• 1. An amorphous carbon nitride/NiO/CoN-based composite: a highly efficient nonprecious electrode for supercapacitors and the oxygen evolution reaction?
  Huifang Yang,Haoran Guo,Peidong Fan,Xinpan Li,Wenlu Ren,Rui Song Nanoscale, 2020,12, 7024-7034
• 2. An aptamer-based keypad lock system?
  Yaqing Liu,Jiangtao Ren,Jing Li,Jiyang Liu,Erkang Wang Chem. Commun., 2012,48, 802-804
• 3. An insight into the origin of room-temperature ferromagnetism in SnO2 and Mn-doped SnO2 quantum dots: an experimental and DFT approach?
  Dhamodaran Manikandan,S. Amirthapandian,I. S. Zhidkov,A. I. Kukharenko,S. O. Cholakh,Ramaswamy Murugan Phys. Chem. Chem. Phys., 2018,20, 6500-6514
• 4. An autonomous self-optimizing flow machine for the synthesis of pyridine–oxazoline (PyOX) ligands?
  Eric Wimmer,Daniel Cortés-Borda,Solène Brochard,Elvina Barré,Charlotte Truchet,Fran?ois-Xavier Felpin React. Chem. Eng., 2019,4, 1608-1615
• 5. An integrated chip for immunofluorescence and its application to analyze lysosomal storage disorders
  Jie Shen,Ying Zhou,Tu Lu,Junya Peng,Zhixiang Lin,Yuhong Pang,Li Yu Lab Chip, 2012,12, 317-324

• Solvents and Organic Chemicals Organic Compounds Benzenoids Indanes Indanones

6-Fluoro-5-methoxy-2,3-dihydro-1H-inden-1-one: A Comprehensive Overview

6-Fluoro-5-methoxy-2,3-dihydro-1H-inden-1-one, also known by its CAS number 295779-82-7, is a compound of significant interest in the fields of organic chemistry and pharmacology. This compound belongs to the class of indenone derivatives, which have been extensively studied for their diverse biological activities. The structure of 6-fluoro-5-methoxy-indenone features a fused bicyclic system with a ketone group at position 1, a methoxy group at position 5, and a fluoro substituent at position 6. These functional groups contribute to its unique chemical properties and potential applications in drug discovery.

The synthesis of 6-fluoro-5-methoxy-indenone has been explored through various routes, including oxidative cyclization and cross-coupling reactions. Recent advancements in catalytic methods have enabled more efficient and selective syntheses, making this compound more accessible for further research. For instance, the use of palladium-catalyzed coupling reactions has been reported to facilitate the construction of the indenone skeleton with high yields and excellent stereocontrol. These developments highlight the importance of CAS 295779-82-7 as a versatile building block in organic synthesis.

In terms of biological activity, 6-fluoro-5-methoxy-indenone has shown promising results in preliminary studies. It exhibits potent antioxidant properties, which are attributed to its ability to scavenge free radicals and inhibit oxidative stress. Additionally, this compound has demonstrated moderate anti-inflammatory activity in vitro, suggesting its potential as a lead molecule for anti-inflammatory drug development. Recent research has also explored its effects on cellular signaling pathways, particularly the MAPK and NF-kB pathways, which are implicated in various inflammatory diseases.

The pharmacokinetic profile of CAS 295779-82-7 has been investigated in preclinical models, revealing favorable absorption and bioavailability. These findings underscore its suitability for further exploration as a therapeutic agent. Moreover, computational studies have predicted that this compound may exhibit selective binding to certain protein targets, such as kinases and receptors, which could be exploited for targeted drug delivery.

In conclusion, 6-fluoro-5-methoxy-indenone (CAS 295779-82-7) represents a valuable compound with diverse applications in organic chemistry and pharmacology. Its unique structure, coupled with its promising biological activities and favorable pharmacokinetic properties, positions it as a compelling candidate for further research and development in the field of drug discovery.

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• 295779-88-3(8-Fluoro-7-methoxy-3,4-dihydronaphthalen-1(2H)-one)
• 63185-71-7(1,3-Propanedione, 1-(4-fluoro-3-methoxyphenyl)-3-phenyl-)
• 1092347-75-5(5,8-Difluoro-7-methoxy-3,4-dihydronaphthalen-1(2H)-one)
• 63185-70-6(1,3-Hexanedione, 1-(4-fluoro-3-methoxyphenyl)-)
• 63185-67-1(1,3-Butanedione, 1-(4-fluoro-3-methoxyphenyl)-)
• 917885-01-9(5-Fluoro-6-hydroxy-2,3-dihydro-1H-inden-1-one)
• 586-20-9(3Fluoro-4methoxyvalerophenone)
• 63185-69-3(1,3-Pentanedione, 1-(4-fluoro-3-methoxyphenyl)-)
• 83802-71-5(5-Fluoro-6-methoxy-2,3-dihydro-1H-inden-1-one)