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Methyl 2-Aminopyrimidine-5-Carboxylate (CAS No. 308348-93-8): A Comprehensive Overview

Methyl 2-Aminopyrimidine-5-Carboxylate, a compound with the CAS registry number 308348-93-8, has garnered significant attention in the fields of organic chemistry, pharmacology, and materials science. This compound is a derivative of pyrimidine, a heterocyclic aromatic ring system that plays a pivotal role in various biological processes and synthetic applications. The structure of Methyl 2-Aminopyrimidine-5-Carboxylate consists of a pyrimidine ring with an amino group at position 2 and a methyl ester group at position 5, making it a versatile molecule for further functionalization and exploration.

Recent advancements in synthetic chemistry have enabled the efficient synthesis of Methyl 2-Aminopyrimidine-5-Carboxylate through multi-component reactions and modular approaches. These methods not only enhance the scalability of production but also pave the way for the incorporation of this compound into more complex molecular frameworks. Researchers have demonstrated that the methyl ester group at position 5 can be readily transformed into other functional groups, such as acids or amides, through simple hydrolysis or coupling reactions. This flexibility underscores its potential as a building block in drug discovery and materials synthesis.

In the realm of pharmacology, Methyl 2-Aminopyrimidine-5-Carboxylate has shown promise as a lead compound for developing bioactive agents. Studies have revealed that its pyrimidine core can interact with various biological targets, including enzymes, receptors, and nucleic acids. For instance, recent research has highlighted its ability to modulate kinase activity, making it a candidate for anti-cancer drug development. Additionally, its amino group at position 2 facilitates hydrogen bonding interactions, which are crucial for binding to protein surfaces and influencing enzymatic function.

The application of Methyl 2-Aminopyrimidine-5-Carboxylate extends beyond pharmacology into materials science. Its aromaticity and functionalizable groups make it an attractive candidate for designing organic semiconductors and optoelectronic materials. Researchers have explored its use in constructing π-conjugated systems, which are essential for applications such as organic light-emitting diodes (OLEDs) and photovoltaic devices. The methyl ester group at position 5 can be tailored to optimize electronic properties, thereby enhancing device performance.

From an environmental standpoint, the synthesis and application of Methyl 2-Aminopyrimidine-5-Carboxylate align with green chemistry principles. Modern synthetic strategies emphasize the use of renewable feedstocks, catalytic processes, and minimal waste generation. These approaches not only reduce the ecological footprint but also ensure the sustainable production of this compound for various industries.

In conclusion, Methyl 2-Aminopyrimidine-5-Carboxylate (CAS No. 308348-93-8) stands as a testament to the versatility and potential of pyrimidine derivatives in contemporary science. Its unique structure, coupled with recent advancements in synthesis and application techniques, positions it as a valuable asset in drug discovery, materials science, and beyond. As research continues to unravel its full potential, this compound is poised to contribute significantly to both academic and industrial advancements.

• 5571-03-9(5-Pyrimidinecarboxylic acid, 2-methyl-, methyl ester (7CI,8CI,9CI))
• 287714-36-7(5-Pyrimidinecarboxylicacid, 2-(dimethylamino)-, methyl ester)
• 38373-50-1(Methyl 2-hydrazino-5-pyrimidinecarboxylate)
• 5388-21-6(2-(Methylamino)pyrimidine-5-carboxylic acid)
• 34253-01-5(Methyl pyrimidine-5-carboxylate)
• 40929-50-8(Ethyl 5-pyrimidinecarboxylate)
• 57401-76-0(Ethyl 2-aminopyrimidine-5-carboxylate)
• 148741-62-2(2-Isopropylamino-5-methoxycarbonylpyrimidine)
• 64224-68-6(5-Pyrimidinecarboxylicacid, 2-(dimethylamino)-, ethyl ester)
• 3167-50-8(2-Aminopyrimidine-5-carboxylic acid)