• 1. An aptasensor for detection of potassium ions based on RecJf exonuclease mediated signal amplification
  Bidou Wang,Xifeng Chen Analyst, 2014,139, 5695-5699
• 2. Aggregation-induced chiroptical generation and photoinduced switching of achiral azobenzene-alt-fluorene copolymer endowed with left- and right-handed helical polysilanes?
  Hailing Chen,Lu Yin,Meng Liu,Laibing Wang,Michiya Fujiki,Wei Zhang RSC Adv., 2019,9, 4849-4856
• 3. Aluminium alkyl and aryloxide complexes of pyrazine and bipyridines: synthesis and structure?
  Doug Ogrin,Laura H. van Poppel,Simon G. Bott,Andrew R. Barron Dalton Trans., 2004, 3689-3694
• 4. An approach to C–N activation: coupling of arenesulfonyl hydrazides and arenesulfonyl chlorides with tert-amines via a metal-, oxidant- and halogen-free anodic oxidation??
  M. Sheykhan,S. Khani,S. Shaabanzadeh,M. Joafshan Green Chem., 2017,19, 5940-5948
• 5. An amphoteric reactivity of a mixed-valent bis(μ-oxo)dimanganese(iii,iv) complex acting as an electrophile and a nucleophile?
  Muniyandi Sankaralingam,So Hyun Jeon,Yong-Min Lee,Mi Sook Seo,Wonwoo Nam Dalton Trans., 2016,45, 376-383

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Phenyl-1,3-oxazoles
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Oxazoles Phenyl-1,3-oxazoles

Comprehensive Overview of 4-(chloromethyl)-2-phenyl-1,3-oxazole (CAS No. 30494-97-4)

4-(chloromethyl)-2-phenyl-1,3-oxazole, with the CAS number 30494-97-4, is a versatile heterocyclic compound that has garnered significant attention in pharmaceutical and agrochemical research. This oxazole derivative is characterized by its unique molecular structure, combining a phenyl ring and a chloromethyl group, which makes it a valuable intermediate in organic synthesis. Researchers and industries are increasingly exploring its potential applications due to its reactivity and functional versatility.

The compound's molecular formula C10H8ClNO and molecular weight 193.63 g/mol highlight its compact yet highly functionalized nature. Its oxazole core is a five-membered ring containing both nitrogen and oxygen atoms, which contributes to its stability and reactivity. The presence of the chloromethyl group (-CH2Cl) allows for further derivatization, making it a key building block in the synthesis of more complex molecules. This feature is particularly valuable in medicinal chemistry, where structure-activity relationships (SAR) are critical for drug development.

In recent years, the demand for heterocyclic compounds like 4-(chloromethyl)-2-phenyl-1,3-oxazole has surged, driven by their applications in drug discovery and material science. For instance, oxazole derivatives are frequently investigated for their antimicrobial, anti-inflammatory, and anticancer properties. The compound's ability to act as a pharmacophore or a scaffold in drug design has made it a subject of numerous scientific studies. Additionally, its role in agrochemical formulations has been explored, particularly in the development of novel pesticides and herbicides.

From a synthetic perspective, 4-(chloromethyl)-2-phenyl-1,3-oxazole can be prepared through various routes, including cyclization reactions and functional group transformations. One common method involves the reaction of 2-phenyloxazole with chloromethylating agents under controlled conditions. The choice of reagents and reaction conditions can significantly influence the yield and purity of the final product, making optimization a critical step in its production. Advanced techniques such as HPLC and NMR spectroscopy are often employed to characterize and validate the compound's structure.

The growing interest in sustainable chemistry has also impacted the synthesis and application of 4-(chloromethyl)-2-phenyl-1,3-oxazole. Researchers are increasingly focusing on green chemistry approaches to minimize environmental impact. For example, the use of catalysts and solvent-free reactions has been explored to enhance the efficiency of its synthesis. These advancements align with global trends toward eco-friendly chemical processes and reduced carbon footprints.

In the context of market trends, the compound's applications in pharmaceutical intermediates and specialty chemicals have driven its commercial demand. Companies specializing in custom synthesis and contract research often list 4-(chloromethyl)-2-phenyl-1,3-oxazole as part of their portfolio, catering to clients in the life sciences and agrochemical sectors. Its availability in various purity grades, including analytical standard and research-grade, further underscores its utility in diverse settings.

Safety and handling of 4-(chloromethyl)-2-phenyl-1,3-oxazole are also critical considerations. While the compound is not classified as hazardous under standard regulations, proper laboratory practices should be followed to ensure safe usage. This includes the use of personal protective equipment (PPE) and adherence to chemical storage guidelines. Material Safety Data Sheets (MSDS) provide detailed information on its physical and chemical properties, as well as recommended safety measures.

Looking ahead, the future of 4-(chloromethyl)-2-phenyl-1,3-oxazole appears promising, with ongoing research uncovering new applications and synthetic methodologies. Its role in high-value chemical synthesis and biologically active molecules positions it as a compound of enduring interest. As the scientific community continues to explore its potential, 4-(chloromethyl)-2-phenyl-1,3-oxazole is likely to remain a focal point in both academic and industrial research.

• 877-39-4(4-methyl-2-phenyl-1,3-oxazole)
• 22091-38-9(2-(4-Bromophenyl)-4-(chloromethyl)-1,3-oxazole)
• 22091-36-7(4-(Chloromethyl)-2-(4-chlorophenyl)-1,3-oxazole)
• 22091-40-3(4-(Chloromethyl)-2-4-(trifluoromethyl)phenyl-1,3-oxazole)
• 1038369-31-1(2-(3-bromophenyl)-4-(chloromethyl)-1,3-oxazole)
• 625826-70-2(Oxazole, 4-(chloromethyl)-2-[4-(1,1-dimethylethyl)phenyl]-)
• 202594-71-6(4-(Chloromethyl)-2-(naphthalen-2-yl)oxazole)
• 1204-70-2(2-Phenyl-1,3-oxazole-4-carbonyl Chloride)
• 22091-39-0(4-(chloromethyl)-2-(4-fluorophenyl)-1,3-oxazole)
• 625825-66-3(Oxazole, 4-(chloromethyl)-2-(2-methylphenyl)-)