Cas no 304698-96-2 (Nim-Trityl-L-histidine tert-butyl ester hydrochloride)

Nim-Trityl-L-histidine tert-butyl ester hydrochloride is a protected derivative of L-histidine, designed for peptide synthesis applications. The trityl (Trt) group at the N-imidazole position provides selective protection, preventing unwanted side reactions during solid-phase or solution-phase peptide coupling. The tert-butyl ester offers acid-labile protection for the carboxyl group, ensuring compatibility with standard Fmoc/tBu strategies. This compound is particularly advantageous in complex peptide syntheses where histidine residues require selective deprotection under mild conditions. The hydrochloride salt form enhances solubility in organic solvents, facilitating handling in peptide elongation. Its stability and orthogonal protecting groups make it a reliable choice for synthesizing histidine-containing peptides with high purity and yield.
Nim-Trityl-L-histidine tert-butyl ester hydrochloride structure
304698-96-2 structure
Product Name:Nim-Trityl-L-histidine tert-butyl ester hydrochloride
CAS No:304698-96-2
MF:C29H31N3O2
MW:453.575347185135
MDL:MFCD03093489
CID:299591
PubChem ID:11363002
Update Time:2025-06-08

Nim-Trityl-L-histidine tert-butyl ester hydrochloride Chemical and Physical Properties

Names and Identifiers

    • L-Histidine,1-(triphenylmethyl)-, 1,1-dimethylethyl ester
    • H-His(1-Trt)-OtBu
    • H-HIS(TAU-TRT)-OTBU
    • H-HIS(TRT)-OTBU
    • H-HIS(T-TRT)-OTBU
    • HISTIDINE(1-TRT)-OTBU
    • N-IM-TRITYL-L-HISTIDINE T-BUTYL ESTER
    • H-His(-Trt)-OtBu
    • BXLIDDXLXQZXMR-SANMLTNESA-N
    • MFCD03093489
    • Tert-butyl (2S)-2-amino-3-(1-tritylimidazol-4-yl)propanoate
    • tert-Butyl 1-(triphenylmethyl)-L-histidine ester
    • FD21688
    • tert-butyl (2S)-2-amino-3-[1-(triphenylmethyl)-1H-imidazol-4-yl]propanoate
    • SCHEMBL7368138
    • tert-Butyl Nt-trityl-L-histidinate
    • His(Trt)-OtBu
    • EN300-19831272
    • 304698-96-2
    • (S)-tert-Butyl 2-amino-3-(1-trityl-1H-imidazol-4-yl)propanoate
    • Nim-Trityl-L-histidine tert-butyl ester hydrochloride
    • MDL： MFCD03093489
    • Inchi： 1S/C29H31N3O2/c1-28(2,3)34-27(33)26(30)19-25-20-32(21-31-25)29(22-13-7-4-8-14-22,23-15-9-5-10-16-23)24-17-11-6-12-18-24/h4-18,20-21,26H,19,30H2,1-3H3/t26-/m0/s1
    • InChI Key： BXLIDDXLXQZXMR-SANMLTNESA-N
    • SMILES： O(C([C@H](CC1=CN(C=N1)C(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)N)=O)C(C)(C)C

Computed Properties

  • Exact Mass: 453.24162724g/mol
  • Monoisotopic Mass: 453.24162724g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 34
  • Rotatable Bond Count: 9
  • Complexity: 597
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 1
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 5.1
  • Topological Polar Surface Area: 70.1?2

Experimental Properties

  • Density: 1.10±0.1 g/cm3 (20 oC 760 Torr),
  • Solubility: Insuluble (8.2E-3 g/L) (25 oC),

Nim-Trityl-L-histidine tert-butyl ester hydrochloride Pricemore >>

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Nim-Trityl-L-histidine tert-butyl ester hydrochloride Suppliers

Amadis Chemical Company Limited
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(CAS:304698-96-2)Nim-Trityl-L-histidine tert-butyl ester hydrochloride
Order Number:A1233015
Stock Status:in Stock
Quantity:1g
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 19:37
Price ($):204

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Amadis Chemical Company Limited
(CAS:304698-96-2)Nim-Trityl-L-histidine tert-butyl ester hydrochloride
A1233015
Purity:99%
Quantity:1g
Price ($):204
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