• 1. Evolution in surface coverage of CH3NH3PbI3?XClXvia heat assisted solvent vapour treatment and their effects on photovoltaic performance of devices
  Dhirendra K. Chaudhary,Pramendra Kumar,Lokendra Kumar RSC Adv., 2016,6, 94731-94738
• 2. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 3. Emulsion soft templating of carbide-derived carbon nanospheres with controllable porosity for capacitive electrochemical energy storage?
  M. Zeiger,N. J?ckel,P. Strubel,L. Borchardt,R. Reinhold,W. Nickel,J. Eckert,V. Presser,S. Kaskel J. Mater. Chem. A, 2015,3, 17983-17990
• 4. EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis?
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• 5. Enantio- & chemo-selective preparation of enantiomerically enriched aliphatic nitro alcohols using Candida parapsilosis ATCC 7330
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridine carboxaldehydes

Professional Introduction to 5-Fluoropyridine-2-carbaldehyde (CAS No. 31181-88-1)

5-Fluoropyridine-2-carbaldehyde is a significant intermediate in the field of pharmaceutical chemistry, widely recognized for its versatile applications in the synthesis of various bioactive molecules. With the CAS number 31181-88-1, this compound has garnered considerable attention due to its role in developing innovative therapeutic agents. The presence of a fluorine atom at the 5-position and an aldehyde group at the 2-position imparts unique chemical properties that make it invaluable in medicinal chemistry.

The compound's structure, featuring a pyridine core, is a cornerstone in the design of small-molecule drugs. Pyridine derivatives are well-documented for their pharmacological activities, including antimicrobial, anti-inflammatory, and anticancer properties. The introduction of fluorine into the pyridine ring enhances the metabolic stability and binding affinity of the molecule, making it an attractive scaffold for drug development.

In recent years, 5-fluoropyridine-2-carbaldehyde has been extensively studied for its potential in generating novel pharmacophores. Researchers have leveraged its reactivity to synthesize a diverse array of derivatives, each with distinct biological functions. For instance, studies have demonstrated its utility in creating kinase inhibitors, which are crucial in targeting various forms of cancer. The aldehyde functionality allows for further derivatization through condensation reactions, enabling the construction of complex molecular architectures.

The pharmaceutical industry has shown particular interest in this compound due to its role in developing next-generation antibiotics. The fluorine atom's ability to influence electron distribution and binding interactions has been exploited to create compounds with enhanced antibacterial properties. Furthermore, the aldehyde group serves as a versatile handle for further functionalization, allowing chemists to tailor molecules for specific therapeutic applications.

Advances in synthetic methodologies have further highlighted the importance of 5-fluoropyridine-2-carbaldehyde. Modern techniques such as transition-metal-catalyzed cross-coupling reactions have enabled more efficient and scalable production of this intermediate. These innovations have not only improved yield but also reduced costs, making it more accessible for industrial applications. As a result, pharmaceutical companies are increasingly incorporating this compound into their drug discovery pipelines.

The biological activity of derivatives derived from 5-fluoropyridine-2-carbaldehyde has been a focal point of research. Studies have revealed that modifications at the 3-position and 4-position of the pyridine ring can significantly alter the pharmacological profile of the molecule. For example, substituents such as amino groups or heterocycles can enhance binding affinity to target proteins while minimizing off-target effects. This flexibility underscores the compound's potential as a building block for developing tailored therapeutics.

In conclusion, 5-fluoropyridine-2-carbaldehyde (CAS No. 31181-88-1) represents a critical component in modern drug discovery and development. Its unique structural features and reactivity make it indispensable for synthesizing a wide range of bioactive molecules. As research continues to uncover new applications and synthetic strategies, this compound is poised to remain at the forefront of pharmaceutical innovation.

• 884495-44-7(3-Fluoro-4-methylpicolinaldehyde)
• 1214333-57-9(4-(4-Fluorophenyl)pyridine-2-carbaldehyde)
• 884495-34-5(5-fluoro-6-methylpyridine-2-carbaldehyde)
• 260430-93-1(6-Fluoroquinoline-2-carbaldehyde)
• 614752-47-5( )
• 31181-53-0(5-Fluoro-2-methylpyridine)
• 884495-48-1(3-fluoro-6-methylpyridine-2-carbaldehyde)
• 31224-43-8(3-Fluoropyridine-2-carbaldehyde)
• 780801-58-3(3,5-difluoropyridine-2-carbaldehyde)
• 717871-83-5(2-Pyridinecarbonylchloride, 5-fluoro-)