• 1. Essential effect of the electrolyte on the mechanical and chemical degradation of LiNi0.8Co0.15Al0.05O2 cathodes upon long-term cycling??
  Xiaoming Liu,Zachary D. Hood,Wangda Li,Donovan N. Leonard,Arumugam Manthiram,Miaofang Chi J. Mater. Chem. A, 2021,9, 2111-2119
• 2. Emerging investigator series: kinetics of diopside reactivity for carbon mineralization in mafic–ultramafic rocks
  BrianaAguila,LandonHardee,H.ToddSchaef,SiavashZare,MohammadJavadAbdolhosseiniQomi,JarrodV.Crum,JadeE.HollimanJr.,ElenaTajueloRodriguez,LawrenceM.Anovitz,KevinM.Rosso,QuinR.S.Miller
• 3. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 4. Excited state dynamics of symmetric and asymmetric Cr3(dpa)4Cl2 measured using femtosecond transient absorption spectroscopy?
  Chao-Han Cheng,Wen-Zhen Wang,Shie-Ming Peng,I-Chia Chen Phys. Chem. Chem. Phys., 2017,19, 25471-25477
• 5. Examination of deposit in commercial diluted phosphoric acid
  Analyst, 1880,5, 146-147

• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Amines Secondary amines

Introduction to N,2,2-trimethylpropan-1-amine hydrochloride (CAS No. 31820-19-6)

N,2,2-trimethylpropan-1-amine hydrochloride, with the chemical formula C?H??ClN, is a significant compound in the field of pharmaceutical and biochemical research. This compound is widely recognized for its utility as an intermediate in the synthesis of various pharmacologically active molecules. Its hydrochloride salt form enhances its solubility in aqueous solutions, making it particularly valuable for applications in drug formulation and biochemical assays.

The structure of N,2,2-trimethylpropan-1-amine hydrochloride features a tertiary amine core substituted with three methyl groups on the adjacent carbon atom to the nitrogen. This structural motif contributes to its unique chemical properties, including a relatively high stability under standard conditions and a moderate basicity that allows it to participate in various organic transformations. The presence of the hydrochloride counterion further influences its reactivity and solubility profile, making it a versatile building block in synthetic chemistry.

In recent years, N,2,2-trimethylpropan-1-amine hydrochloride has garnered attention in the development of novel therapeutic agents. Its structural framework is reminiscent of several bioactive molecules that exhibit potent effects on neurological and cardiovascular systems. For instance, researchers have explored its potential as a precursor in the synthesis of compounds targeting neurotransmitter receptors. The tertiary amine functionality provides a scaffold for selective binding interactions with biological targets, offering a promising avenue for drug discovery.

One of the most compelling applications of N,2,2-trimethylpropan-1-amine hydrochloride lies in its role as an intermediate in the production of vasodilators and antihypertensive agents. The compound’s ability to undergo functional group modifications allows chemists to tailor its properties for specific pharmacological needs. Recent studies have demonstrated its utility in synthesizing analogs of known drugs that exhibit improved pharmacokinetic profiles and reduced side effects. This adaptability underscores its importance as a synthetic intermediate in medicinal chemistry.

Moreover, N,2,2-trimethylpropan-1-amine hydrochloride has found utility in biochemical research as a reference standard and reagent for enzyme inhibition studies. Its well-characterized structure and reactivity make it an ideal candidate for probing enzymatic mechanisms and developing enzyme-based assays. Such applications are critical for understanding metabolic pathways and identifying new therapeutic targets.

The synthesis of N,2,2-trimethylpropan-1-amine hydrochloride typically involves multi-step organic reactions starting from readily available precursors such as isobutylene or isobutyl chloride. Advances in catalytic methods have improved the efficiency and scalability of these synthetic routes, making the compound more accessible for industrial applications. The optimization of these processes has enabled researchers to produce high-purity batches suitable for sensitive pharmaceutical applications.

From a regulatory perspective, N,2,2-trimethylpropan-1-amine hydrochloride is subject to quality control measures to ensure consistency and safety in its use. Manufacturers adhere to Good Manufacturing Practices (GMP) to guarantee that the compound meets stringent purity standards required by pharmaceutical companies. These measures are essential for ensuring the reliability of downstream applications where this compound is used.

The future prospects of N,2,2-trimethylpropan-1-amine hydrochloride are promising as research continues to uncover new applications and synthetic methodologies. Innovations in computational chemistry and high-throughput screening may further enhance its utility in drug discovery efforts. Additionally, collaborations between academic institutions and pharmaceutical companies could lead to novel derivatives with enhanced therapeutic potential.

In conclusion,N, N, 2, 2,trimethylpropan-1-amine hydrochloride, (CAS No.31820-19-6) remains a cornerstone compound in pharmaceutical research due to its structural versatility and functional utility. Its role as an intermediate in drug synthesis and biochemical studies underscores its importance in advancing therapeutic solutions across multiple disease areas.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)