Cas no 329939-43-7 (4-Bromo-N-(4-methoxybenzyl)benzenesulfonamide)

4-Bromo-N-(4-methoxybenzyl)benzenesulfonamide is a sulfonamide derivative featuring a brominated benzene ring and a 4-methoxybenzyl substituent. This compound is of interest in synthetic organic chemistry, particularly in the development of pharmacologically active molecules or as an intermediate in medicinal chemistry research. The bromine moiety offers a reactive site for further functionalization via cross-coupling reactions, while the methoxybenzyl group may influence solubility and electronic properties. Its well-defined structure makes it suitable for structure-activity relationship (SAR) studies or as a building block in the synthesis of more complex sulfonamide-based compounds. Careful handling is advised due to potential reactivity under certain conditions.

4-Bromo-N-(4-methoxybenzyl)benzenesulfonamide structure

329939-43-7 structure

Product Name:4-Bromo-N-(4-methoxybenzyl)benzenesulfonamide

CAS No:329939-43-7

MF:C₁₄H₁₄BrNO₃S

MW:356.234861850739

MDL:MFCD01359619

CID:301705

PubChem ID:986643

Update Time:2025-08-04

4-Bromo-N-(4-methoxybenzyl)benzenesulfonamide Chemical and Physical Properties

Names and Identifiers

- 4-Bromo-N-(4-methoxybenzyl)benzenesulfonamide
- 4-bromo-N-[(4-methoxyphenyl)methyl]benzenesulfonamide
- Benzenesulfonamide,4-bromo-N-[(4-methoxyphenyl)methyl]-
- N-(4-Methoxybenzyl) 4-bromobenzenesulfonamide
- 4-Bromo-N-(4-methoxybenzyl)benzenesulphonamide
- AC1LK7SE
- ACMC-1AH5S
- CBMicro_027143
- CTK4G9684
- SureCN3914871
- F71930
- AKOS000383622
- DTXSID20359704
- BIM-0027073.P001
- CS-0206529
- AN-652/12072713
- MFCD01359619
- 4-Bromo-N-[(4-methoxyphenyl)methyl]benzene-1-sulfonamide
- BS-28056
- Z45535444
- 329939-43-7
- SCHEMBL3914871
- STK033126
- DB-412451
- MDL： MFCD01359619
- Inchi： 1S/C14H14BrNO3S/c1-19-13-6-2-11(3-7-13)10-16-20(17,18)14-8-4-12(15)5-9-14/h2-9,16H,10H2,1H3
- InChI Key： HKTIXZGUJGCYDO-UHFFFAOYSA-N
- SMILES： BrC1C=CC(=CC=1)S(NCC1C=CC(=CC=1)OC)(=O)=O

Computed Properties

Exact Mass: 354.98800
Monoisotopic Mass: 354.98778g/mol
Isotope Atom Count: 0
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 4
Heavy Atom Count: 20
Rotatable Bond Count: 5
Complexity: 380
Covalently-Bonded Unit Count: 1
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count : 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
XLogP3: 3
Topological Polar Surface Area: 63.8?2

Experimental Properties

Density: 1.478
Boiling Point: 481.4°Cat760mmHg
Flash Point: 244.9°C
Refractive Index: 1.602
PSA: 63.78000
LogP: 4.40790

4-Bromo-N-(4-methoxybenzyl)benzenesulfonamide Security Information

Signal Word：warning
Hazard Statement： H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
Warning Statement： P264+P280+P305+P351+P338+P337+P313
Safety Instruction： H303+H313+H333
Hazardous Material Identification：
Storage Condition：storage at -4℃ (1-2weeks), longer storage period at -20℃ (1-2years)

4-Bromo-N-(4-methoxybenzyl)benzenesulfonamide Customs Data

HS CODE：2935009090
Customs Data：

China Customs Code:
2935009090

Overview:

2935009090 Other sulphonates(Acyl)amine. VAT:17.0% Tax refund rate:9.0% Regulatory conditions:nothing MFN tariff:6.5% general tariff:35.0%

Declaration elements:

Product Name, component content, use to

Summary:

2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

4-Bromo-N-(4-methoxybenzyl)benzenesulfonamide Pricemore >>

Related Categories	No.	Product Name	Cas No.	Purity	Specification	Price	update time
Fluorochem	213629-1g	4-Bromo-N-(4-methoxybenzyl)benzenesulfonamide	329939-43-7	95%	1g	￡113.00	2022-03-01
Fluorochem	213629-5g	4-Bromo-N-(4-methoxybenzyl)benzenesulfonamide	329939-43-7	95%	5g	￡338.00	2022-03-01
TRC	B686483-10mg	4-Bromo-n-(4-methoxybenzyl)benzenesulfonamide	329939-43-7		10mg	$ 50.00	2022-06-06
TRC	B686483-50mg	4-Bromo-n-(4-methoxybenzyl)benzenesulfonamide	329939-43-7		50mg	$ 65.00	2022-06-06
TRC	B686483-100mg	4-Bromo-n-(4-methoxybenzyl)benzenesulfonamide	329939-43-7		100mg	$ 80.00	2022-06-06
Alichem	A019089000-10g	4-Bromo-N-(4-methoxybenzyl)benzenesulfonamide	329939-43-7	95%	10g	$437.58	2023-09-02
Apollo Scientific	OR59350-1g	4-Bromo-N-(4-methoxybenzyl)benzenesulphonamide	329939-43-7		1g	￡145.00	2025-02-20
eNovation Chemicals LLC	Y1247809-1g	4-Bromo-N-(4-methoxybenzyl)benzenesulfonamide	329939-43-7	98%	1g	$140	2024-06-06
eNovation Chemicals LLC	Y1247809-5g	4-Bromo-N-(4-methoxybenzyl)benzenesulfonamide	329939-43-7	98%	5g	$285	2024-06-06
abcr	AB246862-1 g	4-Bromo-N-(4-methoxybenzyl)benzenesulphonamide; .	329939-43-7		1g	€195.00	2023-06-22

