Cas no 298690-75-2 (2-(3,4-difluorophenyl)pyrrolidine)

2-(3,4-Difluorophenyl)pyrrolidine is a fluorinated pyrrolidine derivative with potential applications in pharmaceutical and agrochemical research. The presence of difluorophenyl and pyrrolidine moieties enhances its utility as a versatile intermediate in medicinal chemistry, particularly in the development of bioactive molecules. The fluorine substituents improve metabolic stability and binding affinity, making it valuable for structure-activity relationship (SAR) studies. Its rigid pyrrolidine scaffold contributes to conformational restriction, aiding in the design of selective ligands. The compound’s synthetic flexibility allows for further functionalization, enabling tailored modifications for target-specific applications. Suitable for controlled environments, it should be handled with standard safety precautions for fluorinated organic compounds.
2-(3,4-difluorophenyl)pyrrolidine structure
298690-75-2 structure
Product Name:2-(3,4-difluorophenyl)pyrrolidine
CAS No:298690-75-2
MF:C10H11F2N
MW:183.1978495121
MDL:MFCD06740445
CID:239125
PubChem ID:21706777
Update Time:2025-06-08

2-(3,4-difluorophenyl)pyrrolidine Chemical and Physical Properties

Names and Identifiers

    • Pyrrolidine,2-(3,4-difluorophenyl)-
    • 2-(3,4-difluorophenyl)pyrrolidine
    • 2-(3,4-DIFLUORO-PHENYL)-PYRROLIDINE
    • A26447
    • AB1006605
    • AB29073
    • AG-A-29209
    • CTK7C1235
    • SureCN3330878
    • DTXSID20617179
    • AKOS000160362
    • FT-0728275
    • SCHEMBL3330878
    • D83323
    • AS-62324
    • SZPJRABUCTXGIN-UHFFFAOYSA-N
    • EN300-146014
    • CS-0155427
    • MFCD06740445
    • 298690-75-2
    • AKOS022300831
    • (RS)-2-(3,4-difluoro-phenyl)-pyrrolidine
    • DB-068169
    • SY253312
    • MDL： MFCD06740445
    • Inchi： 1S/C10H11F2N/c11-8-4-3-7(6-9(8)12)10-2-1-5-13-10/h3-4,6,10,13H,1-2,5H2
    • InChI Key： SZPJRABUCTXGIN-UHFFFAOYSA-N
    • SMILES： FC1=C(C=CC(=C1)C1CCCN1)F

Computed Properties

  • Exact Mass: 183.08600
  • Monoisotopic Mass: 183.086
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 1
  • Heavy Atom Count: 13
  • Rotatable Bond Count: 1
  • Complexity: 174
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 1
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 12A^2
  • XLogP3: 2

Experimental Properties

  • Density: 1.164
  • Boiling Point: 232 oC
  • Flash Point: 94 oC
  • PSA: 12.03000
  • LogP: 2.71810

2-(3,4-difluorophenyl)pyrrolidine Customs Data

  • HS CODE：2933990090
  • Customs Data：

    China Customs Code:

    2933990090

    Overview:

    2933990090. Other heterocyclic compounds containing only nitrogen heteroatoms. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2-(3,4-difluorophenyl)pyrrolidine Pricemore >>

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2-(3,4-difluorophenyl)pyrrolidine Related Literature

Additional information on 2-(3,4-difluorophenyl)pyrrolidine

Recent Advances in the Study of 2-(3,4-Difluorophenyl)pyrrolidine (CAS: 298690-75-2) in Chemical Biology and Pharmaceutical Research

The compound 2-(3,4-difluorophenyl)pyrrolidine (CAS: 298690-75-2) has recently garnered significant attention in the field of chemical biology and pharmaceutical research due to its potential therapeutic applications. This molecule, characterized by its pyrrolidine core and difluorophenyl substituent, has been explored for its role in modulating various biological targets. Recent studies have focused on its synthesis, pharmacological properties, and potential as a lead compound in drug discovery.

One of the key areas of interest is the compound's interaction with neurotransmitter receptors. Preliminary research indicates that 2-(3,4-difluorophenyl)pyrrolidine exhibits affinity for serotonin and dopamine receptors, suggesting its potential utility in treating neurological disorders such as depression and Parkinson's disease. In vitro studies have demonstrated its ability to modulate receptor activity, though further in vivo validation is required to confirm these findings.

Another significant development is the optimization of synthetic routes for 2-(3,4-difluorophenyl)pyrrolidine. Recent publications have highlighted novel catalytic methods that improve yield and purity, making the compound more accessible for large-scale pharmaceutical applications. These advancements are critical for ensuring the compound's viability in preclinical and clinical studies.

In addition to its neurological applications, 2-(3,4-difluorophenyl)pyrrolidine has shown promise in oncology research. Early-stage studies suggest that the compound may inhibit specific kinases involved in cancer cell proliferation. While these findings are preliminary, they open new avenues for the development of targeted cancer therapies.

Despite these promising results, challenges remain. The pharmacokinetic properties of 2-(3,4-difluorophenyl)pyrrolidine, such as its metabolic stability and bioavailability, require further investigation. Additionally, comprehensive toxicology studies are needed to assess its safety profile before advancing to clinical trials.

In conclusion, 2-(3,4-difluorophenyl)pyrrolidine (CAS: 298690-75-2) represents a versatile and promising compound in chemical biology and pharmaceutical research. Its potential applications in neurology and oncology, coupled with recent synthetic advancements, underscore its value as a subject of ongoing study. Future research should focus on addressing the remaining challenges to fully realize its therapeutic potential.

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