Cas no 29400-42-8 (Helvolic Acid)
Helvolic Acid is a secondary metabolite belonging to the class of sesquiterpenoid antibiotics, primarily produced by certain fungal species such as Aspergillus and Penicillium. It exhibits notable antimicrobial properties, particularly against Gram-positive bacteria, making it a compound of interest in pharmaceutical and microbiological research. Its mechanism of action involves disrupting bacterial cell membrane integrity, leading to cell lysis. Helvolic Acid also demonstrates anti-inflammatory and potential anticancer activities, broadening its biomedical applications. The compound's unique tricyclic structure contributes to its stability and bioactivity. Due to its selective efficacy and natural origin, Helvolic Acid is a valuable candidate for further studies in drug development and antimicrobial therapies.
Helvolic Acid structure
Product Name:Helvolic Acid
CAS No:29400-42-8
MF:C33H44O8
MW:568.697670936584
CID:255782
PubChem ID:3002143
Update Time:2025-06-08
Helvolic Acid Chemical and Physical Properties
Names and Identifiers
-
- 29-Nordammara-1,17(20),24-trien-21-oicacid, 6,16-bis(acetyloxy)-3,7-dioxo-, (4a,6b,8a,9b,13a,14b,16b,17Z)-
- 29-Nordammara-1,17(20),24-trien-21-oicacid, 6,16-bis(acetyloxy)-3,7-dioxo-, (4a,6b,8a,9b,13a,1...
- HELVOLIC ACID
- 16-(Acetyloxy)-3,7-dioxo-29-nordammara-1,17(20),24-trien-21-oic acid
- 29-Nordammara-1,17(20),24-trien-21-oic acid, 6,16-bis(acetyloxy)-3,7-dioxo-, (4-alpha,6-beta,8-alpha,9-beta,13-alpha,14-beta,16-beta,17-beta)-
- BRN 3230584
- Fumigacin
- NSC 319943
- (17Z)-6beta,16beta-diacetoxy-4alpha,8,14-trimethyl-3,7-dioxo-5alpha,8alpha,9beta,13alpha,14beta-18-norcholesta-1,17,24-trien-21-oic acid
- ACon0_000265
- NCGC00169132-02
- CS-0086553
- HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS
- NS00097267
- NSC-319943
- (2Z)-2-[(4S,5S,6S,8S,9S,10R,13R,14S,16S)-6,16-diacetyloxy-4,8,10,14-tetramethyl-3,7-dioxo-5,6,9,11,12,13,15,16-octahydro-4H-cyclopenta[a]phenanthren-17-ylidene]-6-methylhept-5-enoic acid
- (4alpha,6beta,8alpha,9beta,13alpha,14beta,16beta,17beta)-6,16- bis(acetyloxy)-3,7-dioxo-29-nordammara-1,17(20),24-trien-21-oic acid
- NCGC00169132-02_C33H44O8_(4alpha,5alpha,6beta,8alpha,9beta,13alpha,14beta,16beta,17Z)-6,16-Diacetoxy-4,8,14-trimethyl-3,7-dioxo-18-norcholesta-1,17,24-trien-21-oic acid
- BRD-K08133434-001-01-0
- CHEMBL505132
- LMPR0106080005
- HY-N6728
- MEGxm0_000011
- AKOS030530131
- NCGC00169132-01
- UNII-MZX54GS8AH
- HELVOLIC ACID [MI]
- ACon1_000380
- (2Z)-2-[(4S, 5S, 6S, 8S, 9S, 10R, 13R, 14S, 16S)-6, 16-diacetyloxy-4, 8, 10, 14-tetramethyl-3, 7-dioxo-5, 6, 9, 11, 12, 13, 15, 16-octahydro-4H-cyclopenta[a]phenanthren-17-ylidene]-6-methylhept-5-enoic acid
- Q27131924
- 29400-42-8
- 3-10-00-04777 (Beilstein Handbook Reference)
- (2Z)-2-[(4alpha,5alpha,6beta,8alpha,9beta,13alpha,14beta,16beta,17Z)-6,16-diacetoxy-4,8,10,14-tetramethyl-3,7-dioxogon-1-en-17-ylidene]-6-methylhept-5-enoic acid
- (Z)-6.BETA.,16.BETA.-DIHYDROXY-3,7-DIOXO-29-NOR-8.ALPHA.,9.BETA.,13.ALPHA.,14.BETA.-DAMMARA-1,17(20),24-TRIEN-21-OIC ACID DIACETATE
- (2Z)-2-(6,16-diacetyloxy-4,8,10,14-tetramethyl-3,7-dioxo-5,6,9,11,12,13,15,16-octahydro-4H-cyclopenta[a]phenanthren-17-ylidene)-6-methylhept-5-enoic acid
