Cas no 305-03-3 (Chlorambucil)

Chlorambucil is a nitrogen mustard alkylating agent used primarily in chemotherapy for the treatment of chronic lymphocytic leukemia (CLL) and certain lymphomas. As a derivative of mechlorethamine, it functions by forming covalent bonds with DNA, leading to cross-linking and inhibition of DNA replication and transcription. Its oral bioavailability and relatively slow metabolic clearance allow for convenient dosing regimens, making it suitable for long-term management. Chlorambucil is particularly valued for its selective activity against lymphoid tissues, reducing systemic toxicity compared to broader-spectrum alkylating agents. Its well-established efficacy and manageable side-effect profile have made it a cornerstone in hematologic malignancy therapy for decades.
Chlorambucil structure
Chlorambucil structure
Product Name:Chlorambucil
CAS No:305-03-3
MF:C14H19Cl2NO2
MW:304.212162256241
MDL:MFCD00021783
CID:36773
PubChem ID:2708
Update Time:2025-11-02

Chlorambucil Chemical and Physical Properties

Names and Identifiers

    • Chlorambucil
    • 4-(p-bis(2-chloroethyl)aminophenyl)butyric acid
    • 4-(p-bis(beta-chloroethyl)aminophenyl)butyric acid
    • 4-(p-(N,N-Di-2-chloroethyl)aminophenyl)butyric acid
    • 4-(p-N,N-Di-(beta-chloroethyl)aminophenyl)butyric acid
    • 4-[bis(2-chloroethyl)amino]benzenebutanoic acid
    • 4-[Bis(2-chloroethyl)aminophenyl]butyric acid
    • Ambochlorin
    • Amboclorin
    • cb 1348
    • Cb l348
    • Chloroambucil
    • Chloraminophen
    • Chlorobutin
    • Ecloril
    • Elcoril
    • Leukersan
    • Leukoran
    • Linfolizin
    • Linfolysin
    • N,N-Di-(2-chloroethyl)-gamma-(p-aminophenyl)butyric acid
    • Phenylbutyric acid nitrogen mustard
    • gamma-(p-bis(2-chloroethyl)aminophenyl)butyric acid
    • 4-(4-[Bis(2-chloroethyl)amino]phenyl)butyric acid 4-[Bis(2-chloroethyl)amino]benzenebutyric acid
    • Chlocambucil
    • 4-[4-[bis(2-chloroethyl)amino]phenyl]butanoic acid
    • CB-1348
    • WR-139013
    • 4-(4-[Bis(2-chloroethyl)amino]phenyl)butyric acid
    • 4-[Bis(2-chloroethyl)amino]benzenebutyric acid
    • 4-[4-[Bis(2-chloroethyl)amino]phenyl]butyric Acid
    • CHLORAMBUCIL [MART.]
    • N,N-Di-2-chloroethyl-.gamma.-p-aminophenylbutyric acid
    • Phenylbuttersaeure-lost [German]
    • Chlorambucil, United States Pharmacopeia (USP) Reference Standard
    • Butanoic acid, 4-(bis(2-chloroethyl)amino) benzene
    • SR-01000000062-7
    • HSDB 3026
    • KBio3_001191
    • NSC 3088
    • CHLORAMBUCIL [EP MONOGRAPH]
    • NCGC00015199-08
    • NCGC00023250-00
    • Q415939
    • NCGC00015199-06
    • SR-01000000062-2
    • AB00051938-15
    • Chlorambucil, purum, >=98.0% (T)
    • Spectrum5_000677
    • Spectrum3_000336
    • NCGC00023250-08
    • Leukeran
    • para-N,N-Di(beta-chloroethyl)aminophenyl butyric acid
    • KBioSS_000558
    • GTPL7143
    • Lympholysin
    • phenyl)butanoic acid
    • GS-6200
    • gamma-[p-Di(2-chloroethyl)aminophenyl]butyric acid
    • AKOS024319346
    • .gamma.-(p-bis(2-chloroethyl)aminophenyl)butyric acid
    • 4-(Bis(2-chloroethyl)amino)phenylbutyric acid
    • NCGC00015199-03
    • NCGC00015199-13
    • CCRIS 126
    • AMY33445
    • CHLORAMBUCIL [USP MONOGRAPH]
    • NS00009960
    • CHLORAMBUCIL [ORANGE BOOK]
