Cas no 31282-04-9 (Hygromycin B)
Hygromycin B Chemical and Physical Properties
Names and Identifiers
-
- Hygromycin B
- O-6-Amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1-2-3)-o-beta-D-talopyranosyl-(1-5)-2-deoxy-N3-methyl-D-streptamine
- Hygromycin B solution from Biological Fermentation
- Hygromycin B solution
- Hygromycin B powder
- Hygrovetine
- antihelmycin
- Destomycin A
- Hyaromycin B
- hydromycinb
- HYGROGOLD(TM)
- Hygromix
- hygromix2.4
- hygromix-8
- Hygromycin B, Streptomyces hygroscopicus, High Purity, in DI Water
- Hygrovetin
- CCG-269897
- HYGROMYCIN B [MART.]
- Hygromix 2.4
- O-6-AMINO-6-DEOXY-L-GLYCERO-D-GALACTO-HEPTOPYRANOSYLIDENE-(1->2-3)-O-.BETA.-D-TALOPYRANOSYL-(1->5)-2-DEOXY-N3-METHYL-D-STREPTAMINE
- 5-O-(2,3-O-(6-Amino-6-desoxyheptapyranosyliden)-beta-D-talopyranosyl)-2-desoxy-N'-methyl-D-streptamin
- C01925
- HYGROMYCIN B [GREEN BOOK]
- 31282-04-9
- D-Streptamine, O-6-amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1.fwdarw.2-3)-O-beta-D-talopyranosyl-(1.fwdarw.5)-2-deoxy-N3-methyl-
- DTXSID7041045
- CHEBI:16976
- D-Streptamine, O-6-amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1-2-3)-O-beta-D-talopyranosyl-(1-5)-2-deoxy-N-(sup 3)-methyl-
- (3aS,3'R,4S,4'S,5'R,6R,6'R,7S,7aS)-4-(((1R,2S,3R,5S,6R)-3-Amino-2,6-dihydroxy-5-(methylamino)cyclohexyl)oxy)-6'-((S)-1-amino-2-hydroxyethyl)-6-(hydroxymethyl)octahydro-3aH-spiro[[1,3]dioxolo[4,5-c]pyran-2,2'-pyran]-3',4',5',7-tetraol
- HY-B0490
- EINECS 250-545-5
- Hygromix 8, Hygromix 2.4
- 3XQ2233B0B
- AI3-29796
- HYGROMYCIN B (MART.)
- Hydromycin B
- DTXCID5021045
- D-Streptamine, O-6-amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1-2-3)-O-beta-D-talopyranosyl-(1-5)-2-deoxy-N3-methyl-
- DB11520
- AB01566876_01
- HYGROMYCIN-B
- Antibiotic A-396-II
- AKOS027328055
- s2908
- NCGC00188433-02
- O-6-AMINO-6-DEOXY-L-GLYCERO-D-GALACTO-HEPTOPYRANOSYLIDENE-(1->2-3)-O-beta-D-TALOPYRANOSYL-(1->5)-2-DEOXY-N3-METHYL-D-STREPTAMINE
- HYGROMYCIN B [MI]
- AI3-50155
- H1509
- Hygromycin B 100 microg/mL in Acetonitrile/Water
- D-Streptamine, O-6-amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene(1-2-3)-O-beta-D-talopyranosyl-(1->)-2-deoxy-N3-methyl-
- BRN 6755837
- (3R,3a'S,4S,4'S,5R,6R,6'R,7'S,7a'S)-4'-(((1R,2S,3R,5S,6R)-3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyl)oxy)-6-((S)-1-amino-2-hydroxyethyl)-6'-(hydroxymethyl)octahydro-4'H-spiro[pyran-2,2'-[1,3]dioxolo[4,5-c]pyran]-3,4,5,7'-tetraol
- D-STREPTAMINE, O-6-AMINO-6-DEOXY-L-GLYCERO-D-GALACTO-HEPTOPYRANOSYLIDENE-
- UNII-3XQ2233B0B
- FT-0627163
- Hyanthelmix
- 4-{[3-Amino-2,6-dihydroxy-5-(methylamino)cyclohexyl]oxy}-6'-(1-amino-2-hydroxyethyl)-6-(hydroxymethyl)tetrahydro-4H-spiro[1,3-dioxolo[4,5-c]pyran-2,2'-oxane]-3',4',5',7-tetrol (non-preferred name)
- D-Stretamine,3-O-[6-(1-amino-2-hydroxyethyl)tetrahydro-3,4,5-trihydroxy-2H-pyran-2-ylidene)-.beta.-D-talopyranosyl]-2-deoxy-N(sup3)methyl-
