• 1. Establishing the accuracy of position-specific carbon isotope analysis of propane by GC-pyrolysis-GC-IRMS
  ChangjieLiu,PengLiu,XiaofengWang,XiaoqiangLi,JuskeHorita
• 2. Estimates of hydride ion stability in condensed systems: energy of formation and solvation in aqueous and polar-organic solvents
  Craig A. Kelly,David R. Rosseinsky Phys. Chem. Chem. Phys., 2001,3, 2086-2090
• 3. EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis?
  Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739
• 4. Fe3O4 nanoclusters highly dispersed on a porous graphene support as an additive for improving the hydrogen storage properties of LiBH4?
  Guang Xu,Wei Zhang,Ying Zhang,Xiaoxia Zhao,Ping Wen,Di Ma RSC Adv., 2018,8, 19353-19361
• 5. Dissociation of aryl sulfonyl phthalimide radical anions: relevance to the biological activity of arylsulfonyl amides?
  Abdelaziz Houmam,Emad M. Hamed Chem. Commun., 2012,48, 11328-11330

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzothiazoles Benzothiazoles
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzothiazoles

Comprehensive Overview of 2-Chloro-7-nitrobenzo[d]thiazole (CAS No. 2942-22-5): Properties, Applications, and Research Insights

2-Chloro-7-nitrobenzo[d]thiazole (CAS No. 2942-22-5) is a heterocyclic organic compound that has garnered significant attention in pharmaceutical and materials science research. This nitro-substituted benzothiazole derivative is characterized by its unique molecular structure, combining a chloro group at the 2-position and a nitro group at the 7-position. Such structural features make it a versatile intermediate in synthetic chemistry, particularly in the development of bioactive molecules and functional materials.

In recent years, the demand for 2-Chloro-7-nitrobenzo[d]thiazole has surged due to its potential applications in drug discovery and agrochemical formulations. Researchers are particularly interested in its role as a precursor for antimicrobial agents and fluorescence probes, aligning with the growing focus on antibiotic resistance and diagnostic imaging technologies. The compound's electron-withdrawing nitro group enhances its reactivity in nucleophilic substitution reactions, making it valuable for constructing complex molecular architectures.

From a physicochemical perspective, 2-Chloro-7-nitrobenzo[d]thiazole typically appears as a yellow crystalline solid with moderate solubility in organic solvents like dichloromethane and dimethyl sulfoxide (DMSO). Its stability under ambient conditions facilitates handling in laboratory settings, though precautions are recommended to avoid prolonged exposure to light or moisture. Analytical techniques such as HPLC, NMR spectroscopy, and mass spectrometry are commonly employed to verify its purity and structural integrity.

The compound's relevance extends to material science, where its conjugated π-system contributes to applications in organic electronics and photocatalysts. With the rise of green chemistry initiatives, researchers are exploring eco-friendly synthetic routes to produce 2-Chloro-7-nitrobenzo[d]thiazole with minimal waste generation. This aligns with broader industry trends toward sustainable chemical manufacturing.

Frequently asked questions about CAS No. 2942-22-5 include inquiries about its synthetic protocols, safety data sheets (SDS), and commercial availability. Suppliers often highlight its use in high-throughput screening libraries for kinase inhibitors, reflecting its importance in precision medicine research. Additionally, its structure-activity relationships (SAR) are a hot topic in medicinal chemistry forums, particularly for designing anti-inflammatory compounds.

In conclusion, 2-Chloro-7-nitrobenzo[d]thiazole represents a critical building block in modern chemical research. Its dual functionality as a pharmaceutical intermediate and material precursor underscores its multidisciplinary appeal. As scientific communities prioritize molecular diversity and functional innovation, this compound is poised to remain at the forefront of cutting-edge applications.

• 70200-91-8(2,4-Dichloro-7-nitro-1,3-benzothiazole)
• 145915-48-6(Benzothiazole, 2,4,6-trichloro-7-nitro-)
• 3622-38-6(2-chloro-5-nitro-1,3-benzothiazole)
• 2407-11-6(2-chloro-6-nitro-1,3-benzothiazole)
• 144631-85-6(6-Benzothiazolamine, 2-chloro-7-nitro-)
• 3507-30-0(2-Chloro-4-nitrobenzo[d]thiazole)
• 2942-07-6(5-nitro-1,3-benzothiazole)
• 30132-81-1(benzothiazole, 6-chloro-7-nitro- (8ci))
• 7673-95-2( )
• 2942-05-4(7-Nitrobenzo[d]thiazole)