    • gamma-(p-bis(2-chloroethyl)aminophenyl)butyricacid
    • SR-01000000062-4
    • FT-0617365
    • N,N-Di-2-chloroethyl-gamma-para-aminophenyl butyric acid
    • NCGC00015199-16
    • LEUKERAN (TN)
    • H10484
    • Lopac-C-0253
    • Butyric acid, 4-(p-(bis(2-chloroethyl)amino)phenyl)
    • Prestwick3_001079
    • BRN 0999011
    • NC00555
    • Spectrum2_000065
    • EINECS 206-162-0
    • HMS3652P08
    • Chlorambucil for system suitability, European Pharmacopoeia (EP) Reference Standard
    • 4-(p-Bis(.beta.-chloroethyl)aminophenyl)butyric acid
    • SR-01000000062
    • Prestwick1_001079
    • CCG-39872
    • BPBio1_001208
    • CHLORAMBUCIL [IARC]
    • SCHEMBL4308
    • IDI1_000688
    • Chlorbutinum
    • p-N,N-Di-(beta-chloroethyl)aminophenyl butyric acid
    • Elcorin
    • CHLORAMBUCIL [WHO-DD]
    • NCGC00015199-20
    • BSPBio_001098
    • p-(N,N-Di-2-chloroethyl)aminophenyl butyric acid
    • 4-(Bis(2-chloroethyl)amino)benzenebutanoic acid
    • CAS-305-03-3
    • NCI-C03485
    • 4-[p-[Bis(2-chloroethyl)amino]phenyl]butyric acid
    • Tox21_302996
    • Leukeran tablets
    • CHLORAMBUCIL [VANDF]
    • Butanoic acid, 4-(bis(2-chloroethyl)amino)benzene-
    • HMS3259I10
    • CHEBI:28830
    • MLS001076130
    • HMS2090M19
    • HMS2235A04
    • AB00051938_16
    • 18D0SL7309
    • BRD-K29458283-001-17-4
    • Spectrum4_000273
    • NCGC00023250-05
    • Rcra waste number U035
    • 4-[p-Bis(.beta.-chloroethyl)aminophenyl]butyric acid
    • NCGC00023250-09
    • NCI-3088
    • KBio2_005694
    • Chlorbutine
    • NSC-3088
    • Chlorobutine
    • Clorambucile
    • SY031075
    • .gamma.-(p-bis(2-chloroethyl)aminophenyl)butyricacid
    • Clorambucilo
    • HY-13593
    • Chlorambucil,(S)
    • Phenylbuttersaeure-lost
    • NINDS_000688
    • .gamma.-[p-bis(2-chloroethyl)aminophenyl]butyric acid
    • NSC-756674
    • NCGC00023250-03
    • NCGC00015199-01
    • AI3-26083
    • NSC3088
    • NCGC00023250-04
    • W-106940
    • Chlorbutin
    • N,N-Di-2-chloroethyl-gamma-p-aminophenylbutyric acid
    • KBio2_003126
    • Chlorambucil, European Pharmacopoeia (EP) Reference Standard
    • Tox21_201390
    • NCGC00015199-02
    • HMS2098G20
    • NCGC00015199-19
    • WLN: QV3R DN2G2G
    • NCGC00015199-15
    • NCGC00023250-07
    • DB00291
    • DivK1c_000688
    • BCP28394
    • BP-24028
    • 4-(4-(bis(2-chloroethyl)amino)
    • CHLORAMBUCIL [HSDB]
    • LP00227
    • Tox21_110096
    • DTXCID30263
    • 4-14-00-01715 (Beilstein Handbook Reference)
    • para-(Di(2-chloroethyl)aminophenyl)butyric acid
    • BRD-K29458283-001-04-2
    • C06900
    • Kyselina 4-(N,N-bis-(2-chlorethyl)-p-aminofenyl)maselna [Czech]
    • KBio2_000558
    • MFCD00021783
    • Kyselina 4-(N,N-bis-(2-chlorethyl)-p-aminofenyl)maselna
    • RCRA waste no. U035
    • Chlorambucil with impurity G
    • Butyric acid, 4-(p-[bis(2-chloroethyl)amino]phenyl)-
    • HMS2091A22
    • C2939
    • CHLORAMBUCIL [MI]
    • BSPBio_001971
    • 4-(4-[Bis(2-chloroethyl)amino]phenyl)butanoic acid #
    • Z1552153009
    • gamma-(p-Di(2-chloroethyl)aminophenyl)butyric acid
    • UNII-18D0SL7309
    • SDCCGSBI-0050215.P005
    • Epitope ID:139977
    • C 0253
    • EN300-123640
    • MLS000028443
    • SPBio_002999
    • NCGC00015199-07
    • NSC756674
    • NCGC00015199-12
