioactive molecules. Its structural features make it a valuable candidate for drug discovery, particularly in the development of anti-inflammatory and antioxidant agents. Researchers are increasingly exploring its potential applications due to its molecular stability and bioavailability, which align with current trends in precision medicine and sustainable chemistry.

In recent years, the demand for heterocyclic compounds like 5-(4-hydroxyphenyl)-1,2-oxazole-3-carboxylic acid has surged, driven by their versatility in medicinal chemistry. The compound’s carboxylic acid group enables facile derivatization, allowing scientists to tailor its properties for specific therapeutic targets. This adaptability resonates with the growing focus on personalized medicine and green chemistry, where efficiency and environmental impact are paramount. Moreover, its hydroxyphenyl component contributes to its radical-scavenging activity, a feature highly sought after in the development of nutraceuticals and cosmeceuticals.

The synthesis and characterization of CAS 33282-15-4 have been extensively documented in peer-reviewed journals, highlighting its crystallographic properties and spectroscopic behavior. Advanced techniques such as NMR spectroscopy and X-ray diffraction have been employed to elucidate its molecular structure, ensuring reproducibility and quality control in industrial applications. These methodologies align with the broader scientific community’s emphasis on data-driven research and transparent reporting, which are critical for regulatory compliance and intellectual property protection.

From a commercial perspective, 5-(4-hydroxyphenyl)-1,2-oxazole-3-carboxylic acid is available through specialized chemical suppliers, catering to academic institutions and pharmaceutical companies. Its pricing and availability are influenced by factors such as purity grade and batch size, which are common considerations for procurement professionals. The compound’s shelf life and storage conditions are also frequently queried topics, reflecting the practical challenges of handling sensitive biochemicals. Suppliers often provide technical datasheets and safety guidelines to address these concerns, ensuring compliance with global standards like REACH and GMP.

In the context of drug development, 33282-15-4 has been investigated for its role in modulating enzymatic pathways, particularly those involved in oxidative stress and inflammation. Preclinical studies suggest its potential as a lead compound for treating chronic diseases, a topic of immense interest given the rising prevalence of conditions like diabetes and neurodegenerative disorders. These findings are often discussed in forums and conferences focused on translational research, where bridging the gap between lab discoveries and clinical applications is a key objective.

Environmental and safety profiles of 5-(4-hydroxyphenyl)-1,2-oxazole-3-carboxylic acid are another area of scrutiny, especially under the lens of sustainable chemistry. Regulatory bodies and industry stakeholders prioritize compounds with minimal ecological footprints, prompting manufacturers to adopt green synthesis routes. Lifecycle assessments and eco-toxicity studies are increasingly integrated into R&D workflows, ensuring that new chemicals meet both performance and sustainability criteria. This dual focus aligns with the United Nations’ Sustainable Development Goals (SDGs), particularly those related to responsible consumption and production.

Looking ahead, the trajectory of CAS 33282-15-4 appears promising, with ongoing research exploring its utility in nanotechnology and material science. Its ability to form stable complexes with metals and polymers opens doors to innovative applications, such as drug delivery systems and bio-sensors. These interdisciplinary opportunities reflect the compound’s adaptability, a trait highly valued in today’s fast-evolving scientific landscape. As the boundaries between chemistry, biology, and engineering blur, 5-(4-hydroxyphenyl)-1,2-oxazole-3-carboxylic acid stands poised to play a pivotal role in shaping future technologies.

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