• 1. Exchanged ligands on the surface of a giant cluster: [(MoO3)176(H2O)63(CH3OH)17Hn](32 – n)–
  Chem. Commun., 1998, 1501-1502
• 2. Evolving better nanoparticles: Genetic algorithms for optimising cluster geometries
  Dalton Trans., 2003, 4193-4207
• 3. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 4. Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals?
  Eric Besson,Stéphane Gastaldi,Emily Bloch,Selma Aslan,Hakim Karoui,Olivier Ouari,Micael Hardy Analyst, 2019,144, 4194-4203
• 5. Emerging investigator series: bacteriophages as nano engineering tools for quality monitoring and pathogen detection in water and wastewater
  Fereshteh Bayat Environ. Sci.: Nano, 2021,8, 367-389

N-Butyl 4-Fluorobenzenesulfonamide (CAS No. 312-67-4): An Overview of Its Properties, Applications, and Recent Research

N-Butyl 4-fluorobenzenesulfonamide (CAS No. 312-67-4) is a versatile compound with a wide range of applications in the fields of chemistry, biology, and pharmaceuticals. This compound is characterized by its unique molecular structure, which includes a butyl group, a fluorobenzene ring, and a sulfonamide functional group. These structural features contribute to its distinct chemical and biological properties, making it a valuable component in various research and industrial processes.

The molecular formula of N-Butyl 4-fluorobenzenesulfonamide is C₁₀H₁₂FO₂S, and its molecular weight is approximately 218.26 g/mol. The compound is typically a white crystalline solid at room temperature and is soluble in common organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO). Its solubility in water is limited, which can be advantageous in certain applications where controlled solubility is required.

In the context of pharmaceutical research, N-Butyl 4-fluorobenzenesulfonamide has gained attention due to its potential as a scaffold for the development of new drugs. The presence of the fluorine atom in the benzene ring can significantly influence the compound's pharmacological properties, such as its metabolic stability and binding affinity to target proteins. Recent studies have explored the use of fluorinated compounds like N-Butyl 4-fluorobenzenesulfonamide in the design of more potent and selective drugs for various therapeutic areas.

One notable application of N-Butyl 4-fluorobenzenesulfonamide is in the field of cancer research. A study published in the Journal of Medicinal Chemistry (2021) reported that derivatives of this compound exhibited significant antiproliferative activity against several cancer cell lines. The researchers found that the introduction of fluorine atoms enhanced the compound's ability to inhibit key enzymes involved in cancer cell proliferation, making it a promising lead for further drug development.

Beyond its potential as a drug candidate, N-Butyl 4-fluorobenzenesulfonamide has also been investigated for its use as an intermediate in organic synthesis. Its sulfonamide functional group can participate in various chemical reactions, such as nucleophilic substitution and coupling reactions, making it a valuable building block for the synthesis of more complex molecules. This versatility has led to its use in the production of agrochemicals, dyes, and other fine chemicals.

In addition to its synthetic utility, N-Butyl 4-fluorobenzenesulfonamide has been studied for its environmental impact. A recent review article in Environmental Science & Technology (2020) highlighted the importance of understanding the fate and behavior of fluorinated compounds in aquatic systems. The study found that while N-Butyl 4-fluorobenzenesulfonamide itself is not highly toxic, its degradation products may have different environmental profiles that need to be carefully monitored.

The safety profile of N-Butyl 4-fluorobenzenesulfonamide has also been evaluated in several toxicological studies. These studies have generally concluded that the compound is well-tolerated at low concentrations and does not pose significant health risks when handled properly. However, standard safety precautions should be followed when working with this compound to minimize exposure and ensure safe handling practices.

In conclusion, N-Butyl 4-fluorobenzenesulfonamide (CAS No. 312-67-4) is a multifaceted compound with a wide range of applications in pharmaceutical research, organic synthesis, and environmental science. Its unique molecular structure provides a foundation for further exploration and development in these fields. As ongoing research continues to uncover new properties and applications, N-Butyl 4-fluorobenzenesulfonamide remains an important compound for scientists and researchers worldwide.

• 606969-06-6(N-(5-Aminopentyl)-2,4-difluorobenzenesulfonamide)
• 383-48-2(N-Ethyl 4-fluorobenzenesulfonamide)
• 304006-89-1(Benzenesulfonamide, N-[[4-(aminomethyl)cyclohexyl]methyl]-4-fluoro-)
• 565-40-2(N-Cyclohexyl 4-fluorobenzenesulfonamide)
• 433-05-6(4-Fluoro-N-propylbenzenesulfonamide)
• 606969-05-5(N-(6-Aminohexyl)-2,4-difluorobenzenesulfonamide)
• 330467-35-1(Benzenesulfonamide, 4-fluoro-N-(2-methylpropyl)-)
• 391935-17-4(Benzenesulfonamide, N-(cyclopropylmethyl)-4-fluoro-)
• 5491-22-5(N-butyl-2-fluorobenzenesulfonamide)
• 425654-95-1(N-Cyclopropyl 4-fluorobenzenesulfonamide)