- D-Streptamine, O-6-amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1.fwdarw.2-3)-O-.beta.-D-talopyranosyl-(1.fwdarw.5)-2-deoxy-N1-methyl-
- CID 23777801
- DTXSID50860459
- Q27106388
- Hygrovectine
- SCHEMBL18763320
- 14918-35-5
- CHEBI:4454
- NSC-96877
- Destomysin
- 4-[3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyl]oxy-6'-(1-amino-2-hydroxyethyl)-6-(hydroxymethyl)spiro[4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-2,2'-oxane]-3',4',5',7-tetrol
- (2S,3'R,3aS,4S,4'S,5'R,6R,6'R,7S,7aS)-4-[(1R,2S,3R,5S,6R)-3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyl]oxy-6'-[(1R)-1-amino-2-hydroxyethyl]-6-(hydroxymethyl)spiro[4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-2,2'-oxane]-3',4',5',7-tetrol
- SCHEMBL692216
- (2R,3'R,3aS,4S,4'S,5'R,6R,6'R,7S,7aS)-4-[(1R,2S,3R,5S,6R)-3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyl]oxy-6'-(1-amino-2-hydroxyethyl)-6-(hydroxymethyl)spiro[4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-2,2'-oxane]-3',4',5',7-tetrol
- (1R,2S,3R,5S,6R)-3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyl O-6-amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1->2-3)-beta-D-talopyranoside
- O-6-amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1->2-3)-O-beta-D-talopyranosyl-(1->5)-2-deoxy-N(3)-methyl-D-streptamine
- MFCD06795479
- GRRNUXAQVGOGFE-KPBUCVLVSA-N
- AKOS026750002
- NS00011531
- Q418735
- SCHEMBL3109
- GLXC-25648
- (3'R,3aS,4S,4'R,5'R,6R,6'R,7S,7aS)-4-[(1R,2S,3R,5S,6R)-3-amino-2,6-dihydroxy-5-(methylamino)cyclohexoxy]-6'-[(1S)-1-amino-2-hydroxy-ethyl]-6-(hydroxymethyl)spiro[4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-2,2'-tetrahydropyran]-3',4',5',7-tetrol
- O-6-Amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1->2- 3)-O-.alpha.-D-talopyranosyl-(1->5)-2-deoxy-N3-
- CHEMBL4647156
- GS-5543
- H10464
- O-6-Amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1-2-3)-O-beta-D-talopyranosyl(1-5)-2-deoxy-N3-methyl-D-streptamine
- Hygromycin B from Streptomyces hygroscopicus, lyophilized powder
- Hygromycin B from Streptomyces hygroscopicus, plant cell culture tested, BioReagent, >=60% (HPLC), lyophilized powder
- BCBcMAP01_000235
- (2S,3R,3A'S,4S,4'S,5R,6R,6'R,7'S,7a'S)-4'-(((1R,2S,3R,5S,6R)-3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyl)oxy)-6-((R)-1-amino-2-hydroxyethyl)-6'-(hydroxymethyl)octahydro-4'H-spiro[pyran-2,2'-[1,3]dioxolo[4,5-c]pyran]-3,4,5,7'-tetraol
- 90% (HPLC)
- AC-32610
- Hygromycin B from Streptomyces hygroscopicus, powder, BioReagent, suitable for cell culture, suitable for insect cell culture
- AKOS032949592
- C20H37N3O13
- SMP1_000163
- 1217468-11-5
- Hygromycin B, from Streptomyces hygroscopicus
