Cas no 31373-65-6 (Hippuryl-L-histidyl-L-leucine)

Hippuryl-L-histidyl-L-leucine is a synthetic tripeptide substrate widely used in biochemical and enzymatic research, particularly for studying angiotensin-converting enzyme (ACE) activity. Its structure mimics natural ACE substrates, enabling precise kinetic analysis and inhibitor screening. The peptide’s stability and specificity make it a reliable tool for in vitro assays, facilitating accurate measurement of ACE-related biochemical pathways. Its high purity and well-defined composition ensure reproducible results in research applications. Hippuryl-L-histidyl-L-leucine is particularly valuable in cardiovascular and hypertension studies, where understanding ACE mechanisms is critical. The compound’s consistent performance and compatibility with standard assay protocols underscore its utility in scientific investigations.
Hippuryl-L-histidyl-L-leucine structure
Hippuryl-L-histidyl-L-leucine structure
Product Name:Hippuryl-L-histidyl-L-leucine
CAS No:31373-65-6
MF:C21H27N5O5
MW:429.469584703445
MDL:MFCD00005205
CID:309553
PubChem ID:94418
Update Time:2025-05-22

Hippuryl-L-histidyl-L-leucine Chemical and Physical Properties

Names and Identifiers

    • L-Leucine,N-benzoylglycyl-L-histidyl-
    • HIPPURYL-HIS-LEU
    • Hippuryl-His-Leu-OH
    • HIPPURYL-L-HISTIDYL-L-LEUCINE
    • BENZOYL-GLY-HIS-LEU
    • Bz-Gly-His-Leu
    • BZ-GLY-HIS-LEU-OH
    • H-HIP-HIS-LEU-OH
    • HIPPURYL-HISTIDYL-LEUCINE
    • hippuryl-L-histdyl-L-leucine
    • hippuryl-L-histidinyl-L-leucine
    • N-Benzoyl-Gly-L-His-L-Leu-OH
    • N-hippuryl-His-Leu
    • (2S)-2-[(2S)-3-(1H-imidazol-4-yl)-2-[2-(phenylformamido)acetamido]propanamido]-4-methylpentanoic acid
    • benzoylglycyl-L-histidyl-L-leucine
    • n-hippuryl-l-histidyl-l-leucine
    • benzoyl-glycyl-histidyl-leucine
    • Hippuryl-His-Leu-OH (BZ-Gly-L-His-L-Leu-OH)
    • H1711
    • EINECS 250-597-9
    • 1212823-14-7
    • N-{1-Hydroxy-2-[(1-hydroxy-2-{[hydroxy(phenyl)methylidene]amino}ethylidene)amino]-3-(1H-imidazol-5-yl)propylidene}leucine
    • DTXSID30953414
    • NS00050799
    • HY-P4551
    • J-013566
    • 31373-65-6
    • (2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoic acid
    • SCHEMBL21925037
    • CS-0655091
    • N-Benzoyl-Gly-His-Leu
    • N-[2-([(Benzoylamino)acetyl]amino)-3-(1H-imidazol-4-yl)propanoyl]leucine #
    • MFCD00005205
    • (S)-2-((S)-2-(2-Benzamidoacetamido)-3-(1H-imidazol-4-yl)propanamido)-4-methylpentanoic acid
    • N-Hippuryl-L-histidyl-L-leucine hydrate
    • SCHEMBL1275443
    • N-(N-(N-benzoylglycyl)-L-histidinyl)-L-leucine
    • N-(N-(N-Benzoylglycyl)-L-histidyl)-L-leucine
    • rel-(S)-2-((S)-2-(2-benzamidoacetamido)-3-(1h-imidazol-4-yl)propanamido)-4-methylpentanoic acid
    • L-Leucine, N-[N-(N-benzoylglycyl)-L-histidyl]-
    • Hip-His-Leu
    • L-Leucine, N-(N-(N-benzoylglycyl)-L-histidyl)-
    • DA-64169
    • G87036
    • Hippuryl-L-histidyl-L-leucine
    • MDL： MFCD00005205
    • Inchi： 1S/C21H27N5O5/c1-13(2)8-17(21(30)31)26-20(29)16(9-15-10-22-12-24-15)25-18(27)11-23-19(28)14-6-4-3-5-7-14/h3-7,10,12-13,16-17H,8-9,11H2,1-2H3,(H,22,24)(H,23,28)(H,25,27)(H,26,29)(H,30,31)/t16-,17-/m0/s1
    • InChI Key： AAXWBCKQYLBQKY-IRXDYDNUSA-N
    • SMILES： O=C([C@H](CC1=CN=CN1)NC(CNC(C1C=CC=CC=1)=O)=O)N[C@H](C(=O)O)CC(C)C

