Cas no 33019-03-3 (2-Furancarboxylic acid,tetrahydro-5-oxo-, ethyl ester, (2R)-)

2-Furancarboxylic acid, tetrahydro-5-oxo-, ethyl ester, (2R)-, is a chiral ester derivative of tetrahydrofuran-2-carboxylic acid, featuring a stereospecific (R)-configuration at the 2-position. This compound is valued for its role as a versatile intermediate in organic synthesis, particularly in the preparation of pharmaceuticals, agrochemicals, and fine chemicals. Its well-defined stereochemistry ensures high enantioselectivity in asymmetric reactions, while the ester functionality enhances reactivity in nucleophilic substitution or reduction processes. The tetrahydrofuran ring contributes to structural stability and solubility in organic solvents, facilitating its use in complex synthetic routes. Its consistent purity and stereochemical integrity make it a reliable choice for research and industrial applications.
2-Furancarboxylic acid,tetrahydro-5-oxo-, ethyl ester, (2R)- structure
33019-03-3 structure
Product Name:2-Furancarboxylic acid,tetrahydro-5-oxo-, ethyl ester, (2R)-
CAS No:33019-03-3
MF:C7H10O4
MW:158.151902675629
CID:293992
PubChem ID:24861452
Update Time:2025-11-05

2-Furancarboxylic acid,tetrahydro-5-oxo-, ethyl ester, (2R)- Chemical and Physical Properties

Names and Identifiers

    • 2-Furancarboxylic acid,tetrahydro-5-oxo-, ethyl ester, (2R)-
    • (R)-(?)-γ-Ethoxycarbonyl-γ-butyrolactone
    • (2S)-tetrahydro-5-oxo-2-furancarboxylic acid ethyl ester
    • (R)-(-)-
    • (R)-(-)-γ-Ethoxycarbonyl-γ-butyrolactone
    • (S)-(+)-tetrahydro-5-oxo-2-furancarboxylic acid ethyl ester
    • 346969_ALDRICH
    • A-butyrolactone
    • AC1LGWUF
    • A-Ethoxycarbonyl-
    • Ethyl (R)-(-)-5-oxotetrahydro-2-furancarboxylate
    • ethyl (S)-(+)-tetrahydro-5-oxo-2-furancarboxylate
    • Ethyl (S)-5-oxotetrahydrofuran-2-carboxylate
    • I04-8473
    • MJQGWRVDIFBMNW-UHFFFAOYSA-
    • S-(+)-4-carbossietil-4-butanolide
    • SureCN5634387
    • Ethyl (R)-5-oxotetrahydrofuran-2-carboxylate
    • (R)-(-)-gamma-Ethoxycarbonyl-gamma-butyrolactone, 95%
    • DTXSID60357406
    • (R)-(-)-gamma-Ethoxycarbonyl-gamma-butyrolactone
    • J-018979
    • SCHEMBL5634387
    • (r)-(-)-ethyl tetrahydro-5-oxo-2-furancarboxylate
    • Ethyl(R)-5-oxotetrahydrofuran-2-carboxylate
    • 33019-03-3
    • (R)-(-)- gamma -Ethoxycarbonyl- gamma -butyrolactone
    • ethyl (2R)-5-oxooxolane-2-carboxylate
    • G64450
    • MDL： MFCD00075372
    • Inchi： 1S/C7H10O4/c1-2-10-7(9)5-3-4-6(8)11-5/h5H,2-4H2,1H3/t5-/m1/s1
    • InChI Key： MJQGWRVDIFBMNW-RXMQYKEDSA-N
    • SMILES： O1C(CC[C@@H]1C(=O)OCC)=O

Computed Properties

  • Exact Mass: 158.0579
  • Monoisotopic Mass: 158.05790880g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 11
  • Rotatable Bond Count: 3
  • Complexity: 175
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 1
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: 2
  • XLogP3: 0.5
  • Topological Polar Surface Area: 52.6?2