- (2S,3'R,3aS,4S,4'S,5'R,6R,6'R,7S,7aS)-4-{[(1R,2S,3R,5S,6R)-3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyl]oxy}-6'-[(1R)-1-amino-2-hydroxyethyl]-6-(hydroxymethyl)-tetrahydro-3aH-spiro[[1,3]dioxolo[4,5-c]pyran-2,2'-oxane]-3',4',5',7-tetrol
- Hygromycin B from Streptomyces hygroscopicus, Vetec(TM) reagent grade
- HB4420
- GRRNUXAQVGOGFE-XKIAHZFYSA-N
-
- MDL： MFCD06795479
- Inchi： 1S/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3/t5-,6-,7+,8-,9+,10-,11+,12-,13+,14-,15-,16+,17+,18-,19+,20+/m1/s1
- InChI Key： GRRNUXAQVGOGFE-XKIAHZFYSA-N
- SMILES： O1[C@]2([C@@H]([C@H]([C@H]([C@@H]([C@@H](CO)N)O2)O)O)O)O[C@H]2[C@H]([C@@H](CO)O[C@H]([C@@H]12)O[C@@H]1[C@H]([C@@H](C[C@@H]([C@H]1O)NC)N)O)O
Computed Properties
- Exact Mass: 527.23300
- Monoisotopic Mass: 527.233
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 11
- Hydrogen Bond Acceptor Count: 16
- Heavy Atom Count: 36
- Rotatable Bond Count: 6
- Complexity: 756
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 15
- Undefined Atom Stereocenter Count : 1
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Surface Charge: 0
- XLogP3: -6.6
- Topological Polar Surface Area: 272
Experimental Properties
- Color/Form: Yellowish brown amorphous powder with special smell
- Density: 1.4252 (rough estimate)
- Melting Point: 180°C(dec.)(lit.)
- Boiling Point: 897.6℃ at 760 mmHg
- Flash Point: 496.7±34.3 °C
- Refractive Index: 1.6300 (estimate)
- Solubility: H2O: 50?mg/mL As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 30 days.
- Water Partition Coefficient: Miscible with water, methanol, buffer solution and ethanol. Immiscible with less polar solvents.
- PSA: 272.06000
- LogP: -5.47910
- Merck: 4852
- pka: 7.1, 8.8(at 25℃)
- Specific Rotation: D20 +20.2° (c = 1 in water)
- Color/Form: 50?mg/mL
- Solubility: water
- Vapor Pressure: No data available
Hygromycin B Security Information
-
Symbol:
- Prompt：dangerous
- Signal Word：Danger
- Hazard Statement： H300+H310+H330H318,H334
- Warning Statement： P260,P264,P280,P284,P301+P310,P302+P350
- Hazardous Material transportation number：UN 3462
- WGK Germany：3
- Hazard Category Code： 26/27/28-41-42/43
- Safety Instruction： S22-S26-S28-S36/37/39-S45
- FLUKA BRAND F CODES：19
- Regulatory Condition Code：Class Q (sugars, alkaloids, antibiotics, hormones)
- RTECS：WK2130000
-
Hazardous Material Identification：
- HazardClass：6.1
- PackingGroup：I
- Storage Condition：Powder -20°C 3 years ? 4°C 2 years In solvent -80°C 6 months ? -20°C 1 month
- Hazard Level：6.1
- Safety Term：6.1
- Risk Phrases：R26/27/28; R41; R42/43
Hygromycin B Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| MedChemExpress | HY-B0490-10mM*1mLinDMSO |
Hygromycin B |
31282-04-9 | ≥98.0% | 10mM*1mLinDMSO |
￥550 | 2023-07-26 | |
| MedChemExpress | HY-B0490-200mg |
Hygromycin B |
31282-04-9 | ≥98.0% | 200mg |
￥500 | 2024-04-18 | |
| MedChemExpress | HY-B0490-500mg |
Hygromycin B |
31282-04-9 | ≥98.0% | 500mg |
￥800 | 2024-04-18 | |