Computed Properties

  • Exact Mass: 429.20100
  • Monoisotopic Mass: 429.20121898g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 9
  • Hydrogen Bond Acceptor Count: 14
  • Heavy Atom Count: 35
  • Rotatable Bond Count: 14
  • Complexity: 636
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 2
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: 16
  • XLogP3: 1.4
  • Topological Polar Surface Area: 153

Experimental Properties

  • Color/Form: White powder
  • Solubility: acetic acid: 50?mg/mL, clear, colorless
  • PSA: 153.28000
  • LogP: 1.65520
  • Solubility: acetic acid

Hippuryl-L-histidyl-L-leucine Security Information

  • WGK Germany：3
  • FLUKA BRAND F CODES：10-21

Hippuryl-L-histidyl-L-leucine Pricemore >>

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Hippuryl-L-histidyl-L-leucine Suppliers

Amadis Chemical Company Limited
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Audited Supplier Audited Supplier
(CAS:31373-65-6)Hippuryl-L-histidyl-L-leucine
Order Number:A854301
Stock Status:in Stock
Quantity:100mg/250mg
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 07:49
Price ($):174.0/400.0

Hippuryl-L-histidyl-L-leucine Related Literature

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Additional information on Hippuryl-L-histidyl-L-leucine

Comprehensive Analysis of Hippuryl-L-histidyl-L-leucine (CAS No. 31373-65-6): Applications and Research Insights

Hippuryl-L-histidyl-L-leucine (CAS No. 31373-65-6) is a synthetic tripeptide compound that has garnered significant attention in biochemical and pharmaceutical research. This peptide, composed of hippuric acid, L-histidine, and L-leucine, serves as a critical substrate for enzyme studies, particularly in the evaluation of angiotensin-converting enzyme (ACE) activity. Its unique structure and functional properties make it a valuable tool for researchers exploring cardiovascular health, enzyme kinetics, and peptide-based therapeutics.

In recent years, the demand for Hippuryl-L-histidyl-L-leucine has surged due to its role in biomedical research and drug development. With the growing focus on precision medicine and personalized therapies, this compound has become a focal point for studies investigating ACE inhibitors and their potential applications in managing hypertension and metabolic disorders. Researchers are also exploring its utility in diagnostic assays, where it aids in the quantification of enzyme activity and the screening of novel therapeutic agents.

The synthesis and purification of Hippuryl-L-histidyl-L-leucine require advanced techniques such as solid-phase peptide synthesis (SPPS) and high-performance liquid chromatography (HPLC). These methods ensure high purity and consistency, which are essential for reproducible experimental results. The compound's stability under various pH conditions and its solubility in aqueous solutions further enhance its practicality in laboratory settings.

From a commercial perspective, Hippuryl-L-histidyl-L-leucine is available through specialized biochemical suppliers and research reagent providers. Its pricing and availability are influenced by factors such as production scale, purity grade, and market demand. As the life sciences industry continues to expand, the compound's relevance in academic research and industrial applications is expected to grow.

In conclusion, Hippuryl-L-histidyl-L-leucine (CAS No. 31373-65-6) represents a versatile and indispensable component in modern biochemical research. Its applications span from enzyme assays to therapeutic development, aligning with contemporary trends in health innovation and scientific discovery. For researchers and industry professionals, understanding its properties and potential is key to unlocking new advancements in peptide science and molecular biology.

31373-65-6 (Hippuryl-L-histidyl-L-leucine) Related Products

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Amadis Chemical Company Limited
(CAS:31373-65-6)Hippuryl-L-histidyl-L-leucine
A854301
Purity:99%/99%
Quantity:100mg/250mg
Price ($):174.0/400.0
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