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• 2. Excellent energy storage performance in NaNbO3-based relaxor antiferroeic ceramics under a low electric field
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• 3. Establishing empirical design rules of nucleic acid templates for the synthesis of silver nanoclusters with tunable photoluminescence and functionalities towards targeted bioimaging applications?
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzenesulfonamides

Comprehensive Overview of 3-(Piperidine-1-sulfonyl)benzohydrazide (CAS No. 328028-20-2): Properties, Applications, and Research Insights

3-(Piperidine-1-sulfonyl)benzohydrazide (CAS No. 328028-20-2) is a specialized organic compound that has garnered significant attention in pharmaceutical and chemical research due to its unique structural features and potential applications. This sulfonyl hydrazide derivative combines a piperidine ring with a benzohydrazide moiety, offering versatile reactivity and functional properties. Researchers are increasingly exploring its role in drug discovery, particularly as a scaffold for kinase inhibitors and enzyme modulators, aligning with current trends in targeted therapy development.

The compound's molecular structure (C₁₂H₁₇N₃O₃S) features a sulfonamide linkage (–SO₂–NH–) that enhances its stability and binding affinity, making it valuable for medicinal chemistry applications. Recent studies highlight its potential in addressing neurodegenerative diseases and metabolic disorders, topics frequently searched in academic databases. Its hydrogen-bonding capacity and lipophilic balance also make it a candidate for optimizing blood-brain barrier permeability, a key challenge in CNS drug development.

From a synthetic perspective, 3-(Piperidine-1-sulfonyl)benzohydrazide serves as an intermediate in multicomponent reactions, particularly in click chemistry and catalyzed cross-coupling processes. Industry professionals often search for "piperidine sulfonamide synthesis" or "benzohydrazide derivatives," reflecting growing interest in its preparative methods. Analytical techniques like HPLC-MS and NMR spectroscopy are essential for characterizing this compound, ensuring purity for research use.

Environmental and safety profiles of 328028-20-2 comply with standard laboratory handling protocols, though proper PPE (personal protective equipment) is recommended during manipulation. Its thermal stability (decomposition >200°C) and solubility profile (moderate in polar aprotic solvents) are frequently documented in chemical databases, addressing common queries from synthetic chemists.

Emerging applications include its use in proteolysis-targeting chimeras (PROTACs) and covalent inhibitor design, areas dominating recent PubMed searches. The piperidine-sulfonyl group's conformational flexibility allows for 3D pharmacophore modeling, a technique gaining traction in AI-driven drug discovery. These aspects position the compound as relevant to cutting-edge precision medicine initiatives.

Market analysts note rising demand for high-purity 328028-20-2 from contract research organizations (CROs), with suppliers emphasizing QC-certified batches. Regulatory documentation typically includes COA (Certificate of Analysis) and MSDS details, addressing compliance requirements for global research collaborations.

Future research directions may explore its metal-chelating properties for catalytic applications or its potential in bioconjugation techniques. The compound's structure-activity relationships (SAR) remain an active area of investigation, particularly in optimizing selectivity profiles for therapeutic targets. These developments align with industry searches for "next-generation pharmaceutical intermediates" and "fragment-based drug design."

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