Cas no 312300-45-1 ((5-Amino-2-methoxyphenyl)carbamic Acid tert-Butyl Ester)

(5-Amino-2-methoxyphenyl)carbamic Acid tert-Butyl Ester is a protected aniline derivative widely used in organic synthesis and pharmaceutical research. The tert-butyl carbamate (Boc) group serves as a robust protecting group for the amine functionality, enabling selective reactions at other sites of the molecule under acidic or basic conditions. Its methoxy substituent further enhances stability and modulates reactivity, making it valuable for constructing complex heterocycles or intermediates. The compound’s crystalline solid form ensures ease of handling and precise stoichiometric use. Its compatibility with common synthetic methodologies, such as cross-coupling or nucleophilic substitution, makes it a versatile building block for drug discovery and fine chemical applications.
(5-Amino-2-methoxyphenyl)carbamic Acid tert-Butyl Ester structure
312300-45-1 structure
Product Name:(5-Amino-2-methoxyphenyl)carbamic Acid tert-Butyl Ester
CAS No:312300-45-1
MF:C12H18N2O3
MW:238.282923221588
MDL:MFCD08059242
CID:300737
PubChem ID:22344747
Update Time:2025-06-11

(5-Amino-2-methoxyphenyl)carbamic Acid tert-Butyl Ester Chemical and Physical Properties

Names and Identifiers

    • Carbamic acid,N-(5-amino-2-methoxyphenyl)-, 1,1-dimethylethyl ester
    • (5-AMINO-2-METHOXYPHENYL)CARBAMIC ACID TERT-BUTYL ESTER,
    • tert-butyl 5-amino-2-methoxyphenylcarbamate
    • tert-butyl N-(5-amino-2-methoxyphenyl)carbamate
    • (5-amino-2-methoxyphenyl)-carbamic acid tert-butyl ester
    • 1,1-dimethylethyl [5-amino-2-(methyloxy)phenyl]carbamate
    • tert-Butyl (5-amino-2-methoxyphenyl)carbamate
    • SCHEMBL6118023
    • FT-0769274
    • CS-0341119
    • AKOS000169123
    • Z285919676
    • (5-Amino-2-methoxy-phenyl)-carbamic acid tert-butyl ester, AldrichCPR
    • tert-Butyl(5-amino-2-methoxyphenyl)carbamate
    • AVVCSVAHHQOYFE-UHFFFAOYSA-N
    • AB00998594-01
    • DTXSID30625048
    • SB36525
    • (5-Amino-2-methoxy-phenyl)-carbamic acid t-butyl ester
    • MFCD08059242
    • EN300-37129
    • 312300-45-1
    • (5-AMINO-2-METHOXY-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER
    • J-018282
    • (5-amino-2-methoxyphenyl)carbamic acid tert-butyl ester
    • G32142
    • DA-42840
    • (5-Amino-2-methoxyphenyl)carbamic Acid tert-Butyl Ester
    • MDL： MFCD08059242
    • Inchi： 1S/C12H18N2O3/c1-12(2,3)17-11(15)14-9-7-8(13)5-6-10(9)16-4/h5-7H,13H2,1-4H3,(H,14,15)
    • InChI Key： AVVCSVAHHQOYFE-UHFFFAOYSA-N
    • SMILES： O(C(NC1C=C(C=CC=1OC)N)=O)C(C)(C)C

Computed Properties

  • Exact Mass: 238.13200
  • Monoisotopic Mass: 238.13174244g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 5
  • Heavy Atom Count: 17
  • Rotatable Bond Count: 5
  • Complexity: 263
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 1.8
  • Topological Polar Surface Area: 73.6?2

Experimental Properties

  • PSA: 73.58000
  • LogP: 3.27860

(5-Amino-2-methoxyphenyl)carbamic Acid tert-Butyl Ester Customs Data

  • HS CODE：2924299090
  • Customs Data：

    China Customs Code:

    2924299090

    Overview:

    2924299090. Other cyclic amides(Including cyclic carbamates)(Including their derivatives as well as their salts). VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:30.0%

    Declaration elements:

    Product Name, component content, use to, packing

    Summary:

    2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

(5-Amino-2-methoxyphenyl)carbamic Acid tert-Butyl Ester Pricemore >>

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(5-Amino-2-methoxyphenyl)carbamic Acid tert-Butyl Ester Related Literature

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Additional information on (5-Amino-2-methoxyphenyl)carbamic Acid tert-Butyl Ester

Comprehensive Overview of (5-Amino-2-methoxyphenyl)carbamic Acid tert-Butyl Ester (CAS No. 312300-45-1)

The compound (5-Amino-2-methoxyphenyl)carbamic Acid tert-Butyl Ester (CAS No. 312300-45-1) is a specialized organic intermediate widely utilized in pharmaceutical and agrochemical research. Its unique molecular structure, featuring both an amino and a methoxy group, makes it a valuable building block for synthesizing more complex molecules. Researchers often seek this compound for its role in drug discovery and medicinal chemistry, particularly in the development of novel therapeutic agents targeting neurological and inflammatory conditions.

In recent years, the demand for high-purity intermediates like (5-Amino-2-methoxyphenyl)carbamic Acid tert-Butyl Ester has surged, driven by advancements in precision medicine and bioconjugation techniques. This compound’s tert-butyl ester moiety enhances its stability, making it suitable for multi-step synthetic routes. Laboratories frequently inquire about its solubility, storage conditions, and compatibility with coupling reagents, reflecting its practical importance in modern organic synthesis.

From an industrial perspective, CAS No. 312300-45-1 is often discussed in the context of green chemistry and sustainable synthesis. Manufacturers emphasize optimizing its production to minimize waste and energy consumption, aligning with global trends toward eco-friendly chemical processes. Analytical methods such as HPLC and NMR are routinely employed to verify its purity, ensuring compliance with stringent quality control standards required in pharmaceutical applications.

Another area of interest is the compound’s potential in proteomics research, where its derivatization capabilities enable the study of protein interactions. This aligns with the growing focus on biomarker discovery and personalized therapeutics. Researchers also explore its use in fluorescence labeling, leveraging its aromatic amine functionality for imaging applications in cellular biology.

Given its versatility, (5-Amino-2-methoxyphenyl)carbamic Acid tert-Butyl Ester is frequently referenced in patents and academic publications related to small-molecule inhibitors and enzyme modulators. Its structural features are particularly relevant for designing compounds with improved bioavailability and target selectivity. As the scientific community continues to investigate its applications, this intermediate remains a critical tool for innovators in life sciences and material chemistry.

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