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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenylpropanes
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

Comprehensive Overview of 4-tert-Butylphenylacetic Acid (CAS No. 32857-63-9): Properties, Applications, and Industry Insights

4-tert-Butylphenylacetic Acid (CAS No. 32857-63-9) is a versatile organic compound widely utilized in pharmaceutical, cosmetic, and specialty chemical industries. This white crystalline powder, with a molecular formula of C₁₂H₁₆O₂, is recognized for its unique structural features, including a tert-butyl group and a phenylacetic acid moiety. Its balanced lipophilicity and acidity make it valuable for synthesizing esters, amides, and other derivatives with tailored properties.

Recent trends highlight growing interest in 4-tert-Butylphenylacetic Acid uses as a precursor in fragrance formulations and skin-care actives, aligning with the "clean beauty" movement. Researchers are exploring its potential in sustainable synthesis methods, responding to Google searches like "eco-friendly aromatic acid production." The compound’s CAS 32857-63-9 solubility in organic solvents (e.g., ethanol, DMSO) and mild water insolubility are frequently queried, underscoring its formulation flexibility.

From a technical perspective, 4-tert-Butylphenylacetic Acid exhibits a melting point range of 105–108°C and a molecular weight of 192.26 g/mol. Its carboxylic acid functionality enables reactions such as esterification, while the tert-butyl substituent enhances steric stability—a feature often discussed in forums on "bulky group effects in organic synthesis." Analytical techniques like HPLC and GC-MS are commonly employed for purity verification (>98%), addressing quality concerns in pharmaceutical intermediates manufacturing.

The compound’s role in non-steroidal anti-inflammatory drug (NSAID) research has gained attention, with patent filings referencing its derivatives for targeted therapies. This aligns with PubMed-indexed studies on "phenylacetic acid anti-inflammatory mechanisms." Additionally, its application in liquid crystal materials and polymer additives caters to material science innovations, frequently searched alongside terms like "high-performance aromatic compounds."

Regulatory compliance is another hotspot, as evidenced by searches for "4-tert-Butylphenylacetic Acid safety data." The compound is generally classified as non-hazardous under standard handling conditions, though proper PPE (gloves, goggles) is recommended during laboratory use. Its REACH registration status and FDA compliance for specific applications are critical considerations for industrial buyers.

Market analysts note rising demand for CAS 32857-63-9 suppliers in Asia-Pacific regions, driven by expanding cosmeceutical and agrochemical sectors. Technical bulletins emphasize batch-to-batch consistency, with advanced purification methods like recrystallization ensuring compliance with USP/EP standards. Storage recommendations (20–25°C in airtight containers) and shelf life optimization strategies are also prominent in procurement discussions.

Innovative applications continue to emerge, such as its incorporation into bio-based plasticizers and UV-stabilizing coatings—topics trending in sustainable chemistry circles. The compound’s structure-activity relationship (SAR) in medicinal chemistry remains a focus, particularly in computer-aided drug design (CADD) studies leveraging its modular scaffold.

For researchers investigating phenylacetic acid derivatives, this compound serves as a benchmark for studying electronic effects and steric hindrance in aromatic systems. Its NMR spectral data (characteristic peaks at 7.2–7.4 ppm for aromatic protons) and FT-IR signatures (1700 cm^-1 C=O stretch) are well-documented in spectral databases, facilitating structural confirmation.

Environmental fate studies indicate 4-tert-Butylphenylacetic Acid undergoes biodegradation via microbial pathways, with recent publications exploring its metabolic breakdown in soil systems. These findings support its inclusion in green chemistry workflows, particularly when compared to halogenated analogs.

In summary, 4-tert-Butylphenylacetic Acid (CAS No. 32857-63-9) represents a multifaceted building block bridging academic research and industrial applications. Its evolving applications—from fragrance fixatives to advanced material science—position it as a compound of enduring relevance in synthetic organic chemistry.

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• 172824-87-2((2S)-2-[4-(2-Methyl-2-propanyl)phenyl]propanoic acid)
• 20430-18-6(2-methyl-2-(4-methylphenyl)propanoic acid)
• 1247119-83-0(2-(4-ethylphenyl)-2-methyl-propanoic acid)
• 4476-28-2(4-Isopropylphenylacetic acid)
• 27749-40-2(Benzeneacetic acid,2-(1,1-dimethylethyl)-)
• 57438-45-6(2-methyl-2-4-(propan-2-yl)phenylpropanoic acid)
• 61776-69-0(Benzeneacetic acid, 4-(1-methylethyl)-, potassium salt (9CI))
• 552301-45-8(2-(4-(2-hydroxyethyl)phenyl)-2-Methylpropanoic acid)
• 826-55-1(2-methyl-2-phenylpropanoic acid)