| MedChemExpress | HY-B0490-1g |
Hygromycin B |
31282-04-9 | ≥98.0% | 1g |
￥1000 | 2024-04-18 | |
| MedChemExpress | HY-B0490-5g |
Hygromycin B |
31282-04-9 | ≥98.0% | 5g |
￥3300 | 2024-04-18 | |
| S e l l e c k ZHONG GUO | S2908-250mg |
Hygromycin B |
31282-04-9 | 97% | 250mg |
￥1180.84 | 2023-09-15 | |
| HE FEI BO MEI SHENG WU KE JI YOU XIAN ZE REN GONG SI | CH0716-1g |
Hygromycin B |
31282-04-9 | ≥98% | 1g |
￥530.00元 | 2023-09-15 | |
| HE FEI BO MEI SHENG WU KE JI YOU XIAN ZE REN GONG SI | CH0716-250mg |
Hygromycin B |
31282-04-9 | ≥98% | 250mg |
￥170.00元 | 2023-09-15 | |
| HE FEI BO MEI SHENG WU KE JI YOU XIAN ZE REN GONG SI | CH0716-5g |
Hygromycin B |
31282-04-9 | ≥98% | 5g |
￥2250.00元 | 2023-09-15 | |
| HE FEI BO MEI SHENG WU KE JI YOU XIAN ZE REN GONG SI | CFK547-1g (20ml) |
Hygromycin B |
31282-04-9 | ≥80% | 1g |
￥700元 | 2022-10-09 |
Hygromycin B Suppliers
Audited Supplier
Audited Supplier
Audited Supplier
Hygromycin B Related Literature
-
Helga Garcia,Rui Ferreira,Marija Petkovic,Jamie L. Ferguson,Maria C. Leit?o,H. Q. Nimal Gunaratne,Luís Paulo N. Rebelo Green Chem., 2010,12, 367-369
-
Yaling Zhang,Chunhui Dai,Shiwei Zhou,Bin Liu Chem. Commun., 2018,54, 10092-10095
-
J. Xu,T. J. Carrocci,A. A. Hoskins Chem. Commun., 2016,52, 549-552
-
Marcin Czapla,Jack Simons Phys. Chem. Chem. Phys., 2018,20, 21739-21745
-
Min Kim,Jae-Joon Lee,Tengling Ye,Panagiotis E. Keivanidis,Kilwon Cho J. Mater. Chem. C, 2020,8, 1686-1696
Additional information on Hygromycin B
Introduction to Hygromycin B and Its Applications in Modern Research
Hygromycin B, a naturally occurring antibiotic with the CAS number 31282-04-9, has emerged as a cornerstone in the field of molecular biology and biotechnology. This compound, belonging to the aminoglycoside class, is widely recognized for its potent antibacterial and antifungal properties. Its unique mechanism of action, which involves inhibiting protein synthesis in prokaryotic organisms, has made it an indispensable tool in various scientific applications.
The structure of Hygromycin B consists of a disaccharide core linked to an amino sugar, providing it with the ability to bind to the 30S ribosomal subunit of bacteria. This binding disrupts the translation process, ultimately leading to the production of non-functional proteins. The specificity of this interaction has been leveraged in research settings to selectively eliminate unwanted microbial contamination.
In recent years, Hygromycin B has found significant utility in genetic engineering and cell culture applications. Its ability to kill bacteria without affecting mammalian cells has made it a preferred choice for maintaining sterile conditions in laboratory environments. Furthermore, its use as a selection marker in transgenic organisms has been extensively documented, particularly in plant and animal models.
