• 1. An atmosphere and light tuned highly diastereoselective synthesis of cyclobuta/penta[b]indoles from aniline-tethered alkylidenecyclopropanes with alkynes?
  Bo Cao,Yin Wei Chem. Commun., 2018,54, 2870-2873
• 2. Acetyl group orientation modulates the electronic ground-state asymmetry of the special pair in purple bacterial reaction centers
  P. K. Wawrzyniak,M. T. P. Beerepoot,H. J. M. de Groot,F. Buda Phys. Chem. Chem. Phys., 2011,13, 10270-10279
• 3. An amorphous Cu–In–S nanoparticle-based precursor ink with improved atom economy for CuInSe2 solar cells with 10.85% efficiency?
  Green Chem., 2017,19, 1268-1277
• 4. An approach to asymmetric synthesis of β-aryl alanines by Pd(0)-catalyzed cross-coupling and cyanate-to-isocyanate rearrangement?
  Piotr Szcze?niak,Sebastian Stecko RSC Adv., 2015,5, 30882-30888
• 5. An artificial CO-releasing metalloprotein built by histidine-selective metallation?
  Inês S. Albuquerque,Hélia F. Jeremias,Miguel Chaves-Ferreira,Dijana Matak-Vinkovic,Omar Boutureira,Carlos C. Rom?o Chem. Commun., 2015,51, 3993-3996

Comprehensive Overview of 2-(Aminomethyl)-4-Thiazolecarbonitrile (CAS No. 302341-70-4)

2-(Aminomethyl)-4-Thiazolecarbonitrile (CAS No. 302341-70-4) is a specialized organic compound that has garnered significant attention in pharmaceutical and agrochemical research. This heterocyclic compound features a thiazole ring, a cyanogroup, and an aminomethyl substituent, making it a versatile intermediate for synthesizing bioactive molecules. Its unique structure contributes to its applications in drug discovery, particularly in the development of kinase inhibitors and antimicrobial agents.

In recent years, the demand for thiazole derivatives like 2-(Aminomethyl)-4-Thiazolecarbonitrile has surged due to their role in addressing global health challenges. Researchers are exploring its potential in combating antibiotic-resistant bacteria, a pressing issue highlighted by the WHO. Additionally, its relevance in cancer therapeutics aligns with the growing focus on targeted therapy, a hot topic in oncology. The compound’s structure-activity relationship (SAR) is frequently studied to optimize its efficacy in small-molecule drug design.

The synthesis of 2-(Aminomethyl)-4-Thiazolecarbonitrile typically involves multistep organic reactions, including cyclization and functional group modification. Advanced techniques such as microwave-assisted synthesis and flow chemistry are increasingly employed to enhance yield and purity, addressing the industry’s shift toward green chemistry. These methods reduce waste and energy consumption, resonating with the sustainable chemistry movement.

From a commercial perspective, 302341-70-4 is supplied by leading fine chemical manufacturers under stringent GMP compliance. Its storage and handling require attention to moisture sensitivity, a common query among laboratory professionals. Analytical characterization via HPLC, NMR, and mass spectrometry ensures batch consistency, a critical factor for quality control in preclinical studies.

Frequently asked questions about 2-(Aminomethyl)-4-Thiazolecarbonitrile include its solubility profile (e.g., in DMSO or ethanol) and stability under acidic conditions. These properties are vital for formulation scientists working on drug delivery systems. Moreover, its patent landscape reflects its utility in proprietary pharmaceutical compositions, a trending subject in intellectual property discussions.

In conclusion, CAS No. 302341-70-4 represents a pivotal building block in modern medicinal chemistry. Its integration into high-throughput screening libraries and combinatorial chemistry underscores its value in accelerating drug discovery pipelines. As research progresses, this compound is poised to play a central role in addressing unmet medical needs while adhering to environmental, social, and governance (ESG) principles in chemical production.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)