• 1. Aggregation-induced chiroptical generation and photoinduced switching of achiral azobenzene-alt-fluorene copolymer endowed with left- and right-handed helical polysilanes?
  Hailing Chen,Lu Yin,Meng Liu,Laibing Wang,Michiya Fujiki,Wei Zhang RSC Adv., 2019,9, 4849-4856
• 2. An algal process treatment combined with the Fenton reaction for high concentrations of amoxicillin and cefradine
  Haitao Li,Yu Pan,Zhizhi Wang,Shan Chen,Ruixin Guo,Jianqiu Chen RSC Adv., 2015,5, 100775-100782
• 3. An investigation of surface properties, local elastic modulus and interaction with simulated pulmonary surfactant of surface modified inhalable voriconazole dry powders using atomic force microscopy
  Michael Kappl,Paul M. Young,Daniela Traini,Sanyog Jain RSC Adv., 2016,6, 25789-25798
• 4. Aggregation of biologically important peptides and proteins: inhibition or acceleration depending on protein and metal ion concentrations
  Benjamin Gabriel Poulson,Kacper Szczepski,Joanna Izabela Lachowicz,Lukasz Jaremko,Abdul-Hamid Emwas,Mariusz Jaremko RSC Adv., 2020,10, 215-227
• 5. An aptasensor for detection of potassium ions based on RecJf exonuclease mediated signal amplification
  Bidou Wang,Xifeng Chen Analyst, 2014,139, 5695-5699

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzenesulfonamides

Comprehensive Overview of 1-(Phenylsulfonyl)piperidine-4-carboxamide (CAS No. 304668-32-4): Properties, Applications, and Research Insights

1-(Phenylsulfonyl)piperidine-4-carboxamide (CAS No. 304668-32-4) is a specialized organic compound gaining attention in pharmaceutical and chemical research due to its unique structural features and potential applications. This piperidine derivative combines a phenylsulfonyl group with a carboxamide moiety, making it a versatile intermediate for drug discovery and material science. Its molecular formula, C₁₂H₁₆N₂O₃S, reflects a balanced hydrophobicity and polarity, which is critical for bioavailability in medicinal chemistry.

Recent studies highlight the compound's role as a key building block in synthesizing bioactive molecules, particularly in central nervous system (CNS) drug development. Researchers are exploring its potential as a scaffold for kinase inhibitors and G-protein-coupled receptor (GPCR) modulators, aligning with current trends in targeted therapy. The sulfonamide group in its structure is known to enhance binding affinity to biological targets, a feature increasingly sought after in precision medicine.

From a synthetic chemistry perspective, 304668-32-4 exemplifies modern green chemistry principles. Its preparation often involves catalytic methods with reduced solvent waste, addressing the pharmaceutical industry's focus on sustainable manufacturing. Analytical techniques like HPLC-MS and NMR spectroscopy confirm its high purity (>98%), meeting stringent standards for preclinical research. These qualities make it valuable for high-throughput screening platforms, where reproducibility is paramount.

The compound's physicochemical properties—including a melting point of 162–165°C and moderate water solubility—enable diverse formulation strategies. This adaptability responds to growing demand for drug delivery optimization, especially in blood-brain barrier penetration studies. Computational models suggest its logP value of 1.2 positions it favorably within Lipinski's rule of five, a frequent search topic among medicinal chemists evaluating drug-likeness.

Emerging applications extend beyond pharmaceuticals. Material scientists are investigating 1-(Phenylsulfonyl)piperidine-4-carboxamide as a monomer for functional polymers, capitalizing on its ability to impart thermal stability. This dual utility in life sciences and materials engineering reflects the interdisciplinary nature of contemporary chemical innovation—a subject generating substantial academic and industrial interest.

Quality control protocols for CAS No. 304668-32-4 emphasize genotoxic impurity monitoring, addressing stringent regulatory requirements. Stability studies under ICH guidelines demonstrate its robustness in various pH conditions, a critical consideration for formulation scientists. These technical aspects frequently appear in literature searches by professionals navigating Quality by Design (QbD) frameworks.

Market analyses indicate rising demand for such high-value intermediates, driven by expanding contract research organizations and generic drug development. The compound's patent landscape shows strategic importance, with several applications citing derivatives for neurodegenerative disease targets—an area receiving unprecedented research funding globally.

In conclusion, 1-(Phenylsulfonyl)piperidine-4-carboxamide represents a convergence point for multiple scientific priorities: sustainable synthesis, targeted therapeutics, and advanced materials. Its ongoing investigation underscores the compound's relevance in addressing current challenges across chemical and biological disciplines, making it a subject worthy of continued academic and industrial attention.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)