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• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Steroids and steroid derivatives Ergosterols and derivatives
• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Steroids and steroid derivatives Ergostane steroids Ergosterols and derivatives

24(28)-Dehydroergosterol (CAS No. 29560-24-5): A Comprehensive Overview

24(28)-Dehydroergosterol, also known by its CAS number 29560-24-5, is a sterol compound that has garnered significant attention in the fields of chemistry, biochemistry, and pharmacology. This compound is a derivative of ergosterol, a key sterol found in the cell membranes of fungi and some plants. The unique structural features and biological activities of 24(28)-Dehydroergosterol make it a valuable subject of research, particularly in the context of its potential applications in pharmaceuticals and biotechnology.

The chemical structure of 24(28)-Dehydroergosterol is characterized by the presence of a double bond at the 24(28) position, which differentiates it from ergosterol. This structural modification imparts distinct properties to the compound, including enhanced stability and altered biological activity. The molecular formula of 24(28)-Dehydroergosterol is C₂₈H₄₄O, and its molecular weight is approximately 396.67 g/mol.

In recent years, the study of 24(28)-Dehydroergosterol has been driven by its potential therapeutic applications. One of the most promising areas of research is its role in modulating cholesterol metabolism. Studies have shown that 24(28)-Dehydroergosterol can influence cholesterol synthesis and absorption, making it a potential candidate for the development of cholesterol-lowering drugs. For instance, a study published in the Journal of Lipid Research demonstrated that 24(28)-Dehydroergosterol can inhibit HMG-CoA reductase, a key enzyme in cholesterol biosynthesis, thereby reducing cholesterol levels in vitro and in vivo.

Beyond its effects on cholesterol metabolism, 24(28)-Dehydroergosterol has also been investigated for its potential anti-inflammatory properties. Inflammatory diseases such as arthritis and inflammatory bowel disease (IBD) are major health concerns worldwide, and there is a growing need for effective treatments. Research has indicated that 24(28)-Dehydroergosterol can exert anti-inflammatory effects by modulating the expression of pro-inflammatory cytokines and enzymes. A study published in the Journal of Inflammation Research found that 24(28)-Dehydroergosterol significantly reduced the production of TNF-α and IL-6 in lipopolysaccharide (LPS)-stimulated macrophages.

The antioxidant properties of 24(28)-Dehydroergosterol have also been explored. Oxidative stress is a contributing factor to various diseases, including cardiovascular disease, neurodegenerative disorders, and cancer. Studies have shown that 24(28)-Dehydroergosterol can scavenge free radicals and protect cells from oxidative damage. A study published in the Journal of Agricultural and Food Chemistry demonstrated that 24(28)-Dehydroergosterol exhibited strong antioxidant activity in both cell-free systems and cellular models.

In addition to its therapeutic potential, 24(28)-Dehydroergosterol has been studied for its role in fungal biology. Ergosterol is essential for fungal cell membrane integrity, and compounds that interfere with ergosterol biosynthesis are often used as antifungal agents. Research has shown that 24(28)-Dehydroergosterol can disrupt fungal cell membranes by altering ergosterol levels, making it a potential lead compound for the development of new antifungal drugs. A study published in the Journal of Antimicrobial Chemotherapy found that 24(28)-Dehydroergosterol exhibited potent antifungal activity against several clinically relevant fungal pathogens.

The synthesis and purification of 24(28)-Dehydroergosterol have been optimized to meet the demands of both research and industrial applications. Various methods have been developed to synthesize this compound from natural sources or through chemical synthesis. One common approach involves the oxidation of ergosterol using mild oxidizing agents such as potassium permanganate or osmium tetroxide. These methods have been refined to achieve high yields and purity levels, ensuring that the compound meets the stringent quality standards required for pharmaceutical use.

The safety profile of 24(28)-Dehydroergosterol

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• 67-97-0(Vitamin D3)
• 10346-44-8(Cholesta-5,7-dien-3-ol,(3b,9b)- (9CI))
• 434-16-2((3b)-7-Dehydro Cholesterol)
• 10346-43-7(Cholesta-5,7-dien-3-ol,(3b,10a)- (9CI))
• 50-14-6(Vitamin D2)
• 57-87-4(Ergosterol Standard)
• 128-27-8(Ergosta-5,7,22-trien-3-ol,(3b,10a,22E)- (9CI))
• 1715-86-2(7-Dehydro Desmosterol)
• 19633-95-5(Cholesta-5,7,22-trien-3-ol,(3b)-)
• 1406-16-2(Vitamin D)