Experimental Properties

  • Color/Form: colorless liquid
  • Density: 1.163?g/mL?at 25?°C(lit.)
  • Boiling Point: 151-155?°C/12?mmHg(lit.)
  • Flash Point: Degrees Fahrenheit:230°F
    Degrees Celsius:110°C
  • Refractive Index: n20/D 1.448(lit.)
  • PSA: 52.6
  • LogP: 0.25510
  • Solubility: Not determined
  • Optical Activity: [α]20/D ?12°, c =?0.4 in ethanol

2-Furancarboxylic acid,tetrahydro-5-oxo-, ethyl ester, (2R)- Security Information

  • Hazardous Material transportation number：NONH for all modes of transport
  • WGK Germany：3
  • Safety Instruction： 23-24/25

2-Furancarboxylic acid,tetrahydro-5-oxo-, ethyl ester, (2R)- Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd.
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2-Furancarboxylic acid,tetrahydro-5-oxo-, ethyl ester, (2R)-
 33019-03-3 95%
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 ￥738.0 2024-07-18
XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd.
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2-Furancarboxylic acid,tetrahydro-5-oxo-, ethyl ester, (2R)- Related Literature

Related Categories

Additional information on 2-Furancarboxylic acid,tetrahydro-5-oxo-, ethyl ester, (2R)-

Comprehensive Guide to 2-Furancarboxylic acid, tetrahydro-5-oxo-, ethyl ester, (2R)- (CAS No. 33019-03-3)

2-Furancarboxylic acid, tetrahydro-5-oxo-, ethyl ester, (2R)- (CAS No. 33019-03-3) is a specialized organic compound with significant applications in pharmaceuticals, agrochemicals, and fine chemical synthesis. This ester derivative of tetrahydrofuran is known for its chiral properties, making it valuable in asymmetric synthesis and enantioselective reactions. Researchers and industries are increasingly interested in this compound due to its role in developing bioactive molecules and sustainable chemical processes.

The compound’s structure features a tetrahydrofuran ring with a 5-oxo (ketone) group and an ethyl ester moiety at the (2R) position. This configuration enhances its reactivity and selectivity in synthetic pathways. With the growing demand for chiral intermediates in drug development, 2-Furancarboxylic acid, tetrahydro-5-oxo-, ethyl ester, (2R)- has gained attention for its potential in creating optically active pharmaceuticals.

One of the key applications of CAS 33019-03-3 is in the synthesis of flavor and fragrance compounds. The compound’s unique structure contributes to the production of esters and lactones used in food additives and perfumery. Additionally, its role in green chemistry aligns with current trends toward sustainable and eco-friendly synthesis methods. Researchers are exploring its use in biocatalysis and enzymatic transformations to reduce environmental impact.

In the pharmaceutical sector, (2R)-2-Furancarboxylic acid tetrahydro-5-oxo- ethyl ester serves as a building block for antiviral and anti-inflammatory agents. Its chiral center is critical for designing drugs with higher efficacy and fewer side effects. Recent studies highlight its potential in developing protease inhibitors and other targeted therapies, addressing global health challenges such as infectious diseases and chronic conditions.

The agrochemical industry also benefits from this compound, particularly in formulating pesticides and herbicides with improved selectivity. Its incorporation into active ingredients enhances crop protection while minimizing ecological harm. As regulatory pressures push for safer agrochemicals, 2-Furancarboxylic acid derivatives are becoming a focus for innovation.

From a market perspective, the demand for CAS No. 33019-03-3 is rising due to its versatility and alignment with industry trends. Manufacturers are investing in scalable synthesis methods to meet the needs of pharmaceuticals, flavors, and agrochemicals. Analytical techniques like HPLC and NMR ensure high purity, which is essential for end-use applications.

For researchers and procurement specialists, sourcing high-quality 2-Furancarboxylic acid, tetrahydro-5-oxo-, ethyl ester, (2R)- is crucial. Reputable suppliers provide detailed technical data sheets, including spectroscopic data and safety information. Storage recommendations typically include cool, dry conditions to maintain stability.

In summary, 2-Furancarboxylic acid, tetrahydro-5-oxo-, ethyl ester, (2R)- (CAS 33019-03-3) is a multifaceted compound with expanding applications. Its chiral properties, synthetic utility, and role in sustainable chemistry make it a valuable asset across industries. As research advances, its potential in drug discovery, green chemistry, and agrochemicals will continue to grow.

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