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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines Piperidines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines

Comprehensive Overview of 2-(Piperidine-1-sulfonyl)ethan-1-amine (CAS No. 31644-46-9): Properties, Applications, and Industry Insights

2-(Piperidine-1-sulfonyl)ethan-1-amine, identified by its CAS number 31644-46-9, is a specialized organic compound gaining traction in pharmaceutical and agrochemical research. This sulfonamide derivative features a unique molecular structure combining a piperidine ring with an ethylamine sulfonyl group, making it valuable for designing bioactive molecules. Recent studies highlight its role as a versatile intermediate in drug discovery, particularly for targeting neurological and metabolic pathways.

The compound's physicochemical properties contribute to its utility. With a molecular weight of 192.28 g/mol and moderate solubility in polar solvents, 2-(piperidine-1-sulfonyl)ethan-1-amine exhibits stability under standard laboratory conditions. Researchers appreciate its balanced lipophilicity (LogP ~1.2), which enhances membrane permeability in biological systems—a critical factor addressed in recent AI-driven drug design discussions. These characteristics align with current industry demands for fragment-based drug discovery (FBDD) building blocks.

In pharmaceutical applications, this compound serves as a key precursor for kinase inhibitors and GPCR modulators. Patent analyses reveal its incorporation into experimental compounds targeting neurodegenerative diseases—a trending topic in 2024 medical research. The sulfonamide moiety enables hydrogen bonding with biological targets, while the piperidine component contributes to spatial orientation, demonstrating the growing importance of molecular hybridization strategies in modern therapeutics.

From a synthetic chemistry perspective, CAS 31644-46-9 offers multiple derivatization sites. The primary amine group allows for amide bond formation, while the sulfonyl group participates in nucleophilic substitution reactions. This dual reactivity pattern makes it valuable for combinatorial chemistry approaches, particularly in developing small molecule libraries for high-throughput screening—an area frequently searched in medicinal chemistry databases.

Environmental and safety profiles of 2-(piperidine-1-sulfonyl)ethan-1-amine meet standard laboratory handling requirements. While not classified as hazardous under GHS criteria, proper PPE (personal protective equipment) including gloves and goggles is recommended during manipulation. The compound's stability at room temperature (up to 150°C) and low volatility make it suitable for green chemistry applications—a significant consideration for sustainable pharmaceutical manufacturing.

Analytical characterization of 31644-46-9 typically involves HPLC (High-Performance Liquid Chromatography) with UV detection (λmax ~210 nm) and LC-MS for purity verification. Nuclear Magnetic Resonance (NMR) spectra show distinctive peaks at δ 1.4-1.6 ppm (piperidine CH2), 2.8-3.0 ppm (sulfonyl-CH2), and 3.1-3.3 ppm (amine-CH2). These spectral fingerprints assist researchers in quality control—a frequent search topic among organic synthesis professionals.

The commercial availability of 2-(piperidine-1-sulfonyl)ethan-1-amine through specialty chemical suppliers has increased significantly since 2022, reflecting growing demand. Current market analysis suggests expanding applications in crop protection formulations, where its structural features contribute to systemic activity in plants. This aligns with global discussions on sustainable agriculture and reduced environmental impact—key concerns in contemporary agrochemical development.

Future research directions for CAS 31644-46-9 may explore its potential in proteolysis-targeting chimeras (PROTACs) and other targeted protein degradation technologies. The compound's modular structure could facilitate linker development in these cutting-edge therapeutic modalities—a hot topic in 2024 drug discovery conferences. Computational studies suggest possible interactions with protein-protein interaction interfaces, opening avenues for innovative therapeutic approaches.

Storage recommendations for 2-(piperidine-1-sulfonyl)ethan-1-amine include protection from moisture in sealed containers at 2-8°C. Technical documents emphasize compatibility with common organic solvents including DMSO, methanol, and dichloromethane—information highly sought after in chemical handling forums. The compound's shelf life typically exceeds 24 months when stored properly, ensuring reliable performance in multi-step syntheses.

In conclusion, 2-(piperidine-1-sulfonyl)ethan-1-amine (31644-46-9) represents a valuable tool for researchers developing next-generation therapeutics and agrochemicals. Its unique structural features, synthetic versatility, and growing commercial accessibility position it as a compound of interest in multiple life science sectors. As precision medicine and sustainable chemistry continue to dominate scientific discourse, this sulfonamide derivative will likely see expanded applications in coming years.

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