    • Benzenebutanoic acid, 4-[bis(2-chloroethyl)amino]-
    • chlorambucilddv
    • CHLORAMBUCILUM [WHO-IP LATIN]
    • HMS1571G20
    • D00266
    • CHLORAMBUCIL [JAN]
    • Chlorambucilum
    • CHEMBL515
    • NCGC00015199-04
    • Chlorambucil [USP:INN:BAN]
    • Opera_ID_51
    • Chlorambucil (JAN/USP/INN)
    • NCGC00023250-10
    • 4-[4-(N,N-bis(2-chloroethyl)-amino]phenyl)butanoic acid
    • AB00051938-14
    • NCGC00258941-01
    • NCGC00015199-17
    • Lopac0_000227
    • NCI60_002639
    • A18607
    • SPECTRUM1500171
    • NCGC00015199-14
    • 4-(p-(Bis(2-chloroethyl)amino)phenyl)butyric acid
    • Chloraminophene
    • 305-03-3
    • Benzenebutanoic acid, 4-(bis(2-chloroethyl)amino)-
    • Chlorambucil for system suitability
    • HMS502C10
    • 4-(4-(Bis(2-chloroethyl)amino)phenyl)butanoic acid
    • .gamma.-[p-Di(2-chloroethyl)aminophenyl]butyric acid
    • Clorambucilo [INN-Spanish]
    • Prestwick2_001079
    • KBio1_000688
    • SMR000058372
    • Tox21_110096_1
    • HMS1920M15
    • CHLORAMBUCIL [INN]
    • Chloorambucol
    • CS-3118
    • 4[p-Bis(.beta.-chloroethyl)aminophenyl]butyric acid
    • NCGC00256464-01
    • Butyric acid, 4-[p-[bis(2-chloroethyl)amino]phenyl]-
    • C14H19Cl2NO2
    • CHLORAMBUCIL [WHO-IP]
    • KBioGR_000766
    • 4-(4-(Bis(2-chloroethyl)amino)phenyl)butanoicacid
    • DTXSID7020263
    • CHLORAMBUCIL [USP-RS]
    • AB00051938
    • SPBio_000249
    • SW197258-4
    • s4288
    • NCGC00023250-06
    • Chlorambucilum [INN-Latin]
    • NCGC00015199-11
    • Pharmakon1600-01500171
    • Clorambucile [DCIT]
    • NCGC00015199-05
    • p-(N,N-Di-2-chlorethylaminophenyl)butyric acid
    • SBI-0050215.P004
    • Prestwick0_001079
    • NCGC00015199-10
    • Spectrum_000118
    • BDBM50003677
    • Butyric acid, 4-(p-bis(2-chloroethyl)aminophenyl)-
    • EU-0100227
    • NCGC00015199-09
    • p-N,N-Di-(.beta.-chloroethyl)aminophenyl butyric acid
    • HMS3372O04
    • BRD-K29458283-001-05-9
    • 4-[Bis(2-chloroethyl)amino]phenylbutyric acid
    • 4-{4-[bis(2-chloroethyl)amino]phenyl}butanoic acid
    • BRD-K29458283-001-29-9
    • DB-047794
    • p-(N, N-Di-2-chloroethyl)aminophenyl butyric acid
    • Chlorambucil (Standard)
    • CHLORAMBUCIL (USP MONOGRAPH)
    • Alti-chlorambucil
    • CB1348
    • NCL-CO3485
    • BUTYRIC ACID, 4-(P-(BIS(2-CHLOROETHYL)AMINO)PHENYL)-
    • Benzenebutanoic acid, 4-[bis(2-chloroethyl)amino]-(9CI)
    • P-(N,N-DI-2-CHLORETHYLAMINOPHENYL BUTYRIC ACID
    • p-N, N-Di-(beta-chloroethyl)aminophenyl butyric acid
    • Chlorambucilum (INN-Latin)
    • Chlorambucil (USP:INN:BAN)
    • butyric acid, 4-(p-bis(2-chloroethyl)aminophenyl)
    • Celkeran
    • L01AA02
    • CHLORAMBUCIL (IARC)
    • clorambucil
    • CHLORAMBUCIL (MART.)
    • CHLORAMBUCIL (EP MONOGRAPH)
    • p-N, N-Di-(.beta.-chloroethyl)aminophenyl butyric acid
    • HY-13593R
    • Benzenebutanoic acid, alpha-amino-4-(bis(2-chloroethyl)amino)-(9CI)
    • 206-162-0
    • GAMMA-[P-BIS(2-CHLOROETHYL)AMINOPHENYL]BUTYRIC ACID
    • Clorambucilo (INN-Spanish)
    • CHLORAMBUCIL (USP-RS)
    • MDL： MFCD00021783
    • Inchi： 1S/C14H19Cl2NO2/c15-8-10-17(11-9-16)13-6-4-12(5-7-13)2-1-3-14(18)19/h4-7H,1-3,8-11H2,(H,18,19)
    • InChI Key： JCKYGMPEJWAADB-UHFFFAOYSA-N
    • SMILES： ClCCN(CCCl)C1C=CC(=CC=1)CCCC(=O)O

