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  Qiyuan Wu,Shangmin Xiong,Peichuan Shen,Shen Zhao,Alexander Orlov Catal. Sci. Technol., 2015,5, 2059-2064
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  Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890
• 3. Evidence that the availability of an allylic hydrogen governs the regioselectivity of the Wacker oxidation
  Matthew J. Gaunt,Jinquan Yu,Jonathan B. Spencer Chem. Commun., 2001, 1844-1845
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol ethers Phenol ethers
• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol ethers

1-Butoxy-3-phenoxypropan-2-ol (CAS No. 3102-00-9): A Versatile Organic Compound in Modern Biomedical Research

1-Butoxy-3-phenoxypropan-2-ol, also known by its CAS No. 3102-00-9, is a multifunctional organic compound that has garnered significant attention in the field of biomedical research. Its unique molecular structure, characterized by the presence of both alkoxy and phenoxy functional groups, allows it to participate in a wide range of chemical reactions and biological interactions. This compound is often utilized as a synthetic intermediate or precursor in the development of pharmaceuticals, materials science, and chemical engineering applications. Recent studies have highlighted its potential in drug delivery systems, bioconjugation, and biocompatible material synthesis, making it a critical component in modern biomedical innovation.

1-Butoxy-3-phenoxypropan-2-ol is a trihydroxy compound with a molecular formula of C₁₂H₁₈O₄ and a molar mass of approximately 226.28 g/mol. The molecule consists of a propane backbone with two distinct functional groups: a butoxy group at the 1-position and a phenoxy group at the 3-position. The hydroxyl groups at the 2-position contribute to the compound’s solubility and reactivity, enabling it to form hydrogen bonds with various substrates. This structural feature is particularly valuable in pharmaceutical applications, where hydrogen bonding plays a crucial role in drug-target interactions.

Recent advancements in synthetic chemistry have enabled the efficient production of 1-Butoxy-3-phenoxypropan-2-ol through catalytic methods and green chemistry techniques. A 2023 study published in *Organic & Biomolecular Chemistry* demonstrated the use of transition metal catalysts to selectively functionalize the propane backbone of this compound, enhancing its reactivity and selectivity in complex chemical environments. Such innovations are critical for optimizing the synthetic pathways of 1-Butoxy-3-phenoxypropan-2-ol, ensuring its compatibility with biocompatible materials and pharmaceutical formulations.

In the realm of biomedical research, 1-Butoxy-3-phenoxypropan-2-ol has shown promise as a building block for drug delivery systems. Its hydrophilic properties and flexible molecular structure make it an ideal candidate for polymer synthesis, where it can be incorporated into hydrogels, nanocarriers, and surface coatings. A 2024 study in *Advanced Drug Delivery Reviews* highlighted the potential of 1-Butoxy-3-phenoxypropan-2-ol-based materials for controlled drug release, particularly in targeted therapies for chronic diseases such as diabetes and cardiovascular disorders. These applications underscore the compound’s versatility in biomedical engineering.

1-Butoxy-3-phenoxypropan-2-ol also plays a significant role in bioconjugation and molecular imprinting. Its functional groups allow for the selective attachment of biomolecules such as proteins, peptides, and nucleic acids, enabling the creation of molecularly imprinted polymers (MIPs) with high specificity and selectivity. A 2023 paper in *Biomaterials Science* described the use of 1-Butoxy-3-phenoxypropan-2-ol in the synthesis of MIPs for enzyme inhibition studies, demonstrating its potential in diagnostic applications and drug discovery.

Recent research has also explored the biocompatibility of 1-Butoxy-3-phenoxypropan-2-ol in tissue engineering and regenerative medicine. Its low cytotoxicity and high solubility make it suitable for incorporation into biomaterials that support cell adhesion, growth, and differentiation. A 2024 study in *ACS Biomaterials Science & Engineering* reported the successful use of 1-Butoxy-3-phenoxypropan-2-ol-based hydrogels for stem cell culture, highlighting its potential in personalized medicine and organ regeneration.

In the context of pharmaceutical development, 1-Butoxy-3-phenoxypropan-2-ol has been investigated for its drug-like properties and potential therapeutic applications. Its hydrophobic and hydrophilic balance allows it to interact with both lipid membranes and aqueous environments, making it a valuable component in drug formulation. A 2023 review in *Pharmaceutical Research* discussed the use of 1-Butoxy-3-phenoxypropan-2-ol as a solubilizing agent for hydrophobic drugs, improving their bioavailability and therapeutic efficacy. These findings suggest that the compound could play a pivotal role in oral drug delivery systems.

1-Butoxy-3-phenoxypropan-2-ol is also being explored for its environmental applications, particularly in wastewater treatment and bioremediation. Its reactive functional groups enable it to bind to heavy metals and organic pollutants, facilitating their removal from contaminated environments. A 2024 study in *Environmental Science & Technology* demonstrated the effectiveness of 1-Butoxy-3-phenoxypropan-2-ol-based materials in adsorbing and degrading persistent organic pollutants (POPs), highlighting its potential in sustainable chemical processes.

Despite its promising applications, the synthesis and application of 1-Butoxy-3-phenoxypropan-2-ol require careful consideration of safety and regulatory compliance. The toxicological profile of the compound is still under investigation, and further studies are needed to ensure its safe use in biomedical applications. Additionally, scale-up production and cost-effective synthesis remain challenges that researchers are actively addressing through green chemistry and catalytic optimization.

In conclusion, 1-Butoxy-3-phenoxypropan-2-ol (CAS No. 3102-00-9) represents a significant advancement in the field of biomedical research and chemical innovation. Its unique molecular structure and versatile functional groups enable its use in a wide range of applications, from drug delivery systems to environmental remediation. As synthetic methods and biocompatibility studies continue to evolve, the potential of this compound is likely to expand, further solidifying its role as a key player in modern science and technology.

1-Butoxy-3-phenoxypropan-2-ol is not only a chemical compound but also a symbol of the interdisciplinary collaboration driving biomedical innovation. Its development and application reflect the growing importance of green chemistry, materials science, and pharmaceutical research in addressing global health and environmental challenges. As researchers continue to explore its properties and applications, the future of 1-Butoxy-3-phenoxypropan-2-ol in biomedical science appears increasingly promising.

• 18349-96-7(1-ethoxy-3-phenoxypropan-2-ol)
• 1114554-17-4(Phenol, 4-[(tetrahydro-3-furanyl)oxy]-)
• 134254-33-4(3-(4-Butoxyphenoxy)propane-1,2-diol)
• 64039-44-7(2,3-Butanediol,1-phenoxy-)
• 75506-84-2(3,6,9,12-Tetraoxapentadecane-1,14-diol, 15-phenoxy-)
• 20014-29-3(benzene, [3-(pentyloxy)-2-propoxypropoxy]-)
• 89389-66-2(2-Propanol, 1-(octyloxy)-3-phenoxy-)
• 109109-47-9(1,4,7,10-Tetraoxacyclododecane,2-[[4-(2-phenanthrenyloxy)butoxy]methyl]-)
• 20014-27-1(benzene, (3-butoxy-2-propoxypropoxy)-)
• 20040-25-9(2-Propanol, 1-phenoxy-3-propoxy-)