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  Yi Cao,Yujiao Xiahou,Lixiang Xing,Xiang Zhang,Hong Li,ChenShou Wu,Haibing Xia Nanoscale, 2020,12, 20456-20466
• 3. Emerging investigators
  Polym. Chem., 2015,6, 5501-5502
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  Guang Xu,Wei Zhang,Ying Zhang,Xiaoxia Zhao,Ping Wen,Di Ma RSC Adv., 2018,8, 19353-19361
• 5. Enabling stable MnO2 matrix for aqueous zinc-ion battery cathodes?
  Yiding Jiao,Liqun Kang,Jasper Berry-Gair,Kit McColl,Jianwei Li,Haobo Dong,Hao Jiang,Ryan Wang,Furio Corà,Dan J. L. Brett,Ivan P. Parkin J. Mater. Chem. A, 2020,8, 22075-22082

• Solvents and Organic Chemicals Organic Compounds Organometallic compounds Organometalloid compounds Organosilicon compounds Alkoxysilanes
• Other Chemical Reagents Organic Metal Reagents

Research Brief on N-(3-Trimethoxysilylpropyl) Morpholine (CAS: 31024-54-1): Recent Advances and Applications

N-(3-Trimethoxysilylpropyl) Morpholine (CAS: 31024-54-1) is a silane coupling agent with significant applications in the chemical, biological, and pharmaceutical industries. This compound, characterized by its unique morpholine and trimethoxysilyl functional groups, has been widely studied for its ability to improve adhesion, surface modification, and biocompatibility in various materials. Recent research has focused on its role in drug delivery systems, biomedical coatings, and hybrid material synthesis, highlighting its versatility and potential for innovation in the field.

One of the most notable advancements in the application of N-(3-Trimethoxysilylpropyl) Morpholine is its use in the development of controlled-release drug delivery systems. Studies have demonstrated that this compound can be employed to functionalize silica nanoparticles, enhancing their stability and biocompatibility while enabling targeted drug release. For instance, a 2023 study published in the Journal of Controlled Release reported that silica nanoparticles modified with N-(3-Trimethoxysilylpropyl) Morpholine exhibited improved loading efficiency for hydrophobic drugs and sustained release profiles, making them promising candidates for cancer therapy.

In addition to drug delivery, this silane coupling agent has shown promise in the field of biomedical coatings. Researchers have utilized N-(3-Trimethoxysilylpropyl) Morpholine to modify the surfaces of medical implants, such as titanium alloys, to enhance their osseointegration and reduce bacterial adhesion. A recent study in Biomaterials Science (2024) revealed that coatings incorporating this compound significantly improved the biocompatibility and antibacterial properties of orthopedic implants, reducing postoperative infection rates and promoting faster tissue regeneration.

Another emerging application of N-(3-Trimethoxysilylpropyl) Morpholine is in the synthesis of hybrid organic-inorganic materials. Its ability to act as a bridging agent between organic polymers and inorganic substrates has been exploited to create materials with tailored mechanical and thermal properties. For example, a 2024 study in Advanced Materials demonstrated that incorporating this compound into sol-gel derived hybrid coatings resulted in materials with enhanced durability and corrosion resistance, suitable for industrial and biomedical applications.

Despite these advancements, challenges remain in optimizing the synthesis and application of N-(3-Trimethoxysilylpropyl) Morpholine. Recent research has focused on addressing issues such as hydrolysis stability, reaction kinetics, and scalability. A 2023 review in Chemical Reviews highlighted the need for further studies to elucidate the mechanistic pathways of this compound in various applications, which could pave the way for more efficient and sustainable utilization.

In conclusion, N-(3-Trimethoxysilylpropyl) Morpholine (CAS: 31024-54-1) continues to be a compound of significant interest in the chemical, biological, and pharmaceutical fields. Its diverse applications, from drug delivery to biomedical coatings and hybrid materials, underscore its potential to drive innovation. Future research should focus on overcoming existing challenges and exploring novel applications to fully harness its capabilities.

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• 820252-10-6(1-Propanamine, N-[2-(oxiranylmethoxy)ethyl]-3-(trimethoxysilyl)-N-[3-(trimethoxysilyl)prop yl]-)
• 130570-74-0(2-Oxiranemethanamine,N,N-bis[3-(trimethoxysilyl)propyl]-)
• 18784-74-2(3-(triethoxysilyl)-N,N-bis-3-(triethoxysilyl)-propyl-Propane-1-amine Propane-1-amine,3-(triethoxysilyl)-N,N-bis-3-(triethoxysilyl)-propyl-)
• 81137-59-9(2,8,9-Trioxa-5-aza-1-silabicyclo[3.3.3]undecane, 1-(3-ethoxypropyl)-)
• 918314-10-0(2-Oxiranemethanamine, N-[3-(triethoxysilyl)propyl]-, (2S)-)
• 214362-07-9(2-Oxa-7,10-diaza-3-siladodecan-12-ol,7-(2-hydroxyethyl)-3,3-dimethoxy-10-[3-(trimethoxysilyl)propyl]-)
• 87928-37-8(1-Propanaminium, N-(2-hydroxyethyl)-N,N-dimethyl-3-(trimethoxysilyl)-, chloride (1:1))
• 7538-44-5(Bis(2-hydroxyethyl)aminopropyltriethoxysilane)
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