Recent advancements in synthetic chemistry have enabled the development of modified versions of Hygromycin B with enhanced properties. These derivatives exhibit improved stability and efficacy while maintaining their selectivity. Such modifications have opened new avenues for therapeutic applications, including potential uses in combating antibiotic-resistant bacteria.
The pharmaceutical industry has also shown interest in Hygromycin B due to its potential as a lead compound for drug development. Researchers are exploring its efficacy against various pathogens and its potential role in combination therapies. Additionally, studies have begun to investigate its effects on human cell lines, aiming to uncover new therapeutic targets.
One of the most intriguing aspects of Hygromycin B is its role in epigenetic research. Emerging evidence suggests that this compound may influence gene expression through mechanisms beyond its primary antibacterial action. This has sparked interest among scientists studying epigenetic modifications and their implications in diseases such as cancer and neurodegeneration.
The regulatory landscape for Hygromycin B remains favorable, with agencies like the FDA and EMA providing clear guidelines for its use in research and industrial applications. Its well-documented safety profile and extensive literature support its continued use across various sectors.
As our understanding of microbiology and genetics evolves, the applications of Hygromycin B are likely to expand further. Ongoing research is exploring novel uses for this compound, from improving agricultural practices to developing new medical treatments. The versatility and reliability of Hygromycin B ensure its place as a fundamental tool in modern scientific endeavors.
31282-04-9 (Hygromycin B) Related Products
- 13291-74-2(Gentamicin A)
- 59733-86-7(D-Streptamine,O-3-amino-3-deoxy-a-D-glucopyranosyl-(1®6)-O-[6-amino-6-deoxy-a-D-glucopyranosyl-(1®4)]-N1-[(2S)-4-amino-2-hydroxybutyl]-2-deoxy-)
- 65072-00-6((2R,3R,4S,5S,6S)-5-amino-2-[[(2R,3S,4R,6S,7R)-7-amino-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl]oxy-4-hydroxy-3-(methylamino)-2,3,4,4a,6,7,8,8a-octahydropyrano[3,2-b]pyran-2-yl]oxy]-6-(hydroxymethyl)oxane-3,4-diol)
- 56283-52-4(D-Streptamine,O-4-amino-4-deoxy-a-D-glucopyranosyl-(1®8)-O-(8R)-2-amino-2,7-dideoxy-7-(methylamino)-D-erythro-a-D-gluco-octodialdo-1,5:8,4-dipyranosyl-(1®4)-2-deoxy- (9CI))
- 102367-13-5(D-Streptamine,O-3-amino-3-deoxy-a-D-glucopyranosyl-(1®6)-O-[a-D-glucopyranosyl-(1®4)]-2-deoxy-N3-methyl- (9CI))
- 11005-98-4(D-Streptamine,O-6-amino-6-deoxy-L-glycero-D-gluco-heptopyranosylidene-(1®2-3)-O-b-D-mannopyranosyl-(1®5)-2-deoxy-N1,N3-dimethyl-)
- 106288-50-0(D-Streptamine,O-2-amino-2-deoxy-a-D-glucopyranosyl-(1®4)-O-[O-2,6-diamino-2,6-dideoxy-b-L-idopyranosyl-(1®3)-b-D-ribofuranosyl-(1®5)]-2-deoxy-N3-methyl- (9CI))
- 28048-39-7(2H-Pyrano[2,3-b][1,4]benzodioxin-4,4a,7,9(10aH)-tetrol,octahydro-2-methyl-6,8-bis(methylamino)-, (2R,4R,4aS,5aR,6S,7S,8R,9S,9aR,10aS)-)
- 37321-09-8(APRAMYCIN)
- 14918-35-5(D-Streptamine,O-6-amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1®2-3)-O-b-D-talopyranosyl-(1®5)-2-deoxy-N1-methyl-)
