• 1. Flexibility in metal–organic frameworks derived from positional and electronic effects of functional groups
  Hyeonbin Ha,Hyungwoo Hahm,Dong Gyun Jwa,Kwangho Yoo,Myung Hwan Park,Minyoung Yoon,Youngjo Kim,Min Kim CrystEngComm 2017 19 5361

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Phthalic acid and derivatives

1,4-Dimethyl 2,5-dichlorobenzene-1,4-dicarboxylate (CAS No. 3293-89-8): An Overview

1,4-Dimethyl 2,5-dichlorobenzene-1,4-dicarboxylate (CAS No. 3293-89-8) is a versatile organic compound with a unique molecular structure that has garnered significant attention in the fields of chemistry and pharmaceutical research. This compound is characterized by its aromatic core, substituted with two methyl groups and two chlorine atoms, along with two carboxylate groups. The combination of these functional groups imparts distinct chemical properties and reactivity, making it a valuable intermediate in the synthesis of various pharmaceuticals and materials.

The molecular formula of 1,4-dimethyl 2,5-dichlorobenzene-1,4-dicarboxylate is C₁₀H₈Cl₂O₄, and its molecular weight is approximately 267.07 g/mol. The compound exists as a white crystalline solid at room temperature and is soluble in common organic solvents such as dichloromethane, ethyl acetate, and dimethylformamide. Its melting point ranges from 135 to 137°C, which is an important physical property for its handling and storage.

In recent years, the study of 1,4-dimethyl 2,5-dichlorobenzene-1,4-dicarboxylate has expanded beyond its use as a synthetic intermediate. Researchers have explored its potential applications in the development of new materials and pharmaceuticals. For instance, a study published in the Journal of Organic Chemistry in 2022 highlighted the compound's role in the synthesis of novel polymers with enhanced thermal stability and mechanical strength. These polymers have shown promise in applications such as coatings, adhesives, and electronic materials.

The reactivity of 1,4-dimethyl 2,5-dichlorobenzene-1,4-dicarboxylate has also been a subject of interest in pharmaceutical research. The presence of carboxylate groups allows for the formation of ester linkages with various alcohols, which can be used to create prodrugs with improved pharmacokinetic properties. A recent study in the Bioorganic & Medicinal Chemistry Letters demonstrated that derivatives of this compound exhibited enhanced solubility and bioavailability when compared to their parent compounds. This finding has significant implications for drug delivery systems and the development of more effective therapeutic agents.

Beyond its synthetic utility, 1,4-dimethyl 2,5-dichlorobenzene-1,4-dicarboxylate has been investigated for its potential biological activities. Preliminary studies have shown that certain derivatives exhibit antimicrobial properties against a range of bacterial strains. These findings suggest that further research could lead to the development of new antibiotics or antifungal agents. Additionally, the compound's ability to form stable complexes with metal ions has been explored for potential applications in catalysis and materials science.

The environmental impact of 1,4-dimethyl 2,5-dichlorobenzene-1,4-dicarboxylate is another area of ongoing research. While it is not classified as a hazardous substance under current regulations, understanding its behavior in environmental systems is crucial for ensuring its safe use and disposal. Studies have shown that the compound can be biodegraded under certain conditions, but more research is needed to fully understand its fate and effects in natural environments.

In conclusion, 1,4-dimethyl 2,5-dichlorobenzene-1,4-dicarboxylate (CAS No. 3293-89-8) is a multifaceted compound with a wide range of applications in chemistry and pharmaceutical research. Its unique molecular structure provides a foundation for the development of new materials and therapeutic agents. As research continues to uncover new properties and applications, this compound is likely to remain an important player in the scientific community.

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