4-Bromo-N-(4-methoxybenzyl)benzenesulfonamide Suppliers

Amadis Chemical Company Limited

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Audited Supplier

(CAS:329939-43-7)4-Bromo-N-(4-methoxybenzyl)benzenesulfonamide

Order Number:A875460

Stock Status:in Stock

Quantity:5g

Purity:99%

Pricing Information Last Updated:Friday, 30 August 2024 09:46

Price ($):261.0

Email:[email protected]

Product Official Link

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Related Categories

Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzenesulfonamides

Additional information on 4-Bromo-N-(4-methoxybenzyl)benzenesulfonamide

Professional Introduction to 4-Bromo-N-(4-methoxybenzyl)benzenesulfonamide (CAS No: 329939-43-7)

4-Bromo-N-(4-methoxybenzyl)benzenesulfonamide, identified by the Chemical Abstracts Service Number (CAS No) 329939-43-7, is a specialized organic compound that has garnered significant attention in the field of pharmaceutical chemistry and medicinal biology. This compound belongs to the class of sulfonamides, which are well-documented for their diverse biological activities and utility in drug development. The structural features of 4-Bromo-N-(4-methoxybenzyl)benzenesulfonamide, particularly the presence of a bromine substituent and a methoxybenzyl group, contribute to its unique chemical properties and potential applications in synthetic chemistry and biological assays.

The sulfonamide moiety in 4-Bromo-N-(4-methoxybenzyl)benzenesulfonamide is a key pharmacophore that interacts with biological targets, often leading to inhibitory effects on enzymes and receptors. This makes the compound a promising candidate for further investigation in the development of novel therapeutic agents. The bromine atom at the para position relative to the sulfonamide group enhances electrophilicity, making it susceptible to various chemical transformations that can be exploited in medicinal chemistry campaigns.

Recent advancements in computational chemistry and molecular modeling have facilitated a deeper understanding of the interactions between 4-Bromo-N-(4-methoxybenzyl)benzenesulfonamide and biological targets. These studies have highlighted its potential as an inhibitor of certain kinases and enzymes implicated in inflammatory and oncological pathways. The methoxybenzyl group not only influences the electronic properties of the molecule but also contributes to its solubility and metabolic stability, which are critical factors in drug design.

In vitro studies have demonstrated that 4-Bromo-N-(4-methoxybenzyl)benzenesulfonamide exhibits moderate activity against several cancer cell lines, suggesting its potential as an anticancer agent. The bromine substituent has been shown to enhance binding affinity to target proteins, potentially leading to more potent pharmacological effects. Additionally, the compound's structural flexibility allows for modifications that could optimize its pharmacokinetic profile, making it a versatile scaffold for drug discovery.

The synthesis of 4-Bromo-N-(4-methoxybenzyl)benzenesulfonamide involves multi-step organic reactions, including bromination, sulfonylation, and alkylation. Advanced synthetic methodologies have been employed to improve yield and purity, ensuring that the final product meets pharmaceutical standards. The use of catalytic systems has further refined these processes, reducing waste and enhancing efficiency.

One of the most intriguing aspects of 4-Bromo-N-(4-methoxybenzyl)benzenesulfonamide is its potential role in modulating immune responses. Preclinical research has indicated that sulfonamides can interact with immune receptors, influencing inflammatory pathways. This has opened up avenues for exploring its therapeutic applications in autoimmune diseases and chronic inflammation. The combination of structural features such as the bromine atom and methoxy group makes it an attractive candidate for further exploration in immunomodulatory therapies.

The growing interest in 4-Bromo-N-(4-methoxybenzyl)benzenesulfonamide has led to several ongoing clinical trials investigating its efficacy in treating various conditions. These trials aim to validate its biological activity and establish safe dosing regimens. The results from these studies are expected to provide valuable insights into its therapeutic potential and guide future drug development efforts.

From a regulatory perspective, ensuring compliance with Good Manufacturing Practices (GMP) is essential for the production of 4-Bromo-N-(4-methoxybenzyl)benzenesulfonamide. Quality control measures must be rigorously implemented to guarantee consistency and purity throughout the manufacturing process. This includes spectroscopic analysis, chromatographic techniques, and other analytical methods that confirm the identity and integrity of the compound.

The future prospects for 4-Bromo-N-(4-methoxybenzyl)benzenesulfonamide are promising, with ongoing research focusing on optimizing its pharmacological properties through structure-activity relationship (SAR) studies. By fine-tuning its chemical structure, scientists aim to enhance its potency, selectivity, and bioavailability. Collaborative efforts between academic institutions and pharmaceutical companies are likely to accelerate these developments, bringing new therapeutic options closer to reality.

In conclusion, 4-Bromo-N-(4-methoxybenzyl)benzenesulfonamide (CAS No: 329939-43-7) represents a significant advancement in pharmaceutical chemistry with broad applications in drug discovery and development. Its unique structural features make it a versatile tool for medicinal biologists seeking novel therapeutic agents. As research continues to uncover its potential benefits, 4-Bromo-N-( 4 -methoxybezyl ) benzen esul fon am ide is poised to play a crucial role in addressing various medical challenges.

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