- J-017496
- BH162732
- DTXSID201017874
- GTPL12329
- 29-Nordammara-1,17(20),24-trien-21-oic acid, 6,16-bis(acetyloxy)-3,7-dioxo-, (4.alpha.,6.beta.,8.alpha.,9.beta.,13.alpha.,14.beta.,16.beta.,17Z)-
- MZX54GS8AH
- CHEBI:62460
- DA-53932
- NCGC00169132-03
- Helvolic Acid
-
- Inchi： 1S/C33H44O8/c1-17(2)10-9-11-21(30(38)39)26-22-12-13-25-31(6)15-14-23(36)18(3)27(31)28(41-20(5)35)29(37)33(25,8)32(22,7)16-24(26)40-19(4)34/h10,14-15,18,22,24-25,27-28H,9,11-13,16H2,1-8H3,(H,38,39)/b26-21-/t18-,22+,24+,25+,27-,28+,31-,32+,33-/m1/s1
- InChI Key： MDFZYGLOIJNNRM-OAJDADRGSA-N
- SMILES： O(C(C)=O)[C@@H]1C([C@@]2(C)[C@@H](CC[C@H]3/C(=C(/C(=O)O)\CC/C=C(\C)/C)/[C@H](C[C@]23C)OC(C)=O)[C@]2(C=CC([C@@H](C)[C@@H]21)=O)C)=O
Computed Properties
- Exact Mass: 568.304
- Monoisotopic Mass: 568.304
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 8
- Heavy Atom Count: 41
- Rotatable Bond Count: 8
- Complexity: 1270
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 9
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 1
- XLogP3: 5.1
- Topological Polar Surface Area: 124?2
Experimental Properties
- Density: 1.1062 (rough estimate)
- Melting Point: 215°
- Boiling Point: 552.56°C (rough estimate)
- Flash Point: 209°C
- Refractive Index: 1.4900 (estimate)
- PSA: 124.04000
- LogP: 5.40010
- Specific Rotation: D25 -121° (chloroform)
Helvolic Acid Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | H274834-1mg |
Helvolic Acid |
29400-42-8 | ≥96% | 1mg |
￥773.90 | 2023-09-02 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | H274834-5mg |
Helvolic Acid |
29400-42-8 | ≥96% | 5mg |
￥2781.90 | 2023-09-02 | |
| TRC | H235125-5mg |
Helvolic Acid |
29400-42-8 | 5mg |
$586.00 | 2023-05-18 | ||
| TRC | H235125-10mg |
Helvolic Acid |
29400-42-8 | 10mg |
$1028.00 | 2023-05-18 | ||
| TRC | H235125-25mg |
Helvolic Acid |
29400-42-8 | 25mg |
$2245.00 | 2023-05-18 | ||
| TRC | H235125-50mg |
Helvolic Acid |
29400-42-8 | 50mg |
$3841.00 | 2023-05-18 | ||
| Apollo Scientific | BIBR1050-1mg |
Helvolic acid |
29400-42-8 | 1mg |
￡100.00 | 2025-02-19 | ||
| Apollo Scientific | BIBR1050-5mg |
Helvolic acid |
29400-42-8 | 5mg |
￡385.00 | 2025-02-19 | ||
| WU HAN AN JIE KAI Biomedical Technology Co., Ltd. | ajci71864-1mg |
Helvolic Acid |
29400-42-8 | 98% | 1mg |
￥831.00 | 2022-04-26 | |
| WU HAN AN JIE KAI Biomedical Technology Co., Ltd. | ajci71864-5mg |
Helvolic Acid |
29400-42-8 | 98% | 5mg |
￥2435.00 | 2022-04-26 |
Helvolic Acid Related Literature
-
Dan Yang,Yanping Zhou,Xianhong Rui,Jixin Zhu,Ziyang Lu,Eileen Fong,Qingyu Yan RSC Adv., 2013,3, 14960-14962
-
Huading Zhang,Lee R. Moore,Maciej Zborowski,P. Stephen Williams,Shlomo Margel,Jeffrey J. Chalmers Analyst, 2005,130, 514-527
-
Byungho Lim,Jaewon Jin,Jin Yoo,Seung Yong Han,Kyeongyeol Kim,Sungah Kang,Nojin Park,Sang Moon Lee,Hae Jin Kim,Seung Uk Son Chem. Commun., 2014,50, 7723-7726
-
Alexandre Vimont,Arnaud Travert,Philippe Bazin,Jean-Claude Lavalley,Marco Daturi,Christian Serre,Gérard Férey,Sandrine Bourrelly,Philip L. Llewellyn Chem. Commun., 2007, 3291-3293
-
Amit Kumar Majhi,Subbarao Kanchi,V. Venkataraman,K. G. Ayappa,Prabal K. Maiti Soft Matter, 2015,11, 8632-8640
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