• 1. Design and synthesis of a chemosensor for the detection of Al3+ based on ESIPT
  Jing-can Qin,Zheng-yin Yang,Long Fan,Xiao-ying Cheng,Tian-rong Li,Bao-dui Wang Anal. Methods 2014 6 7343

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Quinolines and derivatives Quinoline carboxamides

2-Methylquinoline-4-carbohydrazide: A Comprehensive Overview

2-Methylquinoline-4-carbohydrazide, identified by the CAS registry number 29620-66-4, is a heterocyclic compound with significant potential in various fields of chemistry and materials science. This compound belongs to the class of quinolines, which are aromatic six-membered rings fused with a nitrogen-containing five-membered ring. The presence of a methyl group at the 2-position and a carbohydrazide group at the 4-position imparts unique chemical properties, making it a subject of interest for researchers and industry professionals alike.

The structure of 2-Methylquinoline-4-carbohydrazide is characterized by its rigid aromatic framework and functional groups that enable diverse reactivity. The quinoline core is known for its stability and ability to participate in various chemical reactions, including electrophilic substitution, nucleophilic aromatic substitution, and cycloaddition reactions. The carbohydrazide group, on the other hand, introduces nucleophilic character and can act as a precursor for the formation of hydrazones or other nitrogen-containing derivatives. This combination of functionalities makes 2-Methylquinoline-4-carbohydrazide a versatile building block in organic synthesis.

Recent studies have highlighted the potential of 2-Methylquinoline-4-carbohydrazide in drug discovery and materials science. In the field of pharmacology, researchers have explored its role as a scaffold for developing bioactive molecules with anti-inflammatory, anticancer, and antimicrobial properties. For instance, derivatives of this compound have shown promising results in inhibiting key enzymes associated with inflammatory pathways, such as cyclooxygenase (COX) and lipoxygenase (LOX). These findings suggest that 2-Methylquinoline-4-carbohydrazide-based compounds could serve as leads for developing novel therapeutic agents.

In materials science, the compound has been investigated for its potential as a precursor in the synthesis of advanced materials, such as coordination polymers and metal-organic frameworks (MOFs). The nitrogen atoms in the quinoline ring and the carbohydrazide group can act as coordinating sites, enabling the formation of stable metal-ligand bonds. This property makes 2-Methylquinoline-4-carbohydrazide a valuable component in designing MOFs with applications in gas storage, catalysis, and sensing technologies.

The synthesis of 2-Methylquinoline-4-carbohydrazide typically involves multi-step processes that combine traditional organic synthesis techniques with modern catalytic methods. One common approach involves the condensation of 2-methylquinolinone with hydrazine derivatives under controlled conditions. Researchers have also explored green chemistry methods to enhance the efficiency and sustainability of these reactions. For example, microwave-assisted synthesis has been reported to significantly reduce reaction times while maintaining high yields.

The application of computational chemistry tools has further expanded our understanding of the properties of 2-Methylquinoline-4-carbohydrazide. Density functional theory (DFT) calculations have been used to study its electronic structure, reactivity, and interaction with biological targets. These insights have guided the design of more potent derivatives and optimized synthetic pathways.

In conclusion, 2-Methylquinoline-4-carbohydrazide, CAS No. 29620-66-4, is a multifaceted compound with wide-ranging applications across various scientific disciplines. Its unique chemical structure, combined with recent advancements in synthetic methods and computational modeling, positions it as a key player in future research and development efforts. As ongoing studies continue to uncover new potentials for this compound, it is poised to make significant contributions to both academic research and industrial applications.

• 78224-52-9(2-Quinolinecarboxylicacid, 7-methyl-, hydrazide)
• 3758-59-6(2-Methylisonicotinohydrazide)
• 4779-54-8(2-Phenylquinoline-4-carbohydrazide)
• 427891-96-1(6-Quinolinecarboxylicacid, 2-methyl-, hydrazide)
• 5206-34-8(2-(Pyridin-4-yl)quinoline-4-carbohydrazide)
• 36705-76-7(9-Acridinecarboxylicacid, hydrazide)
• 29620-62-0(Quinoline-4-carbohydrazide)
• 15821-13-3(2-Methylquinoline-4-carboxamide)
• 5094-42-8(1H-Indole-5-carboxylicacid, 2,3-dimethyl-, hydrazide)
• 5109-96-6(2-(Pyridin-2-yl)quinoline-4-carbohydrazide)