Cas no 3235-04-9 (4-Methoxy-benzaldehyde oxime)

4-Methoxy-benzaldehyde oxime is an organic compound derived from the condensation of 4-methoxybenzaldehyde with hydroxylamine. This oxime derivative is characterized by its methoxy-substituted aromatic ring, which influences its reactivity and stability. It serves as a versatile intermediate in organic synthesis, particularly in the preparation of pharmaceuticals, agrochemicals, and fine chemicals. The presence of the oxime functional group allows for further transformations, such as reduction to amines or cyclization to heterocyclic compounds. Its well-defined structure and purity make it suitable for research and industrial applications requiring precise chemical modifications. The compound is typically handled under controlled conditions due to its sensitivity to moisture and heat.
4-Methoxy-benzaldehyde oxime structure
4-Methoxy-benzaldehyde oxime structure
Product Name:4-Methoxy-benzaldehyde oxime
CAS No:3235-04-9
MF:C8H9NO2
MW:151.162562131882
CID:310846
PubChem ID:5371961
Update Time:2025-10-10

4-Methoxy-benzaldehyde oxime Chemical and Physical Properties

Names and Identifiers

    • Benzaldehyde,4-methoxy-, oxime
    • 4-METHOXYBENZALDEHYDE OXIME
    • 4-Methoxy-benzaldehyde oxime
    • 4-Methoxy-benzaldoxim
    • 4-Methoxybenzaldoxime
    • Anisaldoxime
    • p-Anisaldehyde, oxime
    • p-Methoxybenzaldehyde oxime
    • p-Methoxybenzaldoxime
    • anti-p-Anisaldoxime
    • p-Anisaldehyde, (Z)-
    • NSC136032
    • p-Methoxy-anti-benzaldoxime
    • EINECS 221-788-4
    • N-[(4-methoxyphenyl)methylidene]hydroxylamine
    • MFCD00137433
    • AB01318939-02
    • NSC-44
    • (NZ)-N-[(4-methoxyphenyl)methylidene]hydroxylamine
    • 4-Methoxy-benzaldoxime
    • (NE)-N-[(4-methoxyphenyl)methylidene]hydroxylamine
    • AMY25143
    • 3235-04-9
    • p-Anisaldehyde, oxime, (E)-
    • NSC44
    • (1E)-4-methoxybenzaldehyde oxime
    • (E)-4-Methoxybenzaldehydeoxime
    • NSC-136032
    • syn-p-Anisaldoxime
    • Benzaldehyde, 4-methoxy-, oxime
    • A913902
    • p-Methoxy-syn-benzaldoxime
    • Z49568452
    • (Z)-4-Methoxybenzaldehyde oxime
    • AS-45340
    • NSC 44
    • 3717-22-4
    • Benzaldehyde, 4-methoxy-, oxime, (E)-
    • EN300-06090
    • 3717-21-3
    • SCHEMBL1566907
    • NSC-136033
    • p-Anisaldehyde oxime
    • p-Anisaldehyde, (E)-
    • AKOS000503115
    • CS-0307739
    • DTXSID901303874
    • AI3-19028
    • CHEMBL172979
    • (E)-4-Methoxybenzaldehyde oxime
    • NCGC00323540-01
    • NSC136033
    • FXOSHPAYNZBSFO-RMKNXTFCSA-N
    • CS-0369380
    • SCHEMBL8695977
    • DTXSID80954133
    • FXOSHPAYNZBSFO-UHFFFAOYSA-N
    • AKOS017263894
    • 4 -methoxybenzaldoxime
    • AR2369
    • ALBB-023277
    • DTXSID701295986
    • [C(Z)]-4-Methoxybenzaldehyde oxime
    • (E)-N-hydroxy-1-(4-methoxyphenyl)methanimine
    • STL069572
    • MDL: MFCD00137433
    • Inchi: 1S/C8H9NO2/c1-11-8-4-2-7(3-5-8)6-9-10/h2-6,10H,1H3/b9-6+
    • InChI Key: FXOSHPAYNZBSFO-RMKNXTFCSA-N
    • SMILES: O(C)C1C=CC(/C=N/O)=CC=1

Computed Properties

  • Exact Mass: 151.06337
  • Monoisotopic Mass: 151.063
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 1
  • Heavy Atom Count: 11
  • Rotatable Bond Count: 2
  • Complexity: 128
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 1
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 2
  • Topological Polar Surface Area: 41.8A^2

Experimental Properties

  • Density: 1.07g/cm3
  • Boiling Point: 247.4oC at 760mmHg
  • Flash Point: 103.4oC
  • Refractive Index: 1.51
  • PSA: 41.82
  • LogP: 1.50330

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4-Methoxy-benzaldehyde oxime Related Literature

Additional information on 4-Methoxy-benzaldehyde oxime

4-Methoxy-benzaldehyde oxime (CAS No. 3235-04-9): A Comprehensive Overview

4-Methoxy-benzaldehyde oxime (CAS No. 3235-04-9) is a versatile organic compound with a wide range of applications in the fields of chemistry, pharmaceuticals, and materials science. This compound, also known as p-methoxybenzaldoxime, is characterized by its unique molecular structure, which includes a methoxy group and an oxime functional group. These features contribute to its chemical reactivity and potential utility in various synthetic processes.

The molecular formula of 4-Methoxy-benzaldehyde oxime is C8H10N2O2, and its molecular weight is approximately 162.17 g/mol. The compound is a white crystalline solid at room temperature and is soluble in common organic solvents such as ethanol, methanol, and acetone. Its melting point ranges from 117 to 119°C, making it suitable for various thermal processes.

In the realm of organic synthesis, 4-Methoxy-benzaldehyde oxime serves as an important intermediate in the preparation of more complex molecules. Its reactivity with various electrophiles and nucleophiles allows for the formation of diverse functional groups, which can be further modified to create a wide array of compounds. Recent studies have highlighted its use in the synthesis of heterocyclic compounds, which are crucial in the development of new pharmaceuticals and materials.

P-methoxybenzaldoxime has gained significant attention in the pharmaceutical industry due to its potential as a building block for drug discovery. Researchers have explored its role in the synthesis of bioactive molecules, particularly those with anti-inflammatory, antimicrobial, and anticancer properties. For instance, a study published in the Journal of Medicinal Chemistry demonstrated that derivatives of 4-Methoxy-benzaldehyde oxime exhibit potent inhibitory activity against specific enzymes involved in cancer cell proliferation.

Beyond its applications in drug discovery, 4-Methoxy-benzaldehyde oxime has also found use in materials science. Its ability to form stable coordination complexes with metal ions makes it valuable in the development of metal-organic frameworks (MOFs) and other advanced materials. These materials have applications in gas storage, catalysis, and sensing technologies. A recent study published in the journal Advanced Materials highlighted the use of p-methoxybenzaldoxime-based MOFs for efficient gas separation and storage.

The environmental impact of 4-Methoxy-benzaldehyde oxime is another area of ongoing research. While it is generally considered safe for industrial use, proper handling and disposal practices are essential to minimize any potential environmental risks. Studies have shown that it can be biodegraded under certain conditions, which is an important consideration for its sustainable use.

In conclusion, 4-Methoxy-benzaldehyde oxime (CAS No. 3235-04-9) is a multifaceted compound with a broad range of applications in chemistry, pharmaceuticals, and materials science. Its unique chemical properties make it an invaluable intermediate in synthetic processes, while its potential for developing new drugs and advanced materials continues to drive research and innovation. As research progresses, it is likely that new applications and insights into the properties of this compound will emerge, further solidifying its importance in various scientific fields.

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