• 1. Ester-directed orthogonal dual C–H activation and ortho aryl C–H alkenylation via distal weak coordination?
  Manickam Bakthadoss,Tadiparthi Thirupathi Reddy,Vishal Agarwal,Duddu S. Sharada Chem. Commun., 2022,58, 1406-1409
• 2. Emerging investigator series: heterogeneous reactions of sulfur dioxide on mineral dust nanoparticles: from single component to mixed components?
  Tao Wang,Yangyang Liu,Yue Deng,Hongbo Fu,Jianmin Chen Environ. Sci.: Nano, 2018,5, 1821-1833
• 3. Evolving better nanoparticles: Genetic algorithms for optimising cluster geometries
  Dalton Trans., 2003, 4193-4207
• 4. Excellent mechanical performance and enhanced dielectric properties of OBC/SiO2 elastomeric nanocomposites: effect of dispersion of the SiO2 nanoparticles?
  Xing Zhao,Lu Bai,Rui-Ying Bao,Zheng-Ying Liu,Ming-Bo Yang,Wei Yang RSC Adv., 2017,7, 46297-46305
• 5. Enabling chloride salts for thermal energy storage: implications of salt purity?
  J. Matthew Kurley,Phillip W. Halstenberg,Abbey McAlister,Stephen Raiman,Richard T. Mayes RSC Adv., 2019,9, 25602-25608

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Imidazopyrimidines 6-aminopurines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Imidazopyrimidines Purines and purine derivatives 6-aminopurines

Comprehensive Overview of 9H-Purine-9-butanoic acid, 6-amino- (CAS No. 33147-28-3): Properties, Applications, and Research Insights

9H-Purine-9-butanoic acid, 6-amino- (CAS No. 33147-28-3) is a specialized purine derivative with significant relevance in biochemical and pharmaceutical research. This compound, characterized by its purine backbone and butanoic acid side chain, has garnered attention for its potential applications in drug development, nucleotide synthesis, and enzymatic studies. Researchers and industry professionals frequently search for terms like "purine derivatives in medicine" or "6-amino purine applications", reflecting its growing importance in scientific communities.

The molecular structure of 9H-Purine-9-butanoic acid, 6-amino- includes a 6-amino group attached to the purine ring, which enhances its reactivity and binding affinity. This feature makes it a valuable intermediate in synthesizing modified nucleosides, a topic often queried as "nucleoside analog synthesis" in academic databases. Its butanoic acid moiety further expands its utility in conjugation reactions, particularly in bioconjugation techniques used for labeling biomolecules—a hotspot in current proteomics and diagnostics research.

Recent trends highlight the compound's role in cancer therapeutics and antiviral drug design, aligning with popular search queries such as "purine-based anticancer agents". Studies suggest that modifications of the 9H-Purine scaffold can modulate interactions with enzymes like kinases and polymerases, offering avenues for targeted therapies. Additionally, its use in fluorescence labeling (often searched as "purine fluorescent probes") has been explored for real-time cellular imaging, a technique pivotal in precision medicine.

From a synthetic chemistry perspective, CAS No. 33147-28-3 serves as a building block for heterocyclic compound libraries, a topic frequently discussed in high-throughput screening methodologies. Its stability under physiological conditions also makes it suitable for prodrug development, addressing search trends like "prodrug activation mechanisms". Furthermore, the compound's compatibility with click chemistry (a trending technique) enables rapid modular assembly of complex molecules.

Environmental and safety profiles of 9H-Purine-9-butanoic acid, 6-amino- are rigorously documented, ensuring compliance with green chemistry principles—a key concern for modern researchers. Analytical methods such as HPLC and LC-MS (common search terms) are routinely employed to validate its purity, underscoring its reliability for GMP-grade applications. As interest in personalized medicine grows, this compound's versatility positions it as a critical tool for advancing biomarker discovery and therapeutic innovation.

In summary, 9H-Purine-9-butanoic acid, 6-amino- (CAS No. 33147-28-3) bridges fundamental research and applied science, addressing contemporary needs in drug discovery and molecular diagnostics. Its multifaceted applications—from enzyme inhibition studies to bioconjugation strategies—reflect its alignment with cutting-edge scientific inquiries, making it a compound of enduring relevance in 21st-century research.

• 4244-47-7(6-amino-9H-Purine-9-propanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)