Computed Properties

  • Exact Mass: 303.07900
  • Monoisotopic Mass: 303.079284
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 19
  • Rotatable Bond Count: 9
  • Complexity: 250
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: nothing
  • XLogP3: nothing
  • Topological Polar Surface Area: 40.5

Experimental Properties

  • Color/Form: Beige powder
  • Density: 1.2486 (rough estimate)
  • Melting Point: 65.0 to 69.0 deg-C
  • Boiling Point: 459.8°C at 760 mmHg
  • Flash Point: 232.1 oC
  • Refractive Index: 1.6070 (estimate)
  • Solubility: DMSO : ≥ 24 mg/mL (78.89 mM)
  • Water Partition Coefficient: <0.01 g/100 mL at 22 oC
  • Stability/Shelf Life: Stable, but may be light sensitive. Store cold. Incompatible with strong oxidizing agents.
  • PSA: 40.54000
  • LogP: 3.37790
  • λmax: 588(DMSO aq.)(lit.)
  • Merck: 2073
  • Vapor Pressure: 0.0±1.2 mmHg at 25°C

Chlorambucil Security Information

Chlorambucil Customs Data

  • HS CODE：2922499990
  • Customs Data：

    China Customs Code:

    2922499990

    Overview:

    2922499990 Other amino acids and their esters and their salts(Except those containing more than one oxygen-containing group). VAT:17.0% Tax refund rate:9.0% Regulatory conditions:AB(Customs clearance form for Inbound Goods,Customs clearance form for outbound goods) MFN tariff:6.5% general tariff:30.0%

    Declaration elements:

    Product Name, component content, use to, The color of ethanolamine and its salt should be reported, The package of ethanolamine and its salt shall be declared

    Regulatory conditions:

    A.Customs clearance form for Inbound Goods
    B.Customs clearance form for outbound goods

    Inspection and quarantine category:

    P.Imported animals and plants\Quarantine of animal and plant products
    Q.Outbound animals and plants\Quarantine of animal and plant products
    R.Sanitary supervision and inspection of imported food
    S.Sanitary supervision and inspection of exported food
    M.Import commodity inspection
    N.Export commodity inspection

    Summary:

    HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

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Chlorambucil Suppliers

Amadis Chemical Company Limited
Gold Member
Audited Supplier Audited Supplier
(CAS:305-03-3)Chlorambucil
Order Number:A18607
Stock Status:in Stock
Quantity:5g/25g
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 04:06
Price ($):293.0/1027.0

Chlorambucil Related Literature

Related Categories

Additional information on Chlorambucil

Chlorambucil (CAS No. 305-03-3): A Comprehensive Guide to Its Properties and Applications

Chlorambucil, with the CAS number 305-03-3, is a well-known alkylating agent belonging to the nitrogen mustard family. This compound has been widely studied and utilized in various fields due to its unique chemical properties and biological activity. In this article, we will delve into the details of Chlorambucil, exploring its structure, mechanism of action, applications, and recent advancements in research.

The chemical name for Chlorambucil is 4-[bis(2-chloroethyl)amino]benzenebutanoic acid, and it is often referred to by its brand names Leukeran and Linfolysin. Its molecular formula is C14H19Cl2NO2, and it has a molecular weight of 304.22 g/mol. The compound is typically a white to pale yellow crystalline powder, soluble in organic solvents like ethanol and acetone but poorly soluble in water.

One of the most frequently asked questions about Chlorambucil is: "How does Chlorambucil work?" The answer lies in its mechanism as an alkylating agent. It forms covalent bonds with DNA, leading to cross-linking of DNA strands and ultimately inhibiting DNA replication and transcription. This property makes it particularly useful in certain therapeutic applications, where controlled cell proliferation inhibition is desired.

Recent trends in Chlorambucil research have focused on optimizing its delivery systems to enhance efficacy while minimizing side effects. Scientists are exploring novel formulations such as liposomal Chlorambucil and Chlorambucil conjugates with targeting moieties. These advancements address common search queries like "new developments in Chlorambucil therapy" and "improved Chlorambucil formulations", reflecting the growing interest in more targeted approaches.

The stability of Chlorambucil (CAS 305-03-3) is another important consideration for researchers and manufacturers. Proper storage conditions (typically 2-8°C in airtight containers protected from light) are crucial to maintain its potency. Stability studies often investigate Chlorambucil degradation products and Chlorambucil shelf life, topics that frequently appear in scientific literature and patent applications.

From a synthetic chemistry perspective, the production of Chlorambucil involves several key steps, including the reaction of p-aminophenylbutyric acid with ethylene oxide followed by chlorination. Process optimization for Chlorambucil synthesis remains an active area of research, with particular attention to improving yield and purity while reducing environmental impact.

Analytical methods for Chlorambucil characterization have evolved significantly. Modern techniques such as HPLC analysis of Chlorambucil, mass spectrometry of Chlorambucil, and NMR characterization of Chlorambucil provide comprehensive quality control. These methods answer common technical questions like "how to analyze Chlorambucil purity" and "Chlorambucil analytical standards".

The global market for Chlorambucil and related compounds continues to grow, driven by both research and therapeutic needs. Market analysis reports often highlight Chlorambucil price trends and Chlorambucil suppliers as key search terms for industry professionals. Quality certifications such as GMP Chlorambucil and USP Chlorambucil standards are increasingly important for manufacturers.

Recent publications have explored the potential of Chlorambucil derivatives with modified pharmacological profiles. Structure-activity relationship studies investigate how changes to the Chlorambucil molecule affect its properties, addressing research questions like "Chlorambucil structure optimization" and "novel Chlorambucil analogs".

Environmental considerations for Chlorambucil handling and disposal are subject to ongoing research. Studies on Chlorambucil environmental fate and Chlorambucil degradation pathways help establish proper safety protocols, responding to concerns about pharmaceutical compounds in the environment.

In conclusion, Chlorambucil (CAS 305-03-3) remains a compound of significant scientific and medical interest. Its unique properties continue to inspire research into improved formulations, delivery systems, and applications. As technology advances, we can expect to see more innovations surrounding this important molecule, addressing both current challenges and future opportunities in the field.

305-03-3 (Chlorambucil) Related Products

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Amadis Chemical Company Limited
(CAS:305-03-3)Chlorambucil
A18607
Purity:99%/99%
Quantity:5g/25g
Price ($):293.0/1027.0
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