• 1. Establishing new scaling relations on two-dimensional MXenes for CO2 electroreduction?
  Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890
• 2. Ester-directed orthogonal dual C–H activation and ortho aryl C–H alkenylation via distal weak coordination?
  Manickam Bakthadoss,Tadiparthi Thirupathi Reddy,Vishal Agarwal,Duddu S. Sharada Chem. Commun., 2022,58, 1406-1409
• 3. Evidence of field induced slow magnetic relaxation in cis-[Co(hfac)2(H2O)2] exhibiting tri-axial anisotropy with a negative axial component?
  Denis V. Korchagin,Elena A. Yureva,Alexander V. Akimov,Eugenii Ya. Misochko,Gennady V. Shilov,Artem D. Talantsev,Roman B. Morgunov,Alexander A. Shakin,Sergey M. Aldoshin,Boris S. Tsukerblat Dalton Trans., 2017,46, 7540-7548
• 4. Emulsion technologies for multicellular tumour spheroid radiation assays?
  Kay S. McMillan,Anthony G. McCluskey,Annette Sorensen,Marie Boyd,Michele Zagnoni Analyst, 2016,141, 100-110
• 5. Dissociation of aryl sulfonyl phthalimide radical anions: relevance to the biological activity of arylsulfonyl amides?
  Abdelaziz Houmam,Emad M. Hamed Chem. Commun., 2012,48, 11328-11330

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

Nε-Boc-D-Lysine: A Comprehensive Overview

Nε-Boc-D-Lysine, also known by its CAS registry number 31202-69-4, is a significant compound in the field of organic chemistry and biochemistry. This compound is a derivative of D-lysine, a naturally occurring amino acid, with a tert-butoxycarbonyl (Boc) group attached to the ε-amino group of lysine. The Boc group is commonly used as a protecting group in peptide synthesis, making Nε-Boc-D-Lysine an essential reagent in various biochemical and pharmaceutical applications.

The structure of Nε-Boc-D-Lysine consists of a central carbon atom bonded to an amino group, a carboxyl group, a hydrogen atom, and the D-lysine side chain modified with the Boc group. The Boc group is introduced to protect the ε-amino functionality during peptide synthesis, ensuring that the lysine residue does not participate in unintended reactions during the synthesis process. This protection strategy is critical for achieving high yields and purity in peptide production.

Recent studies have highlighted the importance of Nε-Boc-D-Lysine in the development of novel therapeutic agents. For instance, researchers have explored its role in the synthesis of cyclic peptides, which are known for their potent bioactivity and selectivity. By incorporating Nε-Boc-D-Lysine into peptide sequences, scientists can design molecules with enhanced stability and affinity for specific targets, paving the way for innovative treatments in oncology and infectious diseases.

In addition to its role in peptide synthesis, Nε-Boc-D-Lysine has been utilized in the field of materials science. Researchers have investigated its potential as a building block for self-assembling peptides, which can form nanofibers and hydrogels with unique mechanical properties. These materials hold promise for applications in tissue engineering and drug delivery systems, where biocompatibility and controlled release mechanisms are crucial.

The synthesis of Nε-Boc-D-Lysine typically involves a multi-step process starting from D-lysine hydrochloride. The first step involves activation of the carboxyl group using an appropriate coupling agent, followed by selective protection of the ε-amino group with tert-butoxycarbonyl chloride (BocCl). This two-step process ensures that only the ε-amino group is modified while preserving the other functional groups for subsequent reactions.

From an analytical standpoint, Nε-Boc-D-Lysine can be characterized using various spectroscopic techniques such as nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS). NMR spectroscopy provides detailed information about the molecular structure, including the stereochemistry of the chiral centers. MS analysis confirms the molecular weight and purity of the compound, ensuring that it meets rigorous quality control standards.

One area where Nε-Boc-D-Lysine has shown significant potential is in enantioselective catalysis. By incorporating this compound into chiral catalysts, chemists can achieve high enantioselectivity in asymmetric reactions, which are essential for producing optically active compounds used in pharmaceuticals and agrochemicals.

Furthermore, recent advancements in green chemistry have led to more sustainable methods for synthesizing Nε-Boc-D-Lysine. Researchers have explored the use of biodegradable solvents and enzymatic catalysts to reduce environmental impact while maintaining high yields and product quality.

In conclusion, Nε-Boc-D-Lysine (CAS No 31202-69-4) is a versatile compound with wide-ranging applications in peptide synthesis, materials science, catalysis, and drug development. Its unique properties make it an invaluable tool for researchers seeking to design novel molecules with tailored functionalities. As ongoing research continues to uncover new applications for this compound, its significance in both academic and industrial settings will undoubtedly grow.

• 114360-55-3(H-D-Dab(boc)-OH)
• 10270-94-7((S)-2-Amino-4-((tert-butoxycarbonyl)amino)butanoic Acid)
• 62087-87-0(L-ORNITHINE, N5-[(TRICYCLO[3.3.1.13,7]DEC-1-YLOXY)CARBONYL]-)
• 117833-90-6(Heptanoic acid, 2-amino-7-[[(1,1-dimethylethoxy)carbonyl]amino]-, (R)-)
• 583870-06-8(HEPTANOIC ACID, 2,7-BIS[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]-)
• 2418-95-3((S)-2-Amino-6-((tert-butoxycarbonyl)amino)hexanoic acid)
• 13650-49-2(N-δ-Boc-L-Ornithine)
• 184576-63-4(N-δ-BOC-D-Ornithine)
• 129850-63-1(Hexadecanoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-, (±)-)
• 139260-78-9(Eicosanoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-)