• 1. An integrated droplet-digital microfluidic system for on-demand droplet creation, mixing, incubation, and sorting?
  Lab Chip, 2019,19, 524-535
• 2. An asymmetric supercapacitor based on controllable WO3 nanorod bundle and alfalfa-derived porous carbon?
  Kanjun Sun,Fengting Hua,Shuzhen Cui,Yanrong Zhu,Hui Peng,Guofu Ma RSC Adv., 2021,11, 37631-37642
• 3. Acentric and chiral heterometallic inorganic–organic hybrid frameworks mediated by alkali or alkaline earth ions: synthesis and NLO properties
  Huabin Zhang,Shaowu Du CrystEngComm, 2014,16, 4059-4068
• 4. An aqueous ammonia sensor based on an inkjet-printed polyaniline nanoparticle-modified electrode
  Karl Crowley,Eimer O'Malley,Aoife Morrin,Malcolm R. Smyth,Anthony J. Killard Analyst, 2008,133, 391-399
• 5. An artificial enzyme cascade amplification strategy for highly sensitive and specific detection of breast cancer-derived exosomes?
  Huiying Xu,Lu Zheng,Yu Zhou,Bang-Ce Ye Analyst, 2021,146, 5542-5549

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzofurans Phthalic anhydrides
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzofurans Benzofuranones Phthalic anhydrides
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

4-Fluorophthalic Anhydride (CAS No. 319-03-9): An Overview of Its Properties, Applications, and Recent Research Developments

4-Fluorophthalic anhydride (CAS No. 319-03-9) is a versatile organic compound that has gained significant attention in the fields of chemistry, materials science, and pharmaceutical research. This compound is characterized by its unique structure, which includes a fluorine atom and an anhydride group, making it a valuable building block for various applications.

The chemical formula of 4-fluorophthalic anhydride is C₈H₃F₁O₃. It is a white to off-white crystalline solid with a molecular weight of 172.11 g/mol. The compound exhibits excellent thermal stability and low moisture sensitivity, which are crucial properties for its use in various chemical reactions and industrial processes.

In terms of physical properties, 4-fluorophthalic anhydride has a melting point of approximately 160-162°C. Its solubility in common organic solvents such as dichloromethane, acetone, and dimethylformamide (DMF) makes it easy to handle and process in laboratory settings. However, it is insoluble in water, which can be advantageous for certain applications where water sensitivity needs to be minimized.

The reactivity of 4-fluorophthalic anhydride is primarily driven by its anhydride group, which can undergo hydrolysis to form the corresponding carboxylic acid. This property allows it to participate in a wide range of chemical reactions, including esterification, amidation, and ring-opening reactions. The presence of the fluorine atom also imparts unique electronic and steric effects, making it a valuable reagent for the synthesis of fluorinated compounds.

In the pharmaceutical industry, 4-fluorophthalic anhydride has been explored as a key intermediate in the synthesis of various drugs and drug candidates. Fluorinated compounds are known for their enhanced biological activity and metabolic stability, which can lead to improved drug efficacy and reduced side effects. Recent studies have shown that derivatives of 4-fluorophthalic anhydride can be used to develop novel anti-inflammatory agents and anticancer drugs.

One notable application of 4-fluorophthalic anhydride is in the synthesis of fluorinated polymers. These polymers exhibit excellent thermal stability, chemical resistance, and mechanical properties, making them suitable for use in high-performance materials such as coatings, adhesives, and membranes. The unique combination of fluorine and anhydride functionalities in 4-fluorophthalic anhydride allows for the creation of polymers with tailored properties for specific applications.

In materials science, 4-fluorophthalic anhydride has been used as a monomer or comonomer in the preparation of functionalized polymers. These polymers can be designed to have specific functionalities such as hydrophobicity, oleophobicity, and low surface energy. Such properties are highly desirable in applications ranging from surface coatings to biomedical devices.

The environmental impact of 4-fluorophthalic anhydride has also been a subject of recent research. Studies have shown that the compound can be synthesized using green chemistry principles, minimizing the use of hazardous solvents and reducing waste generation. This aligns with the growing trend towards sustainable chemical processes and environmentally friendly materials.

In conclusion, 4-fluorophthalic anhydride (CAS No. 319-03-9) is a multifaceted compound with a wide range of applications in chemistry, materials science, and pharmaceutical research. Its unique structure and reactivity make it a valuable reagent for the synthesis of fluorinated compounds and functionalized polymers. Ongoing research continues to uncover new possibilities for its use in developing advanced materials and therapeutic agents.

• 175278-29-2(Methyl 5-Fluoro-2-Methyl Benzoate)
• 1494-08-2(8-fluorobenzo[e][2]benzofuran-1,3-dione)
• 110706-50-8(Dimethyl 4-fluorophthalate)
• 320-96-7(1,2-Benzenedicarboxylicacid, 4-fluoro-, 1,2-diethyl ester)
• 773135-70-9(Ethyl 4-fluoro-2,6-dimethylbenzoate)
• 700-85-6(5-fluoro-3H-isobenzofuran-1-one)
• 14659-60-0(Methyl 4-fluoro-2,6-dimethylbenzoate)
• 18959-30-3(4,5-Difluorophthalic anhydride)
• 23932-84-5(6-fluoro-1,3-dihydro-2-benzofuran-1-one)
• 174403-69-1(Methyl 4-fluoro-2